Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

New class of near-infrared (NIR) fluorochrome for real-time fluorescence guided surgery

Donal O'Shea, Pharmaceutical & Medicinal Chemistry. Keywords: pharmacy, pharmaceutical sciences & chemistry, nir fluorochrome, fluorochrome imaging, cancer.

The use of real-time fluorescence imaging has potential in oncology as a guide for surgical resections. As over 50% of all non-skin cancers are first treated with surgery, the benefits of improved surgical outcomes are obvious. The use of longer wavelength NIR fluorochromes circumvents problems of background absorbance and auto-fluorescence from endogenous chromophores, allowing for better resolution, greater penetration of biological tissue and a reduction of light induced cellular damage. We have recently described the synthesis of a series of NIR fluorescent probes based upon the BF2 chelated tetraarylazadipyrromethene structure, which have the potential to act as biologically switchable off to on NIR fluorescent imaging agents.

Mentors Donal O'Shea.