Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

MCT Publications 2010-2016

2016

  • Al Hannan FA, O'Farrell PA, Morgan MP, Tighe O, Culligan KG. Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk in Bahraini individuals. East Mediterr Health J. 2016 Nov 2;22(8):611-618.  PMID: 27834443.
  • Alhusaini S, Whelan CD, Doherty CP, Delanty N, Fitzsimons M, Cavalleri GL. Temporal cortex morphology in mesial temporal lobe epilepsy patients and their asymptomatic siblings. Cereb Cortex. 2016;26(3):1234-41. PMID: 25576532.
  • Bajrangee A, Ryan N, Vangjeli C, Brennan M, Cox D, Shields DC, Fitzgerald D, Maree A.  Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin.  Thromb Res. 2016 Oct;146:51-55. PMID: 27597145.
  • Behan LA, Carmody D, Rogers B, Hannon MJ, Davenport C, Tormey W, Smith D, Thompson CJ, Stanton A, Agha A. Low dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotropin (ACTH) deficient hypopituitary male patients. European Journal of Endocrinology 2016;174(6):791-9. PMID:27025241.
  • Bigdeli, T.B. et al [including Waddington, JL.]. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. Am J Med Genet B Neuropsychiatr Genet. 2016 Mar;171B:276-89. PMID: 26663532.
  • Burke N, Flood K, Muellers S, Murray A, Dunne E, Cotter B, Dempsey M, Dicker P, Geary MP, Kenny D, Malone FD. Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome. Eur J Obstet Gynecol Reprod Biol. 2016;199:132-6.  PMID: 26927895.
  • Cowman J, Quinn N, Geoghegan S, Müllers S, Olgesby I, Byrne B, Somers M, Ralph A, Voisin B, Ricco AJ, Molloy EJ, Kenny D. Dynamic platelet function on von Willebrand factor is different in preterm neonates compared with full-term neonates: changes in neonatal platelet function.  J Thromb Haemost. 2016 Oct;14(10):2027-2035  PMID: 27416003.
  • Dempsey MA, Flood K, Burke N, Murray A, Cotter B, Muellers S, Dicker P, Fletecher P, Geary M, Malone FD, Kenny D.   Viable pregnancies beyond 28 weeks gestation in women with a history of unexplained recurrent miscarriage have reduced platelet function.  Eur J Obstet Gynecol Reprod Biol. 2016 May;200:76-81. PMID: 26994466. 
  • Dunne E, Egan K, McFadden S, Foley D. & Kenny D.  Platelet aggregation in response to ADP is highly variable in normal donors and patients on anti-platelet medication. Clin Chem Lab Med. 2016 Jul 1;54(7):1269-73 . PMID: 26562035.
  • Early JOCurtis AM.  Immunometabolism: Is it under the eye of the clock? Semin Immunol. 2016 Oct;28(5):478-490.  PMID: 27884543.
  • Ehret GB, et al [including Stanton AV]. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 Oct;48(10):1171-84PMID: 27618452.
  • Fountoulakis KN, et al [including Grady A, Waddington JL.]. Relationship of suicide rates with climate and economic variables in Europe during 2000-2012. Ann Gen Psychiatry. 2016 Aug 9;15:19. PMID: 27508001.
  • Franke, B. et al, [incl. Cavalleri G, Delanty N, Waddington JL.]. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci. 2016 Mar;19(3):420-31. PMID: 26854805
  • Garciarena C, McHale T, Watkin R, Kerrigan SW. Coordinated molecular cross-talk between staphylococcus aureus, endothelial cells and platelets in bloodstream infection. Pathogens. 2015;4(4):869-82. PMID: 26690226. 
  • Jimenez-Pacheco A, [including Delanty N].  Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy. J Neurosci. 2016 Jun 1;36(22):5920-32. PMID: 27251615.
  • Jose B, McCluskey P, Gilmartin N, Somers M, Kenny D, Ricco AJ, Kent NJ, Basabe-Desmonts L.  Self-powered microfluidic device for rapid assay of antiplatelet drugs. Langmuir. 2016;32(11):2820-8. PMID: 26910300.
  • Kanoni S, et al. [including Stanton AV].   Analysis with the exome array identifies multiple new independent variants in lipid loci.    Hum Mol Genet. 2016 Sep 15;25(18):4094-4106.  PMID:  27466198.
  • Kelly GJ, A. Foltyn-Arfa Ki, Hassan F, O’Grady S, Morgan MP, Creaven BS, McClean S, Harmey JS and Devocelle M. Polymeric prodrugs combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells.  Org Biomol Chem. 2016 Oct 4;14(39):9278-9286.   PMID: 27722734. 
  • Kiguchi Y, Aono Y, Watanabe Y, Yamamoto-Nemoto S, Shimizu K, Shimizu T, Kosuge Y, Waddington JL, Ishige K, Ito Y, Saigusa T. In vivo neurochemical evidence that delta1-, delta2- and mu2-opioid receptors, but not mu1-opioid receptors, inhibit acetylcholine efflux in the nucleus accumbens of freely moving rats.  Eur J Pharmacol. 2016 Jul 18;789:402-410. PMID: 27445235. 
  • Kobulashvili T, et al [including Delanty N].   Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery. Seizure. 2016 May;38:38-45. PMID: 27104922.
  • Lazaridis I, et al,  [incl. Cavalleri G.].   Genomic insights into the origin of farming in the ancient Near East. Nature. 2016 Aug 25;536(7617):419-24.  PMID: 27459054
  • MacMullan PA, Madigan AM, Paul N, Peace AJ, Alagha A, Nolan KB, McCarthy GM, Kenny D.   Sulfasalazine and its metabolites inhibit platelet function in patients with inflammatory arthritis.  Clin Rheumatol. 2016;35(2):447-55.  PMID; 25253538.    
  • Mehta D, et al [including Waddington J]. Evidence for genetic overlap between schizophrenia and maternal age at first birth. JAMA Psychiatry. 2016 May 1;73(5):497-505. PMID: 27007234.
  • Michaut M, [including O'Connor DP].  Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer. Sci Rep. 2016 Jan 5;6:18517.  PMID: 26729235.
  • Mone F, Mulcahy C, McParland P, Stanton A, Culliton M, Downey P, McCormack D, Tully E, Dicker P, Breathnach F, Malone FD, McAuliffe FM. An open-label randomized-controlled trial of low dose aspirin with an early screening test for pre-eclampsia and growth restriction (TEST): Trial protocol. Contemporary Clinical Trials 2016; 49: 143–148. PMID: 27394381. 
  • Müllers SM, Burke N, Flood K, Cowman J, O'Connor H, Cotter B, Kearney M, Dempsey M, Dicker P, Tully E, Geary MP, Kenny D, Malone FD. Altered platelet function in intrauterine growth restriction:  A cause or a consequence of uteroplacental diseaseAm J Perinatol. 2016 Jul;33(8):791-9PMID: 26906182.
  • Omer S, Finnegan M, Pringle DG, Kinsella A, Fearon P, Russell V, O’Callaghan E, Waddington JL. Socioeconomic status at birth and risk for first episode psychosis in rural Ireland: eliminating the features of urbanicity in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). Schizophr Res. 173, 84-9, 2016.  PMID: 26995673.
  • O’Tuathaigh CM, Waddington JL.  Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness. Neurosci Biobehav Rev. 2015;58:19-35. PMID: 25616181
  • Parker JP, Devocelle M, Morgan MP, Marmion CJ. Derivatisation of buforin IIb, a cationic henicosapeptide, to afford its complexation to platinum(ii) resulting in a novel platinum(ii)-buforin IIb conjugate with anti-cancer activity.   Dalton Trans. 2016 Aug 16;45(33):13038-41. PMID: 27292799.
  • Ryan E, Colleran N, Cullinane P, Fitzsimons M, Flynn F, Delanty N, Hennessy M.  Perampanel: An audit of clinical experience using the epilepsy electronic patient record.Ir Med J. 2016 Aug 8;109(7):437. PMID: 27834088.
  • Sekar, A. et al, [incl. Waddington, JL.].  Schizophrenia risk from complex variation of complement component 4.  Nature. 2016 Feb 11;530(7589):177-83.    PMID: 25642630.
  • Shah E, Reuber M, Goulding P, Flynn C, Delanty N, Kemp S. Clinical experience with adjunctive perampanel in adult patients with uncontrolled epilepsy: A UK and Ireland multicentre study. Seizure. 2016 Jan;34:1-5. PMID: 26615577.
  • Smith A, Murphy L, Sharp L, O'Connor DP, Gallagher WM, Bennett K, Barron TI. De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I-III breast cancer. Br J Cancer. 2016 Aug 23;115(5):592-8. PMID: 27482648.
  • Surendran P. [including Stanton AV].  Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet. 2016 Oct;48(10):1151-61. PMID: 27618447.
  • Tropea D, Molinos I, Petit E, Bellini S, Nagakura I, O'Tuathaigh C, Schorova L, Mitchell K, Waddington J, Sur M, Gill M, Corvin A. Disrupted in schizophrenia 1 (DISC1) L100P mutants have impaired activity-dependent plasticity in vivo and in vitro. Transl Psychiatry. 2016;6:e712. PMID: 26756905. 
  • Van Voorhis WC, et al [incl. Brennan]. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016; 12(7):e1005763. PMID: 2746575. 
  • Vilhjálmsson, B.J. et al [including Waddington JL.[. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am J Hum Genet. 2015 Oct 1;97,576-92. PMID: 26430803. 
  • Watson CN, Kerrigan SW, Cox D, Henderson IR, Watson SP, Arman M. Human platelet activation by Escherichia coli: roles for FcgRIIa and integrin alphaIIb beta3. Platelets. 2016; 27(6):535-40. PMID: 27025455.
  • Webster R. et al [including Stanton AV.].  Effectiveness of fixed dose combination medication ('polypills') compared with usual care in patients with cardiovascular disease or at high risk: A prospective, individual patient data meta-analysis of 3140patients in six countries. Int J Cardiol. 2016 Feb 15;205:147-56.  PMID: 26736090.

Reviews

  • Clarke M, McDonough CM, Doyle R, Waddington JL. Are we really impacting duration of untreated psychosis and does it matter: perspectives from the Irish public health services. Psychiatr Clin North Am. 2016;39(2):175-86. PMID: 27216898.
  • Curigliano G, O'Connor DP, Rosenberg JA, Jacobs I. Biosimilars: Extrapolation for oncology. Crit Rev Oncol Hematol. 2016 Aug;104:131-7. PMID: 27354233.
  • Katina S, McNeil K, Ayoub A, Guilfoyle B, Khambay B, Siebert P, Sukno F, Rojas M, Vittert L, Waddington JL, Whelan PF, Bowman AW. The definitions of three-dimensional landmarks on the human face: an interdisciplinary view. J Anat. 2016;228(3):355-65. PMID: 26659272.
  • Walsh L, Gallagher WM, O'Connor DP*, Ní Chonghaile T*. Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer. Expert Rev Mol Diagn. 2016;16(5):541-51. *Shared Senior Authorship. PMID: 26895288. 

 

Book chapters

  • Kerrigan SW. Platelets as immune regulators in cardiovascular infection. In: Kerrigan SW & Moran N (eds). The non-thrombotic role of platelets in health and disease. InTech Publishers, Chpt 4, pp. 65-84, 2016. 
  • O’Sullivan B, Kerrigan SW. The role of platelets in respiratory disease. In: Kerrigan SW & Moran N (eds). The non-thrombotic role of platelets in health and disease. InTech Publishers, Chpt 7, pp.137-58, 2016.
  • Piskareva O, Stallings R. Neuroblastoma. In: Epigenetic Cancer Therapy Grey S.(eds). Elsevier. Chpt 13 Neuroblastoma. pp. 289-316, 2016. 
  • Waddington JL. Modeling dimensions of psychopathology: integration with the epidemiology and pathobiology of psychotic illness. In: Pletnikov MV, Waddington JL (eds). Modeling the Psychopathological Dimensions of Schizophrenia: from Molecules to Behavior. New York: Elsevier. pp. 33–38, 2016.

2015

  • Allen S, Moran N. Cell adhesion molecules: Therapeutic targets for inhibition of inflammatory states. Semin Thromb Hemost. 2015;41(6):563-71.
  • Alonso AL, Cox D. Platelet interactions with viruses and parasites. Platelets 2015;26(4):317-23.
  • Alhusaini S, Whelan CD, Doherty CP, Delanty N, Fitzsimons M, Cavalleri GL. Temporal cortex morphology in mesial temporal lobe epilepsy patients and their asymptomatic siblings. Cereb Cortex. 2016 Mar;26(3):1234-41.
  • Batini C, et al [including Cavalleri GL]. Large-scale recent expansion of European patrilineages shown by population resequencing.  Nat Commun. 2015;6:7152. 
  • Berezin A, Zulli A, Kerrigan SW, Petrovic D, Kruzliak P. Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases.  Clin Biochem. 2015;48(9):562-8. 
  • Brown CE, McCarthy NS, Hughes AD, Sever P, Stalmach A, Mullen W, Dominiczak AF, Sattar N, Mischak H, Thom S, Mayet J, Stanton AV, Delles C. Urinary proteomic biomarkers to predict cardiovascular events. Proteomics Clin Appl. 2015;9(5-6):610-7. 
  • Bulik-Sullivan BK, et al [including Waddington JL]. Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015;47(3):291-5. 
  • Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba. Redox Biol. 2015 Dec;6:640-7.
  • Claro T, Kavanagh N, Foster TJ, O’Brien FJ, Kerrigan SW. Staphylococcus epidermidis serine-aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3. Microbes Infect. 2015 Jun;17(6):395-401. PMID: 25749709.
  • Connolly-Andersen AM, Sundberg E, Ahlm C, Hultdin J, Baudin M, Larsson J, Dunne E, Kenny D, Lindahl TL, Ramström S, Nilsson S. Increased thrombopoiesis and platelet activation in hantavirus infected patients. J Infect Dis. 2015;212(7):1061-9. 
  • Cowman J, Dunne E, Oglesby I, Byrne B, Ralph A, Voisin B, Mullers S, Ricco AJ, Kenny D. Age related changes are more profound in women than men.  Sci Rep. 2015;5:12235. 
  • Dempsey MA, Flood K, Burke N, Murray A, Cotter B, Mullers S, Dicker P, Fletcher P, Geary M, Kenny D, Malone FD. Platelet function in patients with a history of unexplained recurrent miscarriage who subsequently miscarry again. Eur J Obstet Gynecol Reprod Biol. 2015;188:61-5. 
  • Duffy FJ, O'Donovan D, Devocelle M, Moran N, O'Connell DJ, Shields DC. Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides. J Chem Inf Model. 2015;55(3):600-13. 
  • Fitzgibbon S, Cowman J, Ricco AJ, Kenny D, Shaqfeh ES.  Examining platelet adhesion via Stokes flow simulations and microfluidic experiments. Soft Matter. 2015;11(2):355-67. 
  • Gaul V, Lopez SG, Lentz BR, Moran N, Forster RJ, Keyes TE. The lateral diffusion and fibrinogen induced clustering of platelet integrin aIIbß3 reconstituted into physiologically mimetic GUVs. Integr Biol (Camb). 2015;7(4):402-11. 
  • Gresele P; Subcommittee on Platelet Physiology [including Kenny D]. Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH. J Thromb Haemost. 2015;13:314-22. 
  • Gusev A, et al [including Waddington JL]. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.  Am J Hum Genet. 2014;95(5):535-52.  
  • Harvey H, Piskareva O, Creevey L, Alcock LC, Buckley PG, O'Sullivan MJ, Segura MF, Gallego S, Stallings RL, Bray IM.  Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f.  Int J Cancer. 2015;136(7):1579-88. 
  • Hibar DP, et al [including Delanty N, Whelan C, Alhusaini S, Cavalleri GL]. Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 9;520(7546):224-9.
  • Hallast P, et al [Cavalleri GL]. The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.  Mol Biol Evol. 2015;32(3):661-73. 
  • Ikeda H, Adachi K, Fujita S, Tomiyama K, Saigusa T, Kobayashi M, Koshikawa N, Waddington JL. Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement. Behav Pharmacol. 2015;26(1-2):18-32. 
  • Jiang, L, O’Leary C, Kim, HA, Parish, CL, Massalas, J, Waddington, JL, Ehrlich, ME, Schutz, G, Gantois, I, Lawrence, A.J, Drago, J.  Motor and behavioural phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells.  Neurobiol Dis. 2015;76:137-58. 
  • Joshi PK, et al [including Stanton A].  Directional dominance on stature and cognition in diverse human populations. Nature. 2015;523(7561):459-62.  
  • Kapil V, Sobotka PA, Saxena M, Mathur A, Knight C, Dolan E, Stanton A, Lobo MD. Central iliac arteriovenous anastomosis for hypertension: targeting mechanical aspects of the circulation.  Curr Hypertens Rep. 2015;17(9):585. 
  • Kerrigan SW, Poole A. Focusing on the role of platelets in immune defence against invading pathogens.  Platelets. 2015;26(4):285. 
  • Kerrigan SW. The expanding field of platelet-bacterial interconnections. Platelets. 2015;26(4):293-301. 
  • Kerrigan SW, McDonnell C. Dysregulation of the endothelium during S. aureus infection. Biochem Soc Trans. 2015;43(4):715-719. 
  • Lobo MD, et al [including Stanton A]. Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial. Lancet. 2015;385(9978):1634-41. 
  • Locke AE et al [including Stanton AV]. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518(7538):197-206. 
  • Loh, PR. et al, [incl. Waddington J.L.]. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.  Nat Genet.  2015 Dec;47(12):1385-92. PMID: 26523775.
  • Lombardi F, Golla K, Fitzpatrick DJ, Casey FP, Moran N, Shields DC. Discovering anti-platelet drug combinations with an integrated model of activator-inhibitor relationships, activator-activator synergies and inhibitor-inhibitor synergies. PLoS Comput Biol. 2015;11(4):e1004119. 
  • Moriarty R, McManus CA, Lambert M, Tilley T, Devocelle M, Brennan M, Kerrigan SW, Cox D. A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function. Thromb Haemost. 2015 ;113(2):290-304. 
  • Nkiri N, Sardinha S, Nwosu B, McDonough CM, De Coteau PA, Duffy I, Waddington JL, Russell V.  Evaluation of knowledge and attitudes among primary care physicians in Cavan-Monaghan as 'gatekeepers-in-waiting' for the introduction of Carepath for Overcoming Psychosis Early (COPE). Early Interv Psychiatry. 2015;9(2):141-50. 
  • O'Connor A, Marsat JN, Mitrugno A, Flahive T, Moran N, Brayden D, Devocelle M. Poly(Ethylene glycol)-based backbones with high Peptide loading capacities. Molecules. 2014;19(11):17559-7.  
  • O'Donnell A, Moollan A, Baneham S, Ozgul M, Pabari RM, Cox D, Kirby BP, Ramtoola Z. Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide. J Pharm Pharmacol. 2015;67(4):525-36. 
  • O’Halloran JA, Dunne E, Gurwith MMP, Lambert JS, Sheehan GJ, Feeney ER, Pozniak A, Reiss P, Kenny D, Mallon PWG. The effect of initiation of antiretroviral therapy on monocyte, endothelial and platelet function in HIV-1 infection.  HIV Med. 2015;16(10):608-19.
  • O'Reilly JA, Fitzgerald J, Fitzgerald S, Kenny D, Kay EW, O'Kennedy R, Kijanka GS. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. PLoS One. 2015;10(4):e0123469. 
  • Pers TH, et al [including Stanton AV]. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun. 2015;6:5890. 
  • Pilson, Q, Jefferies, C A, Gabhann JN, Murphy CC. Isolation of microRNA from conjunctival impression cytology.  Exp Eye Res. 2015;132:109-14. 
  • Piskareva O, Harvey H, Nolan J, Conlon R, Alcock L, Buckley P, Dowling P, O'Sullivan F, Bray I, Stallings RL. The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro.  Cancer Lett. 2015;364(2):142-55. 
  • Prasad S, Katina S, Hennessy RJ, Murphy KC, Bowman AJ, Waddington JL. Craniofacial dysmorphology in 22q11.2 deletion syndrome by 3D laser surface imaging and geometric morphometrics: illuminating the developmental relationship to risk for psychosis. Am J Med Genet A. 2015;167A(3):529-36. 
  • Rodriguez-Alvarez N, Jimenez-Mateos EM, Dunleavy M, Waddington JL, Boylan GB, Henshall DC. Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice. Neurobiol Dis. 2015;83:100-114. 
  • Sukno FM, Waddington JL, Whelan PF. 3-D facial landmark localization with asymmetry patterns and shape regression from incomplete local features. IEEE Trans Cybern. 2015;45(9):1717-30.
  • Traynor C, Conlon P Jr, Phelan PJ, O'Kelly P, Elens L, McCormack M, Cavalleri G, Comber H, van Schaik RH, Conlon PJ. Association of CYP3A variants with kidney transplant outcomes. Ren Fail. 2015;37(4):562-6. 
  • Turner N, O’Mahony P, Hill M, Fanning F, Larkin C, Waddington J, O'Callaghan E, Clarke M. Work life after psychosis: a detailed examination. WORK. 2015;51(1):143-152. 
  • Vilhjálmsson BJ, Yang J, Finucane HK, Gusev A, Lindström S, Ripke S, Genovese G, Loh PR, Bhatia G, Do R, Hayeck T, Won HH; Schizophrenia Working Group of the Psychiatric Genomics Consortium, [incl. Waddington JL], Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study, et al. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores Am J Hum Genet. 2015 Oct 1;97(4):576-92.  
  • Whelan CD, Alhusaini S, O’Hanlon E, Cheung M, Iyer P, Meaney J, Fagan F, Boyle G, Delanty N, Doherty CP, Cavalleri, GL. White matter alterations in MRI-negative temporal lobe epilepsy patients and their asymptomatic siblings. Epilepsia.  2015;56(10):1551-61.

Reviews

  • O’Tuathaigh CM, Waddington JL.  Closing the translational gap between mutant mouse models and the clinical reality of psychotic illness. Neurosci Biobehav Rev. 2015;58:19-35

Book chapters

  • Waddington JL, O'Tuathaigh CMP. Modelling schizophrenia: strategies for identifying improved platforms for drug discovery. In: Lipina TV, Roder JC. (eds.). Drug Discovery for Schizophrenia. Washington, DC: Royal Society of Chemistry; 2015. 89-114.  

2014

  • Arman M, Krauel K, Tilley DO, Weber C, Cox D, Greinacher A, Kerrigan SW*, Watson SP*. Amplification of bacteria-induced platelet aggregation is triggered by FcgammaRIIa, integrin GPIIbIIIa and platelet factor 4. [*joint senior authors] Blood. 2014;123:3166-74.
  • Barron AJ, Hughes AD, Sharp A, Baksi AJ, Surendran P, Jabbour RJ, Stanton AV, Poulter N, Fitzgerald D, Sever P, O'Brien ET, Thom S, Mayet J. Long-term antihypertensive treatment fails to improve E/e' despite regression of LV mass. An ASCOT substudy. Hypertension. 2014;63:252-8.
  • Bryan K, Terrile M, Bray I, Domingo-Fernand´ez R, Watters R, Koster J, Versteeg R, and Stallings RL. Discovery and Visualization of miRNA-mRNA Functional Modules within Integrated Data using Bicluster Analysis. Nucleic Acids Res. 2014;42(3):e17.
  • Burke N, Flood K, Murray A, Cotter B, Dempsey M, Fay L, Dicker P, Geary M, Kenny D, Malone F. Platelet reactivity changes significantly throughout all trimesters of pregnancy compared with the nonpregnant state: a prospective study. BJOG. 2013;120(13):1599-604.
  • Burke N, Kenny D, Malone F. Platelet reactivity changes significantly throughout all trimesters of pregnancy compared with the nonpregnant state: a prospective study. BJOG. 2014;121(12):1580.
  • Cole AM, Petousi N, Cavalleri GL, Robbins PA.  Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.  High Alt Med Biol. 2014;15(4):497-9.  
  • Egan K, Cooke N, Dunne E, Murphy P, Quinn J, Kenny D. Platelet hyporeactivity in active myeloma. Thromb Res. 2014;134:747-9.
  • Egan K, Cooke N, Kenny D. Living in shear: platelets protect cancer cells from shear induced damage. Clin Exp Metastasis. 2014;31;697-704.
  • Fountoulakis KN et al [including Grady A, Waddington JL]. Relationship of suicide rates to economic variables in Europe: 2000-2011. Br J Psychiatry. 2014;205(6):486-96. 
  • Fudim M, Stanton A, Sobotka PA, Dolan E, Krum H. The thrill of success: central arterial-venous anastomosis for hypertension. Curr Hypertens Rep. 2014;16(12):497. 
  • Gresele P, Harrison P, Bury L, Falcinelli E, Gachet C, Hayward CP, Kenny D, Mezzano D, Mumford AD, Nugent D, Nurden AT, Orsini S, Cattaneo M. Diagnosis of suspected inherited platelet function disorders: results of a worldwide survey. J Thromb Haemost. 2014;12:1562-9.
  • Gómez-Herreros F, Schuurs-Hoeijmakers JHM, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, [including Cavalleri GL], et al.   TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function. Nat Genet. 2014;46:516-21.
  • International League Against Epilepsy Consortium on Complex Epilepsies [inc. Whelan C, Delanty N, McCormack M and Cavalleri G].  Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.  Lancet Neurol. 2014;13:893-903.
  • Kim HA, Jiang L, Madsen H, Parish CL, Massalas J, Smardencas A, O'Leary C, Gantois I, O'Tuathaigh C, Waddington JL, Ehrlich ME, Lawrence AJ, Drago J. Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells. Neurobiol Dis. 2014;62:323-37.
  • Lazzari E, Korczeniewska J, Ní Gabhann J, Smith S, Barnes BJ, Jefferies CA. TRIpartite Motif 21 (TRIM21) differentially regulates the stability of Interferon Regulatory Factor 5 (IRF5) isoforms. PLoS One. 2014;9:e103609.
  • Lazzari E., Jefferies CA. IRF5-mediated signaling and implications for SLE. Clin Immunol. 2014;153(2):343-352.
  • Lu YF, Goldstein DB, Angrist M, Cavalleri G. Personalized Medicine and Human Genetic Diversity. Cold Spring Harb Perspect Med. 2014;4(9).
  • McCarthy EM1, MacMullan PA, Al-Mudhaffer S, Madigan A, Donnelly S, McCarthy CJ, Molloy ES, Kenny D, McCarthy GM. Plasma fibrinogen along with patient-reported outcome measures enhances management of polymyalgia rheumatica: a prospective study. J Rheumatol. 2014;41:931-7.
  • McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D,O'Connell P, Kearns G, Ní Gabhann J, Jefferies CA. The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients. Rheumatology (Oxford). 2014;53:1586-94.
  • Mitrugno A, Williams D, Kerrigan S, Moran N. A novel and essential role for Fc?RIIa in cancer cell induced platelet activation. Blood. 2014;123:249-60.
  • Moran P, O'Tuathaigh CMP, Papaleo F, Waddington JL. Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models. Prog Brain Res. 2014;211:79-112.
  • Moriarty R, McManus CA, Lambert M, Tilley T, Devocelle M, Brennan M, Kerrigan SW, Cox D. A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function. Thromb Haemost. 2014;113(2).
  • Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Lemieux Perreault LP, [inc., Waddington JL], et al; International Schizophrenia Consortium; SGENE+ Consortium, O'Neill FA; Wellcome Trust Case Control Consortium 2, Kendler KS, Gill M, Riley BP, Spencer CC, Corvin A. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014; 23(12):3316-26.
  • Mullin AP, Gokhale A, Moreno-De-Luca A, Sanyal S, Waddington JL, Faundez V. Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes. Transl Psychiatry. 2013;3:e329.
  • Murphy D, Reddy E, Moran N, O'Neill S. Regulation of platelet activity in a changing redox environment. Antioxid Redox Signal. 2014; 20(13):2074-89.
  • Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan, K, Spence S, Kissenpfennig A, Johnston J, Fallon P and Jefferies C.A. Btk regulates macrophage polarization in response to lipopolysaccharide. PLoS One. 2014;9(1):e85834.
  • O'Callaghan MJ, Bay-Richter C, O'Tuathaigh CM, Heery DM, Waddington JL, Moran PM. Potentiation of latent inhibition by haloperidol and clozapine is attenuated in dopamine D2 receptor (Drd-2)-deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms? J Psychopharmacol. 2014;28(10):973-7.
  • O'Leary C, Desbonnet L, Clarke N, Petit E, Tighe O, Lai D, Harvey R, Waddington JL, O'Tuathaigh C. Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience. 2014;277:294-305.
  • Omer S, Kirkbride JB, Pringle DG, Russell V, O'Callaghan E, Waddington JL. Neighbourhood-level socio-environmental factors and incidence of first episode psychosis by place at onset in rural Ireland: The Cavan-Monaghan First Episode Psychosis Study [CAMFEPS]. Schizophr Res. 2014;152(1):152-7.
  • O'Tuathaigh CM, Desbonnet L, Waddington JL.Genetically modified mice related to schizophrenia and other psychoses: Seeking phenotypic insights into the pathobiology and treatment of negative symptoms. Eur Neuropsychopharmacol. 2014;24(5):800-21.
  • O'Tuathaigh CM, Gantois I, Waddington JL. Genetic dissection of the psychotomimetic effects of cannabinoid exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2014;52:33-40.
  • Planells-Ferrer L, Urresti J, Soriano A, Reix S, Murphy DM, Ferreres JC, Borràs F, Gallego S, Stallings RL, Moubarak RS, Segura MF, Comella JX. MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness. Cell Death Dis. 2014;5:e1401
  • Postmus I, Trompet S, Deshmukh HA, Barnes MR Li X Warren HR, Chasman DI, Zhou K, Arsenault BJ, et al [including Stanton A.] Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014;5:5068.
  • Rojas MA, Sukno FM, Waddington JL, Whelan PF. Quantitative comparison of hole filling methods for 3D object search. In: Fellner DW, Hansmann W, Purgathofer W, Sillion F. (eds.) Proceedings of the Eurographics Workshop on Object Retrieval, EG 3DOR 2014, Strasbourg, France. Goslar, Germany: Eurographics Association; 2014. p. 25-32.
  • Schizophrenia Working Group of the Psychiatric Genomics Consortium [inc. Waddington JL].  Biological insights from 108 schizophrenia-associated genetic loci. Nature.  2014;511(7510):421-7.  
  • Smith S, Ní Gabhann J, McCarthy E, Coffey B, Mahony R, Byrne JC, Stacey K, Ball E, Bell A, Molloy ES, Lee RZ, Kearns G, Harvey B and Jefferies CA. Estrogen receptor alpha regulates TRIM21 expression, contributing to dysregulated cytokine production in systemic lupus erythematosus. Arthritis Rheumatol. 2014;66(1):163-72.
  • Stavropoulos I, Golla K, Moran N, Martin F, Shields DC. Cadherin juxtamembrane region derived peptides inhibit TGFß1 induced gene expression. Bioarchitecture. 2014;4(3):103-10.
  • Walsh TG, Berndt MC, Carrim N, Cowman J, Kenny D, Metharom P. The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol. 2014;2:178-86.
  • Webster R, Patel A, Billot L, Cass A, Burch C, Neal B, Usherwood T, Thom S, Poulter N, Stanton A, et al, on behalf of the SPACE Collaboration. Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individuals at high cardiovascular risk - the SPACE Collaboration. Int J Cardiol. 2013;170(1):30-5.
  • Wood AR, et al [including Stanton AV]. Defining the role of common variation in the genomic and biological architecture of adult human height.  Nat Genet. 2014 Nov;46(11):1173-86. 
  • Zoungas S, et al [including Stanton AV]. Follow-up of blood-pressure lowering and glucose control in type 2 diabetes. N Engl J Med. 2014 Oct 9;371(15):1392-406. 

2013

Althoff K, Beckers A, Odersky A, Mestdagh P, Köster J, Bray IM, Bryan K, et al. [inc Stallings RL]  MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.    Int J Cancer. 2013;133:1064-73.

Alhusaini S, Ronan L, Scanlon C, Whelan CD, Doherty CP, Delanty N, Fitzsimons M. Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy.  Epilepsia. 2013;54:e138-41.

Bay-Richter C, O'Callaghan MJ, Mathur N, O'Tuathaigh CM, Heery DM, Fone KC, Waddington JL, Moran PM.  D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.   Neuropsychopharmacology. 2013;38:1512-20.

Byrne JC,  Ní Gabhann J,  Lazzari E, Mahony R, Smith R, Stacey K, Wynne C,  Jefferies CA.   Genetics of SLE - functional relevance for monocytes/macrophages in disease. Clin Dev Immunol. 2012;582352.

Byrne JC, Ní Gabhann J, Stacey K, Coffey BM , McCarthy E, Thomas W, and Jefferies  CA . Bruton's tyrosine kinase is required for apoptotic cell uptake via regulating the phosphorylation and localization of calreticulin. Journal of Immunology. J Immunol. 2013;190:5207-15.

Cattaneo M, Cerletti C, Harrision P, Hayward C, Kenny D, Nugent D, Nurden P, et al. Aggregometry: A consensus of the working party from the platelet physiology subcommittee of SSC/ISTH.  J Thromb Haemost.  2013;11:1183-9. 

Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien F, Kerrigan SW. Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and IL6 production. Microbiology. 2013;159:147-54. 

Cooke N, Egan K, McFadden S, Grogan L, Breathnach O, O'Leary J, Hennessy B, and Kenny D. Increased platelet reactivity in patients with late-stage metastatic cancer.  Cancer Med. 2013;2(4):564-70. 

Cox RF, Morgan MP. Microcalcifications in breast cancer: lessons from physiological mineralization. Bone. 2013;53:437-50.

Creevey L, Ryan R, Harvey H, Bray IM, Meehan M, Khan AR and Stallings RL.  MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1. Mol Cancer. 2013;12:23.

Cummings E, Donohoe G, Hargreaves A, Moore S, Fahey C, Dinan TG, McDonald C, O'Callaghan E, O'Neill FA, Waddington JL, Murphy KC, Morris DW, Gill M, Corvin A.  Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137.  Neurosci Lett. 2013;532:33-8.

Das S, Bryan K, Buckley PG, Piskareva O, Bray IM, Foley N, Ryan J. et al.  Neuroblastoma disease pathogenesis is modulated by epigenetically regulated MicroRNAs.  Oncogene. 2013;32:2927-36.

Domingo Fernandez R, Watters K, Piskareva O, Stallings RL and Bray I. Role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis. Pediatr Surg Int.  2013;29:101-119.

Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon C, Jimenez-Pacheco A, Moran C, Mesuret G, et al. CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.  Brain. 2013;136:577-92.

Fitzgerald S, Sheehan KM, O'Grady A, Kenny D, O'Kennedy R, Kay EW, Kijanka G. The relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients. J Gastroenterol Hepatol. 2013;28:967-74. 

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, [inc Stanton A].  Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet. 2013;22:1663-78.

Ilea G, Dana, Duffy C, Kavanagh L, Stanton A, Whelan P. Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery.   
IEEE Trans Ultrason Ferroelectr Freq Control.  2013;60:158-77.

Keane C, Petersen H, Tilley T, Haworth J, Cox D, Jenkinson HF, Kerrigan SW. Multiple sites on Streptococcus gordonii surface protein PadA binds to platelet GPIIbIIIa.    Thromb Haemost. 2013;110(6).

Kelleher E, Stanton A, Vale G, Smith D. Recurring Themes Arising During Medical Research Ethics Committee Review.  Ir Med J. 2013;106:184-5.

Kerrigan SW.  Platelet bacterial interactions in the pathogenesis of infective endocarditis. Part II: The Staphylococcus. In : Kerrigan SW (ed) Recent advances in Infective Endocarditis. InTech Publishers.  Chpt 3, pg34-52, ISBN 978-953-51-1169-6.   

Kinsella JA, Feeley TM, O'Neill D, Moore DJ, O'Neill SM,  Colgan MP,  Doherty CP, Murphy RP, Saqqur M, Moran N, et al.  Increased platelet counts and platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS). J Thromb Haemost. 2013;11:1407-16.

Lopez-Alonso A, Jose B, Sommers M, Foley DP, Ricco AJ.  Ramstrom S, Basabe-Desmonts L. Kenny D.  Individual platelet adhesion (iPA) assay: measuring platelet function and anti-platelet therapies in whole blood via digital quantification of cell adhesion.  Anal Chem. 2013;85:6497-504.

Lucitt MB, O'Brien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, Kent N, Ricco AJ, Kenny D. Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion. Anal Bioanal Chem. 2013;405:4823-34.

McCarthy EM, Lee RZ, Ni Gabhann J, Smith S, Cunnane G, Doran MF, Howard D, O'Connell P, Kearns G, Jefferies CA. Elevated B lymphocyte stimulator levels are associated with increased damage in an Irish systemic lupus erythematosus cohort. Rheumatology (Oxford).  2013;52:1279-84.

McCarthy EM, MacMullan PA, Al-Mudhaffer S, Madigan A, Donnelly S, McCarthy CJ, Molloy ES, Kenny D, McCarthy GM. Plasma fibrinogen is an accurate marker of disease activity in patients with polymyalgia rheumatia. Rheumatology (Oxford). 2013.52;465-71. 

McCarthy EM, Ní Gabhann J, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D, O'Connell P, Kearns G, Jefferies CA. The association of cytokines with disease activity and damage accrual in Systemic Lupus Erythematosus patients.  Rheumatology (Oxford). 2013;52:1279-84.

McGivern TJP, Molloy K, Baher M, McElvaney G, Moran N, Kerrigan SW. A platelet dense-granule secretion defect may lead to a muted inflammatory cell mobilization response in Cystic Fibrosis patients. J Thromb Haemost. 2013;11:1939-42.

Miller-Delaney SF, Das S, Stallings RL, Henshall DC.  Investigating gene promoter methylation in a mouse model of status epilepticus. Methods Mol Biol. 2013;1067:87-101.

O'Tuathaigh CM, Moran PM, Waddington JL. Genetic models of schizophrenia and related psychotic disorders: progress and pitfalls across the methodological 'minefield'. Cell Tissue Res. 2013;354:247-57.   

Owoeye O, Kingston T, Scully PJ, Baldwin P, Browne D, Kinsella A, Russell V, O'Callaghan E, Waddington JL. Epidemiological and clinical characterisation following a first psychotic episode in major depressive disorder: comparisons with schizophrenia and bipolar disorder.   Schizophr Bull. 2013;39:756-65.

Parker JP, Nimir H, Griffith DM, Duff B, Chubb AJ, Brennan MP, Morgan MP, Egan DA, Marmion CJ.  A novel platinum complex of the histone deacetylase inhibitor belinostat: Rational design, development and in vitro cytotoxicity. J Inorg Biochem. 2013;124: 70- 77.

Shanley DK, Kiely PA, Golla K, Allen S, Martin K, O'Riordan RT, Ball M, Aplin JD, Singer BB, Caplice N, Moran N, Moore T. Pregnancy-specific glycoproteins bind integrin aIIbß3 and inhibit the platel-fibrinogen interaction. PLoS One. 2013;8:e57491.  

Spence S, Fitzsimons A, Boyd CR, Kessler J, Fitzgerald D, Elliott J, Ní Gabhann J,  Smith S, Sica A, Hams E, Saunders SP, Jefferies CA, Fallon PG, McAuley DF, Kissenpfennig A, and Johnston JA.  Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.  Immunity. 2013;38:66-78.

Sridhar S, Al-Moallem B, Kamal H, Terrile M, and Stallings RL. New Insights into the genetics of neuroblastoma: implications for diagnosis and therapy. Mol Diagn Ther. 2013;17:63-69.

The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Authors/Task Force Members, Mancia G. ESH/ESC Guidelines for the management of arterial hypertension.      Eur Heart J. 2013;34(28):2159-219.

Tilley DO, Albert MA, Smolenski A, Cox D, O'Donnell JS, Douglas CWI, Watson SP, Kerrigan SW. Glycoprotein Ibalpha and FcgammaRIIa play key roles in platelet activation by the colonizin bacterium Streptococcus oralis.    J Thromb Haemost. 2013;11:941-50.

Tomiyama K, Kato R, Hara Y, Kobayashi M, Mishina M, Yanagawa Y, Kinsella A, Koshikawa N, Waddington JL. Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: Glutamate N2A/B/D [GluRe1/2/4] subtypes and the GABA synthesizing enzyme GAD65.  Neuroscience. 2013;250:743-54.

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng YC, [inc. Stanton A], International Stroke Genetics Consortium.    Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke.   Stroke. 2013;44:2703-9.

Waddington JL, Buckley PF. Psychotic depression: an under-appreciated window to explore the dimensionality and pathobiology of psychosis. Schizophr Bull. 2013;39:754-5.

Watters KM, Bryan K, Foley NH, Meehan M. and Stallings RL.  Expressional alterations in functional ultra-conserved non-coding rnas in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells.  BMC Cancer. 2013;13:184.

Wooley R, Prendergast Ú, Jose B, Kenny D, McDonagh C.  A rapid topographical platelet activation assay.  Analyst. 2013;138:4512-18

Woolley R, Roy S, Prendergast Ú, Basabe-Desmont L, Kenny D, McDonagh C.  From particle to platelet: optimization of a stable, high brightness fluorescent nanoparticle based cell detection platform. Nanomedicine. 2013;9:540-9.

Webster R, Patel A, Billot L, Cass A, Burch C, Neal B, Usherwood T, inc.  Stanton A, on behalf of the SPACE Collaboration.  Prospective meta-analysis of trials comparing fixed dose combination based care with usual care in individuals at high cardiovascular risk - the SPACE Collaboration.    Int J Cardiol. 2013;170:30-5.


2012

Adachi K, Kobayashi M, Kawasaki T, Yokoyama C, Waddington JL, Sakagami H, Onoe H, Koshikawa N. Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease. J Neural Transm 2012;119:933-41.  

Alhusain S, Doherty CP, Scanlon C, Ronan L, Maguire S, Borgulya G, Brennan P, Delanty N, Fitzsimons M, Cavalleri GL. A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis. Epilepsy Res 2012;99:156-66.

Alhusaini S, Doherty CP, Palaniyappan L, Scanlon C, Maguire S, Brennan P, Delanty N, Fitzsimons M, Cavalleri GL. Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia  2012 53:995-1003.

Arthur JF, Qiao J, Shen Y, Davis AK, Dunne E, Berndt MC, Gardiner EE, Andrews RK. Itam receptor-mediated generation of reactive oxygen species in human platelets occurs via syk-dependent and -independent pathways. J Thromb Haemost 2012;10:1133-1141.

Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, [inc Stanton A].  Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.   Am J Hum Genet 2012;91:823-38.

Behan AT, Hryniewiecka M, O'Tuathaigh CMP, Kinsella A, Cannon M, Karayiorgou M, Gogos JA, Waddington JL, Cotter DR. Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways. Neuropsychopharmacology 2012;37:1773-83 .

Cox R, Jenkinson A, Pohl K, O'Brien F, Morgan M. Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment. PLoS ONE 2012;7:e41679.

Cox RF, Hernandez-Santana A, Ramdass S, McMahon G, Harmey JH, Morgan MP. Microcalcifications in breast cancer: novel insights into the molecular mechanism and functional consequence of mammary mineralisation.   Br J Cancer 2012;106:525-37.  

Decock A, Ongenaert M, De Preter K, Hoebeeck J, Van Peer G, Van Criekinge W, Ladenstein R, Schulte JH, Noguera R, Stallings RL, et al. Genome-wide promoter methylation analysis in neuroblastoma identifies methylation biomarkers with prognostic power.   Genome Biol 2012;13:R95

Desbonnet L, O'Tuathaigh CMP, Waddington JL. Modelling schizophrenia: uncovering novel therapeutic targets.  Expert Rev Clin Pharmacol. 2012;5:667-76

Desbonnet L, Tighe O, Karayiorgou M, Gogos JA, Waddington JL. O'Tuathaigh CM. Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice. Behav Brain Res 2012;228:351-358.

Desbonnet L, O'Tuathaigh C, Clarke G, O'Leary C, Petit E, Clarke N, Tighe O, Lai D, Harvey N, Cryan JF, Dinan TG, Waddington JL. Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction. Brain Behav Immun 2012;26:660-71.

Dunne E, Spring CM, Reheman A, Jin W, Berndt MC, Newman DK, Newman PJ, Ni H, Kenny D.   Cadherin 6 has a functional role in platelet aggregation and thrombus formation.  ATVB 2012;32:1724-1731.

Fieuw A, Kumps C, Schramm A, Pattyn F, Menten B, Antonacci F, Sudmant P, et al [including Stallings RL.]. Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas. Int J Cancer 2012;130:2599-606. 

Heinzen EL, Depondt C, Cavalleri GL, Ruzzo EK, Walley NM, Need AC., et al. Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.  Am J Hum Genet. 2012 10;91:293-302.

Hill M, Crumlish N, Whitty P, Clarke M, Browne S, Gervin M, Kinsella A, Waddington JL, Larkin C, O'Callaghan E. The relationship between insight and neurological dysfunction in first-episode psychosis. Eur Psychiatry 2012;27:200-5.

Hill M, Crumlish N, Whitty P, Clarke M, Browne S, Gervin M, Macklin E, Kinsella A, Larkin C, Waddington JL, O'Callaghan E. Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. Schizophr Res 2012;141:215-21.

Howley R, Kinsella P, Buckley PG, Alcock L, Jansen M, Heffernan J, Stallings RL, Brett FM, Amberger-Murphy V,  Farrell MA.  Comparative genomic and proteomic analysis of High Grade Glioma primary cultures and matched tumour in situ. Exp. Cell Res 2012;318:2245-2256. 

Irish Schizophrenia Genomics Consortium [including Waddington JL] and the Wellcome Trust Case Control Consortium 2. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.  Biol Psychiatry 2012;72:620-628. 

Lombardi F, De Chaumont C, Shields DC, Moran N. Platelet signalling networks: pathway perturbation demonstrates differential sensitivity of ADP secretion and fibrinogen binding. Platelets 2012;23:17-25. 

Lynch J, Fay J, Meehan M, Bryan K, Watters KM, Murphy DM, Stallings RL. MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-B signalling pathway. Carcinogenesis 2012;33:976-85.

MacMullan PA, McCarthy GM. Treatment and management of pseudogout; insights for the clinician. Ther Adv Musculoskelet Dis 2012;4:121-31.

MacMullan PA. Guilty by association: platelet reactivity and inflammation in psoriatic arthritis. J Rheumatol 2012;39:210-1.

McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, er al [including Cavalleri G.]. Genome-wide mapping for clinically relevant predictors of lamotrigine and phenytoin-induced hypersensitivity reactions.  Pharmacogenomics 2012;13:399-405. 

McKiernan RC, Jimenez-Mateos EM, Sano T, Bray I,  Stallings RL,  Meller R, Simon RP,  and Henshall DC.  Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Experimental Neurology 2012;237:346-54. 

McKiernan R, Jimenez-Mateos Eva M, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O'Brien D, Meller R, Simon RP, Stallings RL, Henshall DC.  Reduced Mature MicroRNA Levels in Association with Dicer Loss in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis. 2012;7(5):e35921.

Meehan M,  Parthasarathi L,   Moran N,   Jefferies CA,  Foley N,  Lazzari E,   Murphy D,  Ryan J, Ortiz B,  Fabius A W M,  Chan TA, Stallings RL.   Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene.  Molecular Cancer 2012; 11:6.

Miller-Delaney S, Das S, Sano T, Bryan K, Buckley P, Stallings RL and Henshall D (2012) Differential DNA methylation patterns define status epilepticus and epileptic tolerance. J Neurosci 2012;32:1577-1588.

Ní Gabhann J, Spence S, Wynne C, Smith SA, Byrne JC, Coffey B, Stacey K, Kissenpfennig A, Johnston JA, Jefferies CA. Defects in acute responses to TLR4 in Btk-deficient mice results in impaired dendritic cell-induced IFN-? production by Natural Killer cells. Clin Immunol 2012;142:373-82.

O'Brien S, Kent NJ, Lucitt M, Ricco AJ, McAtamney C, Kenny D, Meade G. Effective Hydrodynamic Shaping of Sample Streams in a Microfluidic Parallel-Plate Flow-Assay Device: Matching Whole Blood Dynamic Viscosity.  IEEE Trans Biomed Eng 2012;59:374-82.

O'Tuathaigh CM, Clarke G, Walsh J, Desbonnet L, Petit E, O'Leary C, Tighe O, Clarke N, Karayiorgou M, Gogos JA, Dinan TG, Cryan JF, Waddington JL. Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes. Int J Neuropsychopharmacol. 2012;15:1331-42.

O'Tuathaigh CM, Desbonnet L, Moran PM, Waddington JL. Susceptibility genes for schizophrenia: mutant models, endophenotypes and psychobiology. Curr Top Behav Neurosci 2012;12:209-50.

O'Tuathaigh CM, Desbonnet L, Lee P, Waddington JL. Catechol-O-methyltransferase as a drug target for schizophrenia. CNS & Neurol Disord Drug Targets 2012;11:282-91.

Ronan L, Alhusaini S, Scanlon C, Doherty CP, Delanty N, Fitzsimons M. Widespread cortical morphologic changes in juvenile myoclonic epilepsy: evidence from structural MRI. Epilepsia 2012;53:651-658.

Ryan J, Tivnan A, Fay J, Bryan K, Meehan M, Creevey L, Lynch J, Bray IM,  O'Meara A, Davidoff AD and Stallings RL. MicroRNA-204 increases sensitivity of neuroblastoma cells to cisplatin and is associated with a favourable clinical outcome. Br J Cancer 2012;107:967-76.

Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, Arima H,  et al [including Stanton AV.]. Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase. Hypertension 2012;59:248-55.

Slattery MM, Foley C, Kenny D, Costello RW, Logan PM, Lee MJ.  Long-term follow-up of non-calcified pulmonary nodules (<10 mm) identified during low-dose CT screening for lung cancer. Eur Radiol. 2012;22:1923-8.

Smith S, Ni Gabhann J, Higgs R, Stacey K, Wahren-Herlenius M, Espinosa A, Totaro MG, et al [including Jefferies CA]. Enhanced interferon regulatory factor 3 binding to the IL-23p19 promoter correlates with enhanced IL-23 expression in systemic lupus erythematosus. Arthritis Rheum 2012;64:1601-9.

Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann O, Bernard M, Brown AA, Cannon DM,[ including  Cavalleri GL].   Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet 2012;44:552-561.

Tivnan A, Orr WS, Gubala V, Nooney R, David E. Williams DE, McDonagh C, Prenter S, Harvey H, Domingo-Ferna´ndez R, Bray IM, Piskareva O, Ng CY, Lode HN, Davidoff AM, Stallings RL. Inhibition of Neuroblastoma Tumor Growth by TargetedDelivery of MicroRNA-34a Using Anti-Disialoganglioside GD2 Coated Nanoparticles.PLoS One 2012;7(5):e38129.

Tomiyama K, Drago J, Waddington JL, Koshikawa N. Constitutive and conditional mutant mouse models for understanding dopaminergic regulation of orofacial movements: emerging insights and challenges. J Pharmacol Sci. 2012; 119:297-301.

van der Werf M, Hanssen M, Köhler S, Verkaaik M, Verhey FR; RISE Investigators [including Baldwin P & Waddington JL], van Winkel R, van Os J, Allardyce J.  Systematic review and collaborative recalculation of 133 693 incident cases of schizophrenia.  Psychol Med 2012;17:1-8. 

Vangjeli C, Dicker P, Tregouet D-A, Shields D, Evans A, Stanton AV. A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: The MORGAM project. JRAAS 2011;12:504-9.

Waddington JL, Hennessy RJ, O'Tuathaigh CMP, Owoeye O, Russell V. Schizophrenia and the lifetime trajectory of psychotic illness: developmental neuroscience and pathobiology, redux. In: The Origins of Schizophrenia (A.S. Brown & P.H. Harrison, Eds), Columbia University Press, New York. 2012; pp 3-21.

Walsh J, Desbonnet L, Clarke N, Waddington JL, O'Tuathaigh CMP.  Disruption of exploratory and habituation behavior in mice with mutation of DISC1: an ethologically based analysis. J Neurocsi Res 2012;90:1445-53.  

Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW. Multiple signals induced by Staphylococcus aureus Protein A results in bone loss and bone destruction. PLoS ONE  2012;7:e40586.


2011

ADVANCE Echocardiography Substudy Investigators and the ADVANCE Collaborative Group. [including A Stanton].  Effects of perindopril-indapamide on left ventricular diastolic function and mass in patients with type 2 diabetes: the ADVANCE Echocardiography Substudy. J Hypertens 2011;29:1439-47.

 

Arthur JF, Shen Y, Gardiner EE, Coleman L, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost 2011;9:163-72.

Basabe-Desmonts L, Meade G, Kenny D. New trends in bioanalytical microdevices to assess platelet function. Expert Rev Mol Diagn 2011;10:869-74.

Buckley PG, Alcock L, Heffernan J, Woods J, Brett F, Stallings RL, Farrell MA. Loss of chromosome 1p/19q in oligodendroglial tumors: refinement of chromosomal critical regions and evaluation of internexin immunostaining as a surrogate marker. J Neuropathol Exp Neurol 2011;70:177-82.

Boutouyrie P, Lacolley P, Briet M, Regnault V, Stanton A, Laurent S, Mahmud A. Pharmacological modulation of arterial stiffness. Drugs 2011;71:1689-701.

Catarino CB, Kasperaviciute D, Thom M, Cavalleri GL, Martinian L, Heinzen EL, Dorn T, Grunwald T, Chaila E, Depondt C, Krämer G, Delanty N, Goldstein DB, Sisodiya SM. Genomic microdeletions associated with epilepsy: Not a contraindication to resective surgery. Epilepsia 2011;52:1388-92.

Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW. Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis. PLoS ONE. 2011;6(4):e18748.

Corrigan L, Jefferies C, Lee TC, Daly J. Evaluation and optimization of IgY Spin Column technology in the depletion of abundant proteins from human serum. Proteomics. 2011;11:3415-9.

Cox D, Kerrigan SW, Watson SP. Platelets and the innate immune system: Mechanisms of bacterial induced platelet activation. J Thromb Haemost. 2011;9:1097-107.

Egan K, Crowley D, Smyth P, O'Toole S, Spillane C, Martin C,  Gallagher M, et al [inc. Kenny D. ].  Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells. PLoS ONE 2011;6:e26125.

Gangarossa G, Di Benedetto M, O'Sullivan GJ, Dunleavy M, Alcacer C, Bonito-Oliva A, Henshall DC, Waddington JL, Valjent E, Fisone G. Convulsant doses of a dopamine d1 receptor agonist result in erk-dependent increases in zif268 and arc/arg3.1 expression in mouse dentate gyrus. PLoS One 2011;6(5):e19415.

Griffith DM, Duff B, Suponitsky KY, Kavanagh K, Morgan MP, Egan D, Marmion CJ. Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity. J Inorg Biochem 2011;105:793-9.

Hernandez-Santana A, Yavorskyy A, Loughran ST, McCarthy GM, McMahon GP. New approaches in the detection of calcium-containing microcrystals in synovial fluid. Bioanalysis 2011;3:1085-91.

Hickey J, Lynch I, Dawson K, Cox D, Keenan A. Simultaneous release of a hydroxy-methylglutaryl coenzyme: A reductase inhibitor and a glycoprotein IIb/IIIa antagonist from a thermoresponsive NiPAAm/NtBAAm copolymer system. Biomat Nanobiotechnol 2011;2:18-27.

Jefferies C, Wynne C, Higgs R. Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? Nat Rev Immunol 2011;11:617-625.

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, et al; [including Stanton AV]. Blood pressure loci identified with a gene-centric array. Am J Hum Genet 2011;89:688-700.  

Kas, MJ, Kahn RS, Collier DA, Waddington JL, Ekelund J, Porteous DJ, Schughart K. & Hovatta I. Translational neuroscience of schizophrenia: seeking a meeting of minds between mouse and man. Science Transl Med 2011; 3:102mr3. 

Kelly C, Jefferies C, Cryan SA. Targeted liposomal drug delivery to monocytes and macrophages. J Drug Deliv 2011;2011:727241.

Kent NJ, O'Brien S, Basabe-Desmonts L, Meade GR, Maccraith BD, Corcoran BG, Kenny D, Ricco AJ. Shear-mediated platelet adhesion analysis in less than 100 µl of blood: toward a POC platelet diagnostic. IEEE Trans Biomed Eng 2011;58;826-30.

Kerrigan SW, Cox D. Biological mechanisms: Platelets and bacteria - current scientific evidence and methods of analyses. In: LL. Haheim (ed) Oral Infections and Cardiovascular Disease. Betham Science Publishers 2011;Chpt 6, pg 41-61.

Khamis RY, Johns M, Thom S, Mayet J, McConnell E, Stanton A, Jeyapalan S, Annon S, Wrigley S, Hughes A, Haskard DO.  IgG anti-malonedialdehyde-LDL antibodies are associated with low risk of cardiovascular events in a substudy of the anglo-scandinavian cardiac outcomes trial (Ascot), and are unrelated To LDL, CRP levels and statin treatment. Heart 2011;97:e7.

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, et al [inc. Stanton A]. Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height. Am J Hum Genet 2011;7;88:6-18.

McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, Carrington M, Sills GJ, et al [incl. Cavalleri GL]. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011;364:1134-43.

McGarrigle SA, O'Neill S, Walsh GM, Moran N, Graham IM, Cooney MT, Monavari A, Mayne P, Collins P. Integrin a(IIb)ß3 exists in an activated state in subjects with elevated plasma homocysteine levels. Platelets 2011;22:63-71.

MacMullan PA, McMahon, G, McCarthy GM. Basic calcium phosphate crystals in osteoarthrits. Joint Bone Spine 2011;78:358-63.

MacMullan PA, McMahon G, McCarthy G. Detection of basic calcium phosphate crystals in osteoarthritis Purchase the full-text article. Joint Bone Spine 2011;78:358-63.

Mylotte D, Peace A, Tedesco T, Mangiacapra F, Dicker P, Kenny D, Foley D.
Clopidogrel discontinuation and platelet reactivity following coronary stenting.
J Thromb Haemost 2011;9:24-32.

Mylotte D, Foley D, Kenny D. Platelet function testing: methods of assessment and clinical utility. Cardiovasc Hematol Agents Med Chem 2011;9:14-24.

Murphy DM, Buckley PG, Das S, Watters KM, Bryan K, Stallings RL. Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeECP2 at genomic sites in neuroblastoma. PLoS ONE 2011;6:e21436.

Ní Gabhann J, Jefferies CA. TLR-induced activation of Btk - Role for endosomal MHC class II molecules revealed. Cell Res 2011;21:998-1001.

O'Tuathaigh CM, Desbonnet L, Moran PM, Kirby BP, Waddington JL. Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges. Curr Top Behav Neurosci 2011;7:87-119.

Ramtoola Z, Lyons P, Keohane K, Kerrigan SW, Kirby B, Kelly JG. Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets. J Pharm Pharmacol 2011;63:26-32.

Runker AE, O'Tuathaight C, Dunleavy M, Morris DW, Little GE, Corvin AP, Gill M, Henshall DC, Waddington JL, Mitchell KJ.   Mutation of Semaphorin-6A Disrupts Limbic and cortiacal connectivity and models neurodevelopmental psychopathology. PloS One 2011;6:e26488.

Satchell C, O'Halloran J, Cotter A, Peace A, O'Connor E, Tedesco A, Feeney E, Lambert J, Sheehan G, Kenny D, Mallon P. Increased platelet reactivity in HIV-1-infected patients receiving abacavir-containing antiretroviral therapy. J Infect Dis 2011;204:1202-10.

Smith EJ, Visai L, Kerrigan SW, Speziale P Foster TJ. The Sbi protein: a multifunctional immune evasion factor of Staphylococcus aureus. Infect Immun 2011;79:3801-9.

Stallings RL, Foley NH, Bray IM, Das S, Buckley PG. MicroRNA and DNA methylation alterations mediating retinoic acid induced neuroblastoma cell differentiation.Semin Cancer Biol 2011;21:283-90.

Starmans-Kool MJ, Stanton AV, Xu YY, McG Thom SA, Parker KH, Hughes AD.
High dietary salt intake increases carotid blood pressure and wave reflection in normotensive healthy young men. J Appl Physiol 2011;110:468-71.

Terrile M, Bryan K, Vaughan L, Hallsworth A, Webber H, Chesler L, Stallings RL. miRNA expression profiling of the murine TH-MYCN neuroblastoma model reveals similarities with human tumors and identifies novel candidate MiRNAs. PLoS ONE 2011; 6:e28356.

Tomiyama K, Kim H, Kinsella A, Ehrlich ME, Schütz G, Koshikawa N, Lawrence AJ, Waddington JL, and Drago J. Phenotypic disruption to orofacial movement topography in conditional mutants with generalised CamKIIa/Cre D1Tox vs striatal-specific DARPP-32/Cre D1Tox ablation of D1 dopamine receptor-expressing cells. Synapse 2011;65:835-42.

Tomiyama K, O'Tuathaigh CMP, Waddington JL. Regulation of orofacial movement: amino acid mechanisms and mutant models. Int Rev Neurobiol 2011;97:61-75.

Tivnan A, Tracey L, Buckley PG, Alcock LC, Davidoff AM, Stallings RL.
MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma.
BMC Cancer 2011;11:33.

Vangjeli C, Dicker P, Tregouet D-A, Shields D, Evans A, Stanton AV. A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: The MORGAM project. JRAAS J Renin Angiotensin Aldosterone Syst. 2011;12:504-9.

Waddington JL, O'Sullivan GJ, Tomiyama K. Regulation of orofacial movement: dopamine receptor mechanisms and mutant models. Int Rev Neurobiol 2011;97:39-60.

Waddington, J.L, O'Tuathaigh, C.M. & Remington, G.J. Second-generation antipsychotic drugs: mechanistically distinct or minor variants? In: Therapeutic Strategies in Schizophrenia (A. Mortimer, A & P. McKenna, Eds), Clinical Publishing, Oxford 2011; 207-216. 

2010

Babovic D, Jiang L, Gantois I, Lawrence AJ, Ferreri V, Schutz G, Waddington JL, Drago J. Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells. Behav Brain Res 2010;206:78-87.

Basabe-Desmonts L, Meade G, Kenny D. New trends in bioanalytical microdevices to assess platelet function. Expert Rev Mo Diagn 2010;10:869-874.

Basabe-Desmonts,L, Ramstrom S, Meade G, O'Neill S, Riaz A, Lee L, Ricco AJ, Kenny D. Single-step separation of platelets from whole blood coupled with digital quantification by interfacial platelet cytometry. Langmuir 2010;26:14700-6.

Cox D, Brennan M, Moran N. Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov 2010;9:804-20.

Cummings E, Donohoe G, McDonald C, Dinan TG, O'Neill FA, O'Callaghan E, Waddington JL, Murphy KC, Gill M, Morris DW, Corvin A. Clinical symptomatology and the psychosis risk gene ZNF804A. Schizophr Res. 2010;122:273-5.

Desbonnet L, Tomiyama K, Koshikawa N, O'Tuathaigh CM. & Waddington JL. Mutant and transgenic tools in modelling schizophrenia. In: Transgenic and Mutant Tools to Model Brain Disorders (A.V. Kalueff, Ed), Humana Press, Totawa, NJ 2010; pp 217-239. 

Flood K, Peace A, Kent E, Tedesco T, Dicker P, Geary M, Malone FD, Kenny D. Platelet reactivity and pregnancy loss. Am J Obstet Gynecol 2010;203:281 e1-5.

Fujita S, Kiguchi M, Kobayashi M, Koshikawa N, Waddington JL. Involvement of NMDA receptors in the ventrolateral striatum of rats in apomorphine-induced jaw movements. Brain Res 2010;1322:30-7.

Fujita S, Kiguchi M, Kobayashi M, Kinsella A, Koshikawa N, Waddington JL. Assessment of jaw movements by magnetic sensor in relation to topographies of orofacial behaviour in freely moving rats: Studies with the dopamine D(1)-like receptor agonists SKF 83822 vs SKF 83959. Eur J Pharmacol 2010;632:39-44.

Hennessy RJ, Baldwin PA, Browne DJ, Kinsella A, Waddington JL. Frontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia. Schizophr Res 2010;122:63-71.

Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperaviciute? D, Tate SK, Caboclo LO, Sander JW, Clayton L, Linney KN, Shianna KV, Gumbs CE, Smith J, Cronin KD, Maia JM, Doherty CP, Pandolfo M, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Kälviäinen R, Eriksson K, Kantanen AM, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Wieser HG, Zumsteg D, Ortega M, Wood NW, Huxley-Jones J, Mikati M, Gallentine WB, Husain AM, Buckley PG, Stallings RL, Podgoreanu MV, Delanty N, Sisodiya SM, Goldstein DB. Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet 2010;86:707-18.

Higgs R, Lazzari E, Wynne C, Ní Gabhann J, Espinosa A, Wahren-Herlenius M, Jefferies CA. Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors. PLoS One. 2010;5:e11776.

Hill M, Crumlish N, Whitty P, Clarke M, Browne S, Kamali M, Kinsella A, Waddington JL, Larkin C, O'Callaghan E. Nonadherence to medication four years after a first episode of psychosis and associated risk factors. Psychiatr Serv 2010; 61:189-92.

Kasperaviciute D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LM, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser HG, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen AM, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain 2010;133:2136-47.

Keane C, Tilley T, Cunningham A, Smolenski A, Kadioglu A, Cox D, Jenkinson HF, Kerrigan SW. Invasive Streptococcus pneumoniae triggers platelet activation via toll like receptor 2. J Thromb Haemost 2010; 8:2757-2765.

Keane C, Petersen H, Reynolds K, Newman DK, Cox D, Jenkinson HF, Newman PJ, Kerrigan SW. Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing bacterium, Streptococcus gordonii. Arterioscler Thromb Vasc Biol. 2010;30:2408-15.

Kelly BD, O'Callaghan E, Waddington JL, Feeney L, Browne S, Scully PJ, Clarke M, Quinn, JF, McTigue O, Morgan MG, Kinsella A, Larkin C. Schizophrenia and the city: A review of literature and prospective study of psychosis and urbanicity in Ireland. Schizophr Res 2010;116:75-89.

Kerrigan SW, Cox D. Platelet-bacterial interactions. Cell Mol Life Sci 2010;67:513-23.

Kerrigan SW, Cox D. The effect of bacterial toxins on platelet function. In: RM. Kini, Clemtson, FS. Markland, MA McLane, T. Morita (eds) Toxins and haemostasis: from bench to bedside. Springer Science Science-Verlag GmBH. 2010; Chpt 36, pg 637- 651.

Kirby B, Waddington JL, O'Tuathaigh CMP. Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption. Brain Res Bull2010; 83:162-176.

Kijanka G, Kay EW, Murray F, Cummins R, MacCraith B, Murphy D, Prehn JHM, Kenny D. Screening high density protein arrays reveals novel antibody signature in colorectal cancer. Gut 2010;59:69-78.

Lincoln B, Ricco AJ, Kent NJ, Basabe-Desmonts L, Lee LP, MacCraith BD, Kenny D, Meade GR. Integrated system investigating shear-mediated platelet interactions with von Willebrand Factor using microliters of whole-blood. Anal Biochem 2010; 405:174-83.

Mallon C, de Chaumont C, Moran N, Forster RJ, Keyes TE. Electrochemical desorption of fibrinogen from gold. Langmuir 2010;26:293-8.

Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald DJ. G-protein b3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial. J Thromb Haemost 2010;8:934-41.

MacMullan PA, McCarthy GM. The meniscus, calcification and osteoarthritis:a pathologic team. Arthritis Res Ther 2010;12:116.

MacMullan PA, Peace AJ, Madigan AM, Tedesco AF, Kenny D, McCarthy GM. Platelet hyper-reactivity in active inflammatory arthritis is unique to the ADP pathway: a novel finding and potential therapeutic target. Rheumatology 2010;49:240-5.

Miajlovic H, Zapotoczna M, Geoghegan JA, Kerrigan SW, Speziale P, Foster TJ.
Direct interaction of iron regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets. Microbiology 2010;156:920-28.

Ní Gabhann J, Higgs R, Brennan K, Thomas W, Damen JE, Ben Larbi N, Krystal G, Jefferies CA. Absence of SHIP-1 results in constitutive phosphorylation of TBK1 and enhanced TLR3-dependent IFN-b production. J Immunol 2010;184;2314-20.

O'Dushlaine CT, Morris D, Moskvina V, Kirov G, Consortium IS, Gill M, Corvin A, Wilson JF, Cavalleri GL. Population structure and genome-wide patterns of variation in Ireland and Britain. Eur J Hum Genet 2010;1-7.

Omer S, Behan C, Waddington JL, O'Callaghan E. Early intervention in pssychosis: service models worldwide and the Irish experience. Ir J Psychol Med 2010;27:210-214.

O'Sullivan GJ, O'Tuathaigh CM, Tomiyama K, Koshikawa A, Waddington JL. Dopamine receptors and behavior: from psychopharmacology to mutant models. In: The Dopamine Receptors (K. Neve, Ed), Humana Press, Totawa, NJ 2010; pp 323-371.

O'Tuathaigh CMP, Harte M, O'Leary C, O'Sullivan GJ, Blau C, Lai D, Harvey RP, Tighe O, Fagan AJ, Kerskens C, Reynolds GP, Waddington JL. Schizophrenia-related endophenotypes in heterozygous neuregulin-1 ‘knockout' mice. Eur J Neurosci 2010 ;31:349-58.

O'Tuathaigh C, Hryniewiecka M, Behan A, Tighe O, Coughlan C, Desbonnet L, Cannon M, Karayiorgou M, Gogos JA, Cotter DR, Waddington JL. Chronic adolescent exposure to D-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes. Neuropsychopharm 2010;35:2262-2273.

O'Tuathaigh CM, Waddington JL. Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia. Schizophr Bull 2010;36:243-5.

O'Tuathaigh CM, Kirby BP, Moran PM, Waddington JL. Mutant mouse mdels: genotype-phenotype relationships to negative symptoms in schizophrenia. Schizophr Bull 2010;36:271-88.

Owoeye O, Kingston T, Hennessy RJ, Baldwin PA, Browne D, Scully PJ, Kinsella A, Russell V, O'Callaghan E. & Waddington JL. The ‘totality' of psychosis: epidemiology and developmental pathobiology. In: Search for the Causes of Schizophrenia (W.F. Gattaz & G. Busatto, Eds), Springer, New York 2010; pp 377-385. 

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C, et al, [ inc. Stanton A]. Genome-wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension. PLoS Genet 2010;6(10):e1001177.

Peace A, McCall M, Tedesco T, Kenny D, Conroy RM, Foley D, Cox D. The role of weight and enteric coating on aspirin response in cardiovascular patients. J Thromb Haemost. 2010;8:2323-5.

Petersen H, Keane C, Jenkinson HF, Vickerman MM, Jesionowski A, Waterhouse J, Cox D, Kerrigan SW. Human platelets recognize a novel surface protein PadA on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa. Infec Immun 2010;78:413-22.
Raab M, Parthasarathi L, Treumann A, Moran N, Daxecker H. Differential binding of ICln in platelets to integrin-derived activating and inhibitory peptides Biochem Biophys Res Commun 2010;392:258-63.

Raab M, Daxecker H, Edwards RJ, Treumann A, Murphy D, Moran N. Protein interactions with the platelet integrin alpha(IIb) regulatory motif. Proteomics. 2010;10:2790-800.

Ramstrom S, O'Neill S, Dunne E, Kenny D. Annexin V binding to platelets is agonist, time and temperature dependent. Platelets 2010;21:289-96.

Raychaudhuri S, Korn JM, McCarroll SA; International Schizophrenia Consortium [including Waddington JL], Altshuler D, Sklar P, Purcell S, Daly MJ. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genet. 2010;6(9).

Roche E, Clarke M, Browne S, Turner N, McTuige O, Kamali M, Kinsella A, Larkin C, Waddington JL, O'Callaghan E. Prevalence and clinical correlates of depression in the acute phase of first episode schizophrenia. Ir J Psychol Med 2010;27:15-18.

Satchell CS, Cotter AG, O'Connor EF, Peace AJ, Tedesco AF, Clare A, Lambert JS, Sheehan GJ, Kenny D, Mallon PW. Platelet function and HIV: A case-control study. AIDS 2010;24:649-57.

Stanton AV, Gradman AH, Schmieder RE, Nussberger J, Sarangapani R, Prescott MF. Aliskiren Monotherapy does not cause paradoxical blood pressure rises. Meta-analysis of data from 8 clinical trials. Hypertension 2010;55:54-60.

Sharp AS, Tapp RJ, Thom SAM, Francis DP, Hughes AD, Stanton AV, Zambanini A, O'Brien E, Chaturvedi N, Lyons S, Byrd S, Poulter NR, Sever PS, Mayet J on behalf of the ASCOT Investigators. Tissue Doppler E/E' ratio is a powerful predictor of primary cardiac events in a hypertensive population: an ASCOT substudy. Eur Heart J 2010;31:747-52

Tapp RJ, Sharp ASP, Thom SAM, Hughes AD, Stanton AV, Zambanini A, O'Brien E, Chaturvedi N, Poulter NR, Sever PS, Jamil Mayet J on behalf of the ASCOT Investigators. Tapp RJ, Sharp A, Stanton AV, et al. Differential effects of antihypertensive treatment on left ventricular diastolic dysfunction. An ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. J Am Coll Cardiol 2010;55: 1875-81.

The High-Altitude Genetics Consortium [in alphabetical order: Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins PA, Shianna KV, Tam SC, Tsering N, Veeramah KR, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C, Zhang L, Zhang X, Zhaxi P, Zheng YT. "Natural selection on EPAS1 (HIF2a) associated with low hemoglobin concentration in Tibetan highlanders". Proc Natl Acad Sci USA 2010;107:11459-64.

Tomiyama K, Song L, Kobayashi M, Kinsella A, Kanematsu T, Hirata M, Koshikawa N, Waddington JL. Orofacial movements in phospholipase C-related catalytically inactive protein (PRIP)-1/2 double knockout mice: effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959. Synapse 2010;64:714-20.

Vangjeli C, Clarke N, Quinn U, Dicker P, Tighe O, Ho C, O'Brien E, Stanton AV. Confirmation that the renin gene distal enhancer polymorphism, REN-5312C/T is associated with increased blood pressure. Circ Cardiovasc Genet 2010;3:53-9.

Walsh J, Tighe O, Laie D, Harvey R, Karayiorgou M, Gogos JA, Waddington JL, O'Tuathaigh CMP. Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. Brain Res 2010; 1348:114-9.

Witt NW, Chapman N, Thom SA, Stanton AV, Parker KH, Hughes AD. A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations. Artery Res 2010;4:75-80.

Waddington JL, O'Tuathaigh CM, & Remington GJ. The pharmacology and neuroscience of antipsychotic drugs. In: Schizophrenia, Third Edition (D.R. Weinberger & P.J. Harrison, Eds), Wiley-Blackwell, Oxford 2010; pp. 485-514.