Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Neuropsychiatric disorders

Disorders of the central nervous system are among the most debilitating of human conditions, at the level of the individual, family, society and the economy.

In Molecular and Cellular Therapeutics we are studying two major domains of neuropsychiatric disorder: epilepsy and psychotic illness. Dr Gianpiero Cavalleri and Prof. Norman Delanty are studying the neurobiology of epilepsy at several levels, with particular focus on the relationship of genetic predisposition to structural brain abnormalities, their underlying cellular pathology and the adverse effects of antiepileptic drugs. Prof. John Waddington is studying the pathobiology of schizophrenia, bipolar disorder and related neurodevelopmental disorders, with a particular focus on an underlying developmental unity to psychotic diagnoses and the adverse consequences of delayed treatment.

In addition to their College-based programmes, Dr Cavalleri and Profs. Delanty and Waddington are members of large, collaborative networks that include international consortia dedicated to unraveling the nature of genetic risk for epilepsy and for psychotic illness; these have resulted in recent publications in Nature, Nature Genetics, Nature Medicine and Proceedings of the National Academy of Sciences USA.