Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Technology Cores & Research Facilities

The RCSI Research Institute is a multi-site research infrastructure encompassing the research activities of RCSI at the St Stephen's Green campus and the RCSI-Education and Research Centre (ERC) at Beaumont Hospital .

The research activities of RCSI Research Institute are sustained by an integrated research infrastructure consisting of a network of research centres and core facilities for genomics analysis, peptide synthesis and labelling, solid phase chemistry, proteomics, molecular, live cellular & human imaging, clinical research and biobanking.

Clinical Research: The Clinical Research Centre located on the grounds of Beaumont Hospital, provides general research laboratories, examination rooms, inpatient and outpatient beds, procedure rooms equipped for gene therapy and ancillary services consistent with a world-class research facility. More...

Genomic Analysis: The equipment available in this facility includes high throughput multiplex RT qPCR for analysis miRNA expression, high resolution microarrays (NimbleGen) for genome-wide analysis of DNA copy number alterations, DNA methylation, gene expression, and transcription factor binding sites. long-standing collaboration with R&D scientists at Roche-NimbleGen; Ultra-high resolution oligonucleotide microarray platform for analysis of DNA copy number alterations. Bioinformatics for integrated analysis of data from different NimbleGen microarray platforms (expression, DNA copy number, DNA methylation & transcription factor binding).For further details, please contact Prof Ray Stallings.

Molecular & Cellular Imaging: The equipment available in this facility includes live cell bi-photon, confocal & epi-fluorescence time lapse imaging, applications using FRET and FRAP, live cell high content screening, multi-parameter high throughput flow cytometry, cell sorting & high-resolution transmission electron microscopy. Automated microscopy based on real time image processing & analysis.More...

Small Animal Imaging: Specialised imaging capabilities include (1) in vivo imaging of small animal deep brain structures using 2-photon microscopy; (2) IVIS® Spectrum state-of-art small animal optical imaging system, providing bioluminescent & fluorescent imaging capabilities with 20 micron resolution. More...

Human Imaging: Specialised imaging capabilities include advanced human vascular & obstetric ultrasound, i.e. high resolution, three- and four-dimensional ultrasonography, tissue doppler and contrast ultrasonography, next-generation contrast agents (echogenicmicroparticles) & ultrasonic therapeutics. More...

Biobanking: RCSI Biobanking facilities includes the RCSI Biobank and the Dublin Brain Bank. More...

Peptide Synthesis and Labelling, Solid Phase Chemistry: provides expertise in organic-inorganic synthesis, peptide and peptidomimetic synthesis, drug design & medicinal chemistry. RCSI is an established international leader in design & preparation of low molecular weight families of bioactive compounds using diversity oriented synthetic strategies. It twins with the Institute for Bioimaging and Biostructures (IBB-Naples) which provides expertise & infrastructures for molecular modelling & X-ray crystallography of proteins & inorganic-organic compounds. More...