PRINCIPAL INVESTIGATORS (PI)
Prof John Waddington

Head of Department, Professor
Molecular & Cellular Therapeutics,
RCSI,
123 St Stephens Green
Dublin 2


jwadding@rcsi.ie

Following undergraduate and postgraduate studies in neuroscience and a period on the scientific staff of the UK Medical Research Council, my academic career in RCSI now involves directing a multidisciplinary research group that enjoys a distinguished international reputation in both preclinical and clinical neuroscience. Our primary focus is on psychotic illness [schizophrenia and bipolar disorder] and the application of mutant models to understand the developmental pathobiology of psychosis and antipsychotic drug action.
Research Interests Research Projects Research Team Publications Collaborations Honours and Awards CV

RESEARCH PROJECTS

Project Title Project Description Leading PI Co investigators Funding Source
Studies on the mechanism of action of neuroleptic drugs: identification of specific molecular components involved in the generation of tardive dyskinesia Waddington John, RCSI IRCSET - Embark post-doctoral fellowship (Kerstin Hakansson)
Resource for Psychiatric Genomics in Ireland: accessing disruption to early brain development and quantifying it's relationship to functional impairment through morphometrics Waddington John, RCSI HRB - Equipment grant
Examination of the genetic basis of schizophrenia: focus on neuregulin Click here for Project Description Waddington John, RCSI John Waddington, RCSI
SFI UREKA
Neurosurgery Waddington John, RCSI Various sources (incl Stanley Foundation)
Targeted gene deletion of dopamine receptor subtypes and associated transduction mechanisms: systematic comparison of functional phenotype and platforms for drug discovery in congenic ?knockouts?? Waddington John, RCSI SFI - Supplement award (equipment)
The analysis of three-dimensional facial dysmorphology Click here for Project Description Waddington John, RCSI Wellcome Trust Project Grant
Resource for Psychiatric Genomics Ireland Waddington John, RCSI Wellcome Trust
Targeted disruption of genes related to neuropsychiatric disease and translational phenotypes Click here for Project Description Waddington John, RCSI SFI Investigator Programme Grants
Schizophenia/bipolar Waddington John, RCSI Various funding sources
Schizophenis Waddington John, RCSI Various funding sources

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