Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Research Strategy

The primary research focus of the Department of Physiology and Medical Physics is the analysis of Cell Death and Cell Survival Signalling and its application to Neurological Disorders, Oncology and Diabetes. We use molecular imaging, proteomics and computational biology to accelerate discovery and translation of research findings into the clinic.

The Department has successfully established an internationally recognised centre of excellence and a significant critical mass in the fields of:

  • Mechanisms of neurological disorders in vitro, in vivo and in humans and the scientific basis for new therapeutic approaches towards these disorders.
  • Apoptosis and cell death signalling as novel prognostic and therapeutic targets in neurological disorders, oncology and diabetes.
  • Single cell imaging and systems biology approaches to understand biological systems and biological outcomes in neurons and cancer cells.


Prof. Jochen Prehn, the Head of Physiology and Medical Physics, is the co-ordinator of two Centres of Research in the Department. These are now established and internationally recognised centres of excellence with a significant critical mass in the two fields of expertise.

  • The remit of the Centres is to:
  • Reinforce research in the two key areas
  • To provide shared facilities
  • To attract co-funding and joint commercialisation partners.