Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Employment and Studentship Opportunities

Please click on the links below to access more information regarding any job vacanices or postgraduate training opportunities with RCSI:

2 x Ph.D. Student Positions in Cancer Biology (Single Cell Imaging, AMPK signalling and Bioenergetics)

  • Apply by date - 31st July 2014

Centre for Systems Medicine (CSM) and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland (RCSI)

Prof Jochen Prehn

Project background and description:

The PhD student positions will be integrated into the Science Foundation Ireland-funded research group of Prof Jochen Prehn. Cancer cells have an altered energy metabolism. This may represent an alternative target for therapeutic intervention. Emerging evidence suggests that alterations in cellular bioenergetics may critically contribute to evasion of therapeutically-induced, genotoxic cell death. Data from our group suggested that cancer cells are able to restore energetic and ionic homeostasis even after the successful activation of cell death pathways. Our research and others has also shown that cellular bioenergetics influence the expression and activation of cell death-regulating proteins (BCL-2 family proteins), with the kinase, AMPK-activated protein kinase (AMPK), playing a key role in this process. The SFI-funded project seeks to identify, test, and validate new predictive and prognostic biomarkers for the treatment of CRC deriving from an integrated, validated, systems-based analysis of cellular bioenergetics, and their dependence on the mutational status of the tumour. The group has developed key systems models of apoptosis and bioenergetics, and is one of the few laboratories world-wide that has begun to translate these models into clinical settings.

The successful candidates will receive a tax-free stipend of €18.000 per annum. The positions are funded for three years commencing October 2014.

Please click on the below link to view the job description:
27 June PhD Students Cancer Research_JD