Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Funded PhD: Dr. Sudipto Das - Epigenetics and Inflammatory bowel disease

This PhD project will focus on the DNA Methylation Signatures for Personalising Ulcerative Colitis Treatment

Project description

Despite on-going efforts approximately 40% of patients with chronic inflammatory bowel disease - Ulcerative Colitis (UC) fail to respond to standard-of-care biologic treatment. This thereby presents a significant unmet clinical need that requires to be addressed. The DETECT program is a distinct and innovative consortium of experts from clinical, academic and industrial sectors. Within DETECT, using novel genome-wide next generation sequencing approaches to map the epigenome of inflamed tissue, coupled with leading-edge systems modeling we aim to identify DNA methylation biomarker signatures to predict response to biologic treatment in UC and examine the potential for DNA methyltransferase inhibitors as a new approach to UC therapy. 

This research program provides a unique training environment to the PhD candidate by providing excellent training in state-of-art skill sets encompassing both wet-lab and bioinformatic approaches, through interaction with the various academic, industrial collaborators and clinical partners. In addition, the student will be encouraged to participate in the various outreach activities organized within the programme as well as present his/her work at both national and international meetings. For Dr. Das' publications, please click here

  • Research theme: Epigenetics, Inflammatory bowel disease
  • Department: Molecular and Cellular Therapeutics
  • Tenure: Four years
  • Salary: €18,500 per year 


The successful candidate should be able to demonstrate the following: 


  • An Honours Bachelor degree (grade 2.1 or above) in Biological sciences/molecular biology/genetics or Bioinformatics
  • Prior experience in a research laboratory with skills in basic molecular and histology techniques
  • Good communication skills
  • Strong organisational and administrative skills
  • Ability to work on one’s own initiative as well as in a multidisciplinary, team environment
  • Willingness to undertake training and career development
  • English language requirements for candidates who do not speak English as their first language: an IELTS score of 6.5 or above 
  • Prior experience on both bioinformatic analysis of next-generation sequencing data will be advantageous

Application process

Please apply with an up-to-date CV, a 500-word statement outlining your interest in and suitability for the position and contact details of two referees to Dr Das (

  • Application deadline: Friday, 15 March 2019 at 5pm.
  • Interview date: end of March 2019
  • Start date: early April 2019

Mentors Dr. Sudipto Das