PRINCIPAL INVESTIGATORS (PI)

Prof David Henshall Associate Professor, Professor Physiology & Medical Physics, RCSI, 123 St Stephens Green Dublin 2 davhenshall@rcsi.ie
Prof Henshall's laboratory is interested in the cell and molecular mechanisms of brain injury in neurologic disorders such as epilepsy and stroke. Of particularly interest are the role of apoptosis-associated cell death signaling pathways. The group's research approach takes advantage of an array of experimental epilepsy models as well as human brain samples. Major projects are looking at the influence of genes regulating apoptosis on cell death after seziure, the genomic and proteomic responses of the brain to seizures and during the development of epilepsy and also examining experimental therapeutics which might prevent damage to brain after seizure and influence epilepsy itself.
Research Interests	Research Projects	Research Team	Publications	Collaborations	Honours and Awards	CV

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CONTACT DETAILS

Associate Professor, Professor
Physiology & Medical Physics, RCSI
123 St Stephens Green, Dublin 2
davhenshall@rcsi.ie
Telephone: 4028629
Mobile:
Fax: 4028639
Department Assistant: Patsy Connolly
Email: pconnolly2@rcsi.ie
Telephone:

EDUCATION
1997:	Doctor of Philosophy, Department of Pharmacology, University of Edinburgh, Edinburgh, UK. Neuropharmacology of ischemic brain injury.
1994:	Bachelor of Science, First Class, Department of Pharmacology, University of Bristol, Bristol, UK. Pharmacology

APPOINTMENTS
2009 to date:	Associate Professor, Royal College of Surgeons in Ireland Dublin, Ireland
2004 to 2008:	Senior Lecturer, Molecular Physiology & Neuroscience, Department of Physiology and Medical Physics , Royal College of Surgeons in Ireland Dublin, Ireland
2003 to 2004:	Associate Scientist, Robert S. Dow Neurobiology Laboratories, Legacy Health System Portland, Oregon, USA
1999 to 2002:	Assistant Scientist, Robert S. Dow Neurobiology Laboratories, Legacy Health System Portland, Oregon, USA
1997 to 1999:	Post-doctoral Fellow, Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

ACADEMIC ACTIVITY

1. Grant Reviewer (external), Academy of Finland 2. PhD Thesis Opponent Narkilahti S., A. I. Virtanen Institute, University of Kuopio, Finland 3. Grant Reviewer (ALW proposal), Netherlands Organisation for Scientific Research, Research Council for Earth and Life Sciences, The Hague, Netherlands 4. Grant Reviewer (Career Development Award), Department of Veterans Affairs, Washington, DC, USA 5. Grant Reviewer, HRB Clinical Fellowship Awards, Health Research Board, Ireland 6. Ad hoc Journal Reviewing: Acta Neurologica Scandinavica, Brain, Brain Research, Cell Biology International, Developmental Brain Research, Epilepsia, European Journal of Neuroscience, Journal of Cell Biology, Journal of Cerebral Blood Flow and Metabolism, Journal of Neurochemistry, Journal of Neuroscience, Journal of Neuroscience Methods, Journal of Neuroscience Research, Journal of Pharmacy and Pharmacology, Molecular Brain Research, Neurobiology of Disease, Neurochemistry International, Neurology, Neuroscience, Neuroscience Letters, Pediatric Research, Pharmacology Biochemistry & Behavior, Proceedings of the National Academy of Sciences USA, Stroke 7. External examiner for a PhD (University of Edinburgh) (2007) External examiner for a PhD (Trinity College Dublin) (2007) 8. Associate Editor, International Journal of Physiology, Pathophysiology and Pharmacology

SUMMARY OF RESEARCH CAREER TO DATE

Dr Henshall's undergraduate degree was from the University of Bristol, graduating with First Class Honours in Pharmacology in 1994. Postgraduate training on stroke modelling and neuronal injury was under Drs John Sharkey and Steve Butcher in the Department of Pharmacology and the Fujisawa Institute for Neuroscience at the University of Edinburgh, leading to the award of a PhD in Neuropharmacology in 1997. Post-doctoral training in cell death signaling in epilepsy was under Prof. Roger Simon at the Department of Neurology, University of Pittsburgh, USA. Following NIH funding in 1999, Dr Henshall was appointed Assistant Scientist at the newly established Robert S. Dow Neurobiology Laboratories, a private non-profit research institute in Portland, Oregon, USA. An RO1 award for research on apoptosis signaling in epilepsy established an expanded research team and in 2003, promotion to Associate Scientist. In early 2004, Dr Henshall moved to RCSI as Senior Lecturer in Molecular Physiology & Neuroscience. Dr Henshall has authored 57 papers and 3 book chapters. Current support is from Science Foundation Ireland, Marie Curie/FP6, Health Research Board, IRCSET and NIH/Legacy Health System, USA.

RESEARCH INTERESTS

Dr. Henshall's research aims to understand the gene-based regulation of neuronal cell death and hippocampal remodelling in epilepsy, and the influence of different seizure types. Particular focus is on characterizing the role of programmed (apoptotic) cell death pathways which are triggered by seizures, and evaluating their functional significance for post-injury brain remodeling and value as therapeutic targets. Studies utilize in vitro and in vivo experimental models, along with molecular biology, genomics/proteomics and imaging techniques. Combined translational neuroscience work using human brain material supports the induction of these complex signalling pathways after seizures in patient brain. Currently funded projects are investigating (i) role of Bcl-2 genes in the molecular pathogenesis of brain injury after seizures; (ii) Death receptor signaling in epilepsy, (ii) 14-3-3 proteins, (iii) genomics/proteomics of nerve cell injury and recovery, (iv) axon guidance genes in seizure susceptibility & epileptogenesis.

RESEARCH THEMES

Molecular pathogenesis of brain injury in epilepsy Apoptosis signaling in drug refractory epilepsy Development of novel animal models of epilepsy & stroke Impact of seizures in the developing brain (models of pediatric epilepsy) DNA damage and repair in neurological disorders Molecular mechanisms underlying of ischaemic preconditioning/tolerance. Identification of novel pharmacological and genetic neuroprotection strategies

MEMBERSHIPS

Neuroscience Ireland (2006)

Member, American Epilepsy Society (2005)

Member, International Society for Neurochemistry (2000)

Member, Society for Neuroscience (1998)

HONOURS/AWARDS/ACHIEVEMENTS
2004:	Principal Investigator Award, Science Foundation Ireland
1994:	James A.M. Kennedy Graduate Student Award, University of Edinburgh, UK
1993:	Nuffield Foundation Summer Student Award, University of Bristol, UK

ORAL PRESENTATIONS

Henshall D New targets in anti-epileptogenesis; targeting apoptosis signaling and beyond 61st American Epilepsy Society meeting, Philadelphia, USA (Dec 2007)

Henshall D Nuclear accumulation of CAD but not AIF suggests caspase-dependent pathways may overwhelm endogenous anti-apoptotic responses in human temporal lobe epilepsy Society for Neuroscience Annual Meeting, San Diego, CA, USA (Oct 2004)

Henshall D Apoptotic pathways and their contribution to seizure-induced neuronal death. Developmental CardioRespiratory Focus Group, Oregon Health Sciences University, Portland, Oregon, USA (Jan 2003)

Henshall D Caspase pathways mediating seizure-induced neuronal death Department of Pharmacology Invited Research Seminar, University of Bristol, U.K. (Apr 2001)

POSTER PRESENTATIONS

Henshall D, Shinoda S, Schindler C, Meller R, SO N, Araki T Bim regulation in seizure-induced neuronal death and temporal lobe epilepsy Molecular Mechanisms of Neurodegeneration, Biochemical Society Meeting, UCD, Dublin (Apr 2005)

Henshall D Bim regulation in seizure-induced neuronal death and temporal lobe epilepsy. Molecular mechanisms of neurodegeneration, Biochemical Society meeting., UCD, Dublin (Mar 2005)

Henshall D Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. The 5th International Cell Death Symposium, Maynooth, Ireland (Jun 2004)

Henshall D Overexpression of 14-3-3 may prevent epileptic brain injury by rebalancing seizure-induced 14-3-3 deficiency. 1st Gordon Conference on Biology of 14-3-3 proteins, Ventura, Colilfornia, USA (Feb 2004)

INVITED LECTURES

Henshall D Apoptosis signaling pathways in seizure-induced neuronal death and epilepsy Research Day, Centro de Biología Molecular "Severo Ochoa?, University of Madrid (Dec 2007)

Henshall D Apoptosis signaling in seizure-induced neuronal death and epilepsy Italian Society of Neuroscience, verona, Italy (Sep 2007)

Henshall D ?Apoptosis signaling pathways in seizure-induced neuronal death and epilepsy? Neuroscience Ireland (inaugural conference),, Univeristy College Cork, Cork, Ireland (Sep 2006)

Henshall D Workshop (organizer): Programmed cell death pathways in seizure-induced neuronal injury & epileptogenesis: human and animal data 7th European Congress on Epileptology, Helsinki, Finland (Jul 2006)

Henshall D Cell death and survival signalling in refractory temporal lobe epilepsy: Clinical data 8th International Neuroscience winter conference, Sölden, Austria (Mar 2006)

Henshall D Workshop: Seizure related programmed cell death (guest discussant). American Epilepsy Society Meeting, Washington, DC, USA. (Dec 2005)

Henshall D Apotosis signalling in epilespy:experimental and clinical data. Psychiatry & Neurology seminar series, Beaumont Hospital, Dublin, Ireland (Aug 2005)

Henshall D Seizure-induced brain injury:targeting apoptosis pathways. TCIN Neuroscience symposium, TCD, Dublin, Ireland (Jul 2005)

Henshall D Epilepsy & apoptosis pathways. Institute of Pharmacology & Toxicology, University of Zurich,Switzerland (Apr 2005)

Henshall D Role of caspases in seizure-induced brain injury & epileptogenesis Kuopio, Finland (Jan 2005)

Henshall D Use of stem cells in brain repair: lessons from epilepsy & beyond. Fighting blindness sponsored Irish Network of Neural Stem Cell Investigators, Dublin, Ireland (Dec 2004)

Henshall D Epilepsy & seizure-induced brain injury. Terling?s Park, Merck Research Laboratories, UK (Dec 2004)

Henshall D Animal models of seizure disorders: approaches to reproducing the apoptotic pathways functioning in temporal lobe epilepsy. Conway Institute, UCD (Apr 2004)

Henshall D Molecular Mechanisms opposing neuronal death following seizures. Programmed cell death mechanisms and seizure-induced neeuronal death panel. Spring Epilepsy Research Conference, Grand Cayman (Apr 2003)

PEER REVIEWED PUBLICATIONS

Engel T., Hatazaki S., Tanaka K., Prehn J.H., Henshall D.C. Deletion of puma protects hippocampal neurons in a model of severe status epilepticus. Neuroscience 168, 443-450 (2010).     PMID: 20362645      (Apr 2010)

Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma FASEB Journal 24, 853-861 (2010)     PMID: 19890018      (Mar 2010)

Dunleavy M, Shinoda S, Schindler C, Ewart C, Dolan R, Gobbo OL, Kerskens CM, Henshall DC. Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis. Am J Pathol 176, 330-342 (2010)     PMID: 19948825      (Dec 2009)

Tanaka K, Jimenez-Mateos E, Matsushima S, Taki W, Henshall DC. Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice. Epilepsy Res 88, 151-161 (2010)     PMID: 19931419      (Nov 2009)

Murphy B.M., Engel T., Paucard A., Hatazaki S., Mouri G., Tanaka K., Tuffy L.P., Jimenez-Mateos E., Woods I., Dunleavy M., Bonner H.P., Meller R., Simon R.P., Strasser A., Prehn J.H., Henshall D.C. Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex following status epilepticus Cell Death Differ 17, 459-468 (2010)     PMID: 19779495      (Sep 2009)

Henshall DC, Dürmüller N, White HS, Williams R, Moser P, Dunleavy M, Silverstone PH Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents. Neuropsychiatr Dis Treat 5, 189-206 2009     PMID: 19557114      (Apr 2009)

Kuroki K., Virard I., Concannon C.G., Engel T., Woods I, Taki W., Plesnila N., Henshall D.C., Prehn J.H. Effects of transient focal cerebral ischemia in mice deficient in puma Neurosci Lett (2009) 451: 237-40     PMID: 19159665      (Jan 2009)

Jimenez-Mateos EM, Hatazaki S, Johnson MB, Bellver-Estelles C, Mouri G, Bonner C, Prehn JH, Meller R, Simon RP, Henshall DC. Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiol Dis (2008) 32, 442-453     PMID: 18804535      (Sep 2008)

Murphy N, Yamamoto A, Henshall DC. Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures. Biomarkers. 13:377-84     PMID: 18484353      (Jul 2008)

Murphy N, Bonner HP, Ward MW, Murphy BM, Prehn JH, Henshall DC. Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures. J Neurochem. 2008 106, 978-988     PMID: 18466333      (May 2008)

Mouri G, Jimenez-Mateos E, Engel T, Dunleavy M, Hatazaki S, Paucard A, Matsushima S, Taki W, Henshall DC Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice Brain Res. 2008 1213, 140-151     PMID: 18455706      (Apr 2008)

O'Sullivan GJ, Dunleavy M, Hakansson K, Clementi M, Kinsella A, Croke DT, Drago J, Fienberg AA, Greengard P, Sibley DR, Fisone G, Henshall DC, Waddington JL Dopamine D(1) vs D(5) receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. Neuropharmacology 54:1051-61     PMID: 18367215      (Feb 2008)

Meller R, Torrey DJ, Thompson SJ, Ordonez AN, Ashley MD, Wang W, Henshall DC, Gafken P, Lusardi TA, Saugstad JA, Xiong ZG and Simon RP. Synaptic structural reorganization - a novel mechanism underlying rapid ischemic tolerance. J. Neurosci. 28, 50-59     PMID: 18171922      (Jan 2008)

Henshall DC and Murphy B. Modulators of neuronal cell death in epilepsy Curr Opinion Pharmacol 8:75-81.     PMID: 17827063      (Dec 2007)

Concannon C, Ward MW, Bonner HP, Kuroki K, Tuffy LP, Bonner CT, Woods I, Engel T, Henshall DC, Prehn JH. NMDA receptor-mediated excitotoxic neuronal injury in vitro and in vivo occurs in an ER Stress and PUMA independent manner J Neurochem 105:891-903     PMID: 18088354      (Nov 2007)

Simon R, Henshall D, Stohr S and Meller R. Endogenous mechanisms of neuroprotection Epilepsia 48 Suppl 8:72-3.     PMID: 18312252      (Nov 2007)

Murphy B, Dunleavy M, Shinoda S, Schindler CK, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Prehn JH, Simon RP and Henshall DC Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol 171:1258-68     PMID: 17702891      (Oct 2007)

Engel T, Murphy BM, Schindler CK, Henshall DC Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy Epilepsy Res. 77:151-6.     PMID: 17942278      (Oct 2007)

Hatazaki S, Bellver-Estelles C, Jimenez-Mateos E, Meller R, Bonner C, Murphy N, Matsushima S, Taki W, Prehn J, Simon RP, Henshall DC Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning. Neuroscience 150:467-77     PMID: 17935890      (Sep 2007)

Henshall DC Apoptosis signalling pathways in seizure-induced neuronal death and epilepsy. Biochem Soc. Proc. 35(2), 421-423     PMID: 17371290      (Apr 2007)

Rosenzweig HL, Minami M, Lessov NS, Coste S, Stevens SL, Henshall DC, Meller R, Simon RP and Stenzel-Poore MP. Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha following stroke: A novel role for TNFalpha in LPS-ischemic tolerance. J. Cereb Blood Flow Metab. 27:1663-74.     PMID: 17327883      (Feb 2007)

Yamamoto A, Schindler CK, Murphy BM, Bellver-Estelles C, So NK, Taki W, Meller R, Simon RP, Henshall DC. Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy Exp Neurol. 202, 41-420     PMID: 16919273      (Dec 2006)

Schindler CK, Heverin M, Henshall DC. Isoform- and subcellular fraction-specific differences in hippocampal 14-3-3 levels following experimentally evoked seizures and in human temporal lobe epilepsy. J. Neurochem. 99, 561-569     PMID: 16981892      (Oct 2006)

Meller R, Clayton C, Torrey D, Schindler CK, Lan JQ, Cameron J, Chu XP, Xiong ZG, Simon RP, Henshall DC. Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons. Epilepsy Res. 70(1):3-14     PMID: 16542823      (Jul 2006)

Yamamoto A, Murphy N, Schindler CK, So NK, Stohr S, Taki W, Prehn JH and Henshall DC. Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy. J. Neuropathol. Exp. Neurol. 65(3):217-25     PMID: 16651883      (Mar 2006)

Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA and Simon RP. Rapid degradation of bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultures neurons. J Biol Chem;281(11):7429-36     PMID: 16431916      (Jan 2006)

Henshall DC, Simon RP Epilepsy and apoptosis pathways. J Cereb Blood Flow Metab; 25(12):1557-1572     PMID: 15889042      (Dec 2005)

Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. J Cereb Blood Flow Metab;26(4):583-9     PMID: 16121124      (Aug 2005)

Meller R, Minami M, Cameron JA, Impey S, Chen D, Lan JQ, Henshall DC, Simon RP CREB-mediated Bcl-2 protein expression after ischemic preconditioning. J Cereb Blood Flow Metab;25(2):234-46     PMID: 15647742      (Feb 2005)

Rosenzweig HL, Lessov NS, Henshall DC, Minami M, Simon RP, Stenzel-Poore MP Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke;35(11):2576-81     PMID: 15375302      (Nov 2004)

Henshall DC, Schindler CK, So NK, Lan JQ, Meller R, Simon RP Death-associated protein kinase expression in human temporal lobe epilepsy. Ann Neurol;55(4):485-94     PMID: 15048887      (Apr 2004)

Shinoda S, Araki T, Lan JQ, Schindler CK, Simon RP, Taki W, Henshall DC Development of a model of seizure-induced hippocampal injury with features of programmed cell death in the BALB/c mouse. J Neurosci Res;76(1):121-8     PMID: 15048936      (Apr 2004)

Shinoda S, Schindler CK, Meller R, So NK, Araki T, Yamamoto A, Lan JQ, Taki W, Simon RP, Henshall DC Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest;113(7):1059-68     PMID: 15057313      (Apr 2004)

Schindler CK, Shinoda S, Simon RP, Henshall DC Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Neurosci Lett;356(3):163-6     PMID: 15036620      (Feb 2004)

Araki T, Shinoda S, Schindler CK, Quan-Lan J, Meller R, Taki W, Simon RP, Henshall DC Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures. Hippocampus;14(3):326-36     PMID: 15132432      (Jan 2004)

Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A;101(1):343-7     PMID: 14660786      (Jan 2004)

Henshall DC, Araki T, Schindler CK, Shinoda S, Lan JQ, Simon RP Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem;86(5):1260-70     PMID: 12911633      (Sep 2003)

Shinoda S, Schindler CK, Quan-Lan J, Saugstad JA, Taki W, Simon RP, Henshall DC Interaction of 14-3-3 with Bid during seizure-induced neuronal death. J Neurochem;86(2):460-9     PMID: 12871587      (Jul 2003)

Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci;17(10):2065-76     PMID: 12786973      (May 2003)

Meller R, Schindler CK, Chu XP, Xiong ZG, Cameron JA, Simon RP, Henshall DC Seizure-like activity leads to the release of BAD from 14-3-3 protein and cell death in hippocampal neurons in vitro. Cell Death Differ;10(5):539-47     PMID: 12728252      (May 2003)

Liou AK, Clark RS, Henshall DC, Yin XM, Chen J To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol;69(2):103-42     PMID: 12684068      (Feb 2003)

Chen D, Minami M, Henshall DC, Meller R, Kisby G, Simon RP Upregulation of mitochondrial base-excision repair capability within rat brain after brief ischemia. J Cereb Blood Flow Metab;23(1):88-98     PMID: 12500094      (Jan 2003)

Henshall DC, Araki T, Schindler CK, Lan JQ, Tiekoter KL, Taki W, Simon RP Activation of Bcl-2-associated death protein and counter-response of Akt within cell populations during seizure-induced neuronal death. J Neurosci;22(19):8458-65     PMID: 12351720      (Oct 2002)

Araki T, Simon RP, Taki W, Lan JQ, Henshall DC Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse. J Neurosci Res;69(5):614-21     PMID: 12210827      (Sep 2002)

Henshall DC, Skradski SL, Meller R, Araki T, Minami M, Schindler CK, Lan JQ, Bonislawski DP, Simon RP Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Neurobiol Dis;10(2):71-87     PMID: 12127146      (Jul 2002)

Meller R, Skradski SL, Simon RP, Henshall DC Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Neurosci Lett;324(1):33-6     PMID: 11983288      (May 2002)

Henshall DC, Bonislawski DP, Skradski SL, Araki T, Lan JQ, Schindler CK, Meller R, Simon RP Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. Cell Death Differ;8(12):1169-81     PMID: 11753565      (Dec 2001)

Henshall DC, Bonislawski DP, Skradski SL, Lan JQ, Meller R, Simon RP Cleavage of bid may amplify caspase-8-induced neuronal death following focally evoked limbic seizures. Neurobiol Dis;8(4):568-80     PMID: 11493022      (Aug 2001)

Henshall DC, Skradski SL, Lan JQ, Ren T, Simon RP Increased Bcl-w expression following focally evoked limbic seizures in the rat. Neurosci Lett;305(3):153-6     PMID: 11403928      (Jun 2001)

Henshall DC, Skradski SL, Bonislawski DP, Lan JQ, Simon RP Caspase-2 activation is redundant during seizure-induced neuronal death. J Neurochem;77(3):886-95     PMID: 11331417      (May 2001)

Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP, Chen J Induction of oxidative DNA damage in the peri-infarct region after permanent focal cerebral ischemia. J Neurochem;75(4):1716-28     PMID: 10987855      (Oct 2000)

Henshall DC, Clark RS, Adelson PD, Chen M, Watkins SC, Simon RP Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy. Neurology;55(2):250-7     PMID: 10908900      (Jul 2000)

Nagayama T, Simon RP, Chen D, Henshall DC, Pei W, Stetler RA, Chen J Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J Neurochem;74(4):1636-45     PMID: 10737622      (Apr 2000)

Henshall DC, Chen J, Simon RP Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J Neurochem;74(3):1215-23     PMID: 10693954      (Mar 2000)

Henshall DC, Sinclair J, Simon RP Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures. Brain Res;858(2):290-302     PMID: 10708680      (Mar 2000)

Minami M, Jin KL, Li W, Nagayama T, Henshall DC, Simon RP Bcl-w expression is increased in brain regions affected by focal cerebral ischemia in the rat. Neurosci Lett;279(3):193-5     PMID: 10688062      (Feb 2000)

Lan J, Henshall DC, Simon RP, Chen J Formation of the base modification 8-hydroxyl-2'-deoxyguanosine and DNA fragmentation following seizures induced by systemic kainic acid in the rat. J Neurochem;74(1):302-9     PMID: 10617133      (Jan 2000)

Henshall DC, Sinclair J, Simon RP Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy. J Neurochem;73(4):1573-83     PMID: 10501203      (Oct 1999)

Henshall DC, Butcher SP, Sharkey J A rat model of endothelin-3-induced middle cerebral artery occlusion with controlled reperfusion. Brain Res;843(1-2):105-11     PMID: 10528116      (Oct 1999)

Kawaguchi K, Henshall DC, Simon RP Parallel dose-response studies of the voltage-dependent Na+ channel antagonist BW619C89, and the voltage-dependent Ca2+ channel antagonist nimodipine, in rat transient focal cerebral ischaemia. Eur J Pharmacol;364(2-3):99-105     PMID: 9932711      (Jan 1999)

Tanaka K, Henshall DC, Waga S, Shimosaka S, Simon RP Bilateral intranigral NMDA infusion suppresses neuronal injury without affecting the duration of kainic acid-induced seizures in rats. Neurosci Lett;251(1):69-71     PMID: 9714467      (Jul 1998)

Butcher SP, Henshall DC, Teramura Y, Iwasaki K, Sharkey J. Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. J Neurosci;17(18):6939-46     PMID: 9278529      (Sep 1997)

BOOK CHAPTERS

Henshall DC Apoptosis signalling pathways, neuronal death and epilepsy In: Modern insights into Disease: Apoptosis. Science Publishers      (Aug 2009)

Henshall DC and Simon RP Molecular mechanisms of cell death after seizures. Encyclopedia of Basic Epilepsy Research. Edited by P. Schwartzkroin. Elsevier, Oxford, UK      (Aug 2008)

Henshall DC The double-hit hypothesis: is it clinically relevant? In: Epilepsy Case Studies: Clinical challenges and basic solutions (Ed. Schmidt & Schachter)      (Dec 2007)

THESES

Student Name: Gary Brennan (PhD / 3 yrs) Thesis Title: Role of 14-3-3 in seizure-induced neuronal death and epilepsy development in mice?. Awarding Institution:

Student Name: Claire Ewart (PhD / 4 yrs) Thesis Title: Imaging Brain Damage and Repair Responses in Experimental Paediatric Epilepsy Awarding Institution:

Student Name: Zuzanna Michalak (PhD / 3 yrs) Thesis Title: IgG ACCUMULATION IN NEURONS OF THE CHRONIC EPILEPTIC FOCUS: AUTOIMMUNITY AND/OR TOXICITY? Awarding Institution:

Student Name: Ross McKiernan (PhD / 3 yrs) Thesis Title: Awarding Institution:

Student Name: Aurelien Caballero (PhD / 3 yrs) Thesis Title: Mitochondrial bioenergetics control by the FoxO3 transcription factor Awarding Institution:

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