PRINCIPAL INVESTIGATORS (PI)

Dr Markus Rehm Lecturer, Research Lecturer Physiology & Medical Physics, RCSI, York House - York Street Dublin 2 mrehm@rcsi.ie
Dr. Markus Rehm leads an independent research group at the Royal College of Surgeons since 2005. He is appointed as Research Lecturer in Physiology and Biophysics. His Experimental Systems Biology group is part of the Department of Physiology and Medical Physics. Currently, the group of Dr. Rehm consists of 4 PhD students and 2 postdoctoral researchers covering expertise in Biochemistry, Biophysics, Molecular Imaging, and Computational Modeling. Dr. Rehm's group has established and utilized quantitative biochemistry and confocal and FRET-based imaging systems in combination with cell biological methods to monitor key processes during apoptosis execution in human cancer cells. This research in combination with complex computational systems analyses provides functional insight into the mechanisms of tumor resistance.
Research Interests	Research Projects	Research Team	Publications	Collaborations	Honours and Awards	CV

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PEER REVIEWED PUBLICATIONS

Würstle ML, Laussmann MA, Rehm M The Caspase-8 Dimerisation/Dissociation Balance is a highly potent Regulator of the Caspase-8, -3, -6 Signalling Loop J Biol Chem. 2010 Aug 11     PMID: 20702410      (Aug 2010)

Flanagan L, Sebastià J, Tuffy LP, Spring A, Lichawska A, Devocelle M, Prehn JH, Rehm M XIAP impairs Smac Release from the Mitochondria during Apoptosis Cell Death & Disease     PMID: 1, e49; doi:10.1038/cddis.2010.26      (Jun 2010)

Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M Activity of Protein Kinase CK2 uncouples Bid cleavage from Caspase-8 activation J Cell Sci. 2010 May 1;123(Pt 9):1401-6. Epub 2010 Mar 31     PMID: 20356928      (Mar 2010)

Huber HJ, Laussmann MA, Prehn JH, Rehm M Diffusion is capable of translating anisotropic Apoptosis Initiation into a homogeneous Execution of Cell Death BMC Syst Biol. 2010 Feb 4;4(1):9. [Epub ahead of print]     PMID: 20132548      (Jan 2010)

Wenus J, Dussmann H, Paul P, Kalamatianos D, Rehm M, Wellstead P, Prehn JH, Huber HJ ALISSA - An Automated Live-Cell Imaging System for Signal-Transduction Analyses Biotechniques. 2009 Dec;47(6):1033-40     PMID: 20041856      (Dec 2009)

Dussmann H, Rehm M, Concannon CG, Anguissola S, Wurstle M, Kacmar S, Voller P, Huber HJ, Prehn JH Single-Cell Quantification of Bax Activation and Mathematical Modeling Suggest Pore Formation upon Minimal Mitochondrial Bax Accumulation Cell Death Differ. 2009, Sep 11. [Epub ahead of print]     PMID: 19745831      (Sep 2009)

Anguissola S, Köhler B, O?Byrne R, Düssmann H, Rehm M, Kögel D, Prehn JH Bid and Calpains cooperate to trigger Oxaliplatin-induced Apoptosis of Cervical Carcinoma HeLa Cells Mol Pharmacol. 2009 Aug 27. [Epub ahead of print]     PMID: 19713356      (Aug 2009)

Rehm M, Huber HJ, Hellwig CT, Anguissola S, Dussmann H, Prehn JH Dynamics of Outer Mitochondrial Membrane Permeabilization during Apoptosis Cell Death Differ. 2009 Apr;16(4):613-23. Epub 2009 Jan 9.     PMID: 19136937      (Apr 2009)

Farrelly AM, Wobser H, Bonner C, Anguissola S, Rehm M, Concannon CG, Prehn JH, Byrne MM Early loss of mammalian target of rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha (HNF1A) function in INS-1 insulinoma cells Diabetologia. 2009 Jan;52(1):136-44. Epub 2008 Oct 24     PMID: 18949455      (Oct 2008)

O'Connor CL, Anguissola S, Huber HJ, Dussmann H, Prehn JH, Rehm M Intracellular signaling dynamics during apoptosis execution in presence or absence of X-linked-inhibitor-of-apoptosis-protein Biochim Biophys Acta. 2008 Oct;1783(10):1903-13     PMID: 18590777      (Oct 2008)

Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JH, Vogler M, Fulda S, Vollmar AM Cephalostatin-mediated apoptosis is Smac-dependent and involves assembly of the PIDDosome. Cell Death Differ. 2008 Dec;15(12):1930-40. Epub 2008 Sep 19.     PMID: 18806754      (Sep 2008)

Huber HJ, Plchut M, Weisova P, Dussmann H, Rehm M, Ward MW, Prehn JH TOXI-SIM ? A simulation tool for the analysis of mitochondrial and plasma membrane potentials J Neurosci Methods. 2009 Jan 30;176(2):270-5. Epub 2008 Sep 7.     PMID: 18824028      (Sep 2008)

Köhler B, Anguissola S, Concannon CG, Rehm M, Kögel D, Prehn JH Bid participates in genotoxic drug-induced apoptosis of cervical cancer HeLa cells and is essential for the apoptotic and synergistic effects of death receptor ligands PLoS One. 2008 Jul 30;3(7):e2844.     PMID: 18665234      (Aug 2008)

Hellwig CT, Kohler BF, Lehtivarjo A, Dussmann H, Courtney MJ, Prehn JH, Rehm M Real-time analysis of TRAIL/CHX-induced caspase activities during apoptosis initiation J Biol Chem. 2008 Aug 1;283(31):21676-85. Epub 2008 Jun 3.     PMID: 18522940      (Jun 2008)

Konig HG, Rehm M, Gudorf D, Krajewski S, Gross A, Ward MW, Prehn JH Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons. BMC Cell Biol. 2007 Feb 27;8:7.     PMID: 17326836      (Feb 2007)

Huber HJ, Rehm M, Plchut M, Dussmann H, Prehn JH APOPTO-CELL - A simulation tool and interactive database for analyzing cellular susceptibility to apoptosis Bioinformatics. 2007 Mar 1;23(5):648-50. Epub 2007 Jan 19     PMID: 17237051      (Jan 2007)

Rehm M, Huber H, Dussmann H, Prehn JH Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein EMBO J. 2006 Sep 20;25(18):4338-49     PMID: 16932741      (Sep 2006)

Ward MW, Rehm M, Duessmann H, Kacmar S, Concannon CG, Prehn JH Real time single cell analysis of BID cleavage and BID translocation during caspase-dependent and neuronal caspase-independent apoptosis J Biol Chem;281(9):5837-44     PMID: 16407197      (Dec 2005)

Rehm M, Dussmann H, Prehn JH Real-time single cell analysis of Smac/DIABLO release during apoptosis J Cell Biol 162(6):1031-43     PMID: 12975347      (Sep 2003)

Dussmann H, Kogel D, Rehm M, Prehn JH Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis J Biol Chem 278(15):12645-9     PMID: 12560329      (Apr 2003)

Dussmann H, Rehm M, Kogel D, Prehn JH Outer mitochondrial membrane permeabilization during apoptosis triggers caspase-independent mitochondrial and caspase-dependent plasma membrane potential depolarization: a single-cell analysis J Cell Sci 116(Pt 3):525-36     PMID: 12508113      (Feb 2003)

Rehm M, Dussmann H, Janicke RU, Tavare JM, Kogel D, Prehn JH Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3 J Biol Chem 277(27):24506-14     PMID: 11964393      (Jul 2002)

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