Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Publications 2018

Annett S. and Robson T.  Targeting cancer stem cells in the clinic: current status and perspectives.    Pharmacol Ther. 2018 Jul;187:13-30.  PMID: 29421575.

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium [including Waddington J]. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell. 2018 Jun 14;173(7):1705-1715.  PMID: 29906448.

Boakye D, Wyse CA, Morales-Celis CA, Biello SM, Bailey MES, Dare S, Ward J, Gill JMR, Pell JP, Mackay DF. Tobacco exposure and sleep disturbance in 498 208 UK Biobank participants  J Public Health (Oxf). 2017 Aug 30:1-10. PMID: 29040744.

Brainstorm Consortium [including McCormack MWhelan CD, Waddington J]. Analysis of shared heritability in common disorders of the brain.  Science. 2018 Jun 22;360(6395). PMID: 29930110.

Byrne T, Nelson L, Beirne JP, Sharpe D, Quinn JE, McCluggage WG, Robson T, Furlong F.  BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma. Int J Gynecol Cancer. 2018 Mar;28(3):472-478.  Int J Gynecol Cancer. 2018 Mar;28(3):472-478.  PMID:29465507.

Chalissery AJ, Gaughan M, Haughton G, Mullins G, Delanty N. Teaching Video NeuroImages: Vagoglossopharyngeal neuralgia mimicking a seizure. Neurology. 2018 Mar 27;90(13):e1179. PMID: 29581336.

Chalissery AJ, Murphy E, Mullins G, Widdess-Walsh P, Kilbride R, Delanty N. Recurrent catamenial status epilepticus: Is it rare or an under recognized phenomenon in women with epilepsy?  Epilepsy Behav Case Rep.  2017 Oct 21;9:19-21. eCollection 2018.   PMID:  29692964. 

Colas RA, Souza PR, Walker ME, Burton M, Marques RM, Zaslona Z, Curtis AM, Dalli J.  Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increases Systemic Inflammation and Cardiovascular Disease. Circ Res. 2018 Mar 16;122(6):855-863. PMID: 29437834.

Cole G, Ali AA, McCrudden CM, McBride JW, McCaffrey J, Robson T, Kett VL, Dunne NJ, Donnelly RF, McCarthy HO.   DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system.    Eur J Pharm Biopharm. 2018 Jun;127:288-297. PMID:29510205.

Cox D, Fitzgerald D.  Lack of bioequivalence among low-dose, enteric-coated aspirin preparations.  Clin Pharmacol Ther. 2018 Jun;103(6):1047-1051   PMID: 28905988.

Curtin C, Nolan JC, Conlon R, Tan YJ, Gallagher C, Deneweth L, Cavanagh BL, Asraf AZ, Bray I, Harvey H, Miller-Delaney S, O'Brien FJ, Stallings RL, Piskareva O.  A physiologically relevant 3D collagen-based scaffold - neuroblastoma cell system exhibits chemosensitivity similar to orthotopic xenograft models. Acta Biomater. 2018 Apr 1;70:84-97.  PMID: 29447961.

Das S, Moran B, Perry A. Assessing DNA methylation in cancer stem cells. Methods Mol Biol.  2018;1692:157-178. PMID: 28986896.

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.  Proc Natl Acad Sci U S A.  2018 Sep 4;115(36):E8460-E8468. PMID: 30127006.

Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS,  et al., including Cavalleri GL, & Gilbert E.

Ancient genomes from Iceland reveal the making of a human population.  Science. 2018 Jun 1;360(6392):1028-1032.  PMID: 29853688.

Fallon PG, Lavin M, O'Donnell JS. SIPPET - insights into factor VIII immunogenicity. J Thromb Haemost. 2018 Jan;16(1):36-38 PMID: 29080389.

Fogarty H, Byrne M, Niamh M. O’Connell NM, Ryan K, White B, O’Donnell JSLavin M.    Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding. Irish Medical Journal. 2018;111(5)757.

Fogarty H,  Doyle MM, Campbell RC,  Keenan C, White B, Ryan K, O’ Donnell J, Slevin J, O’Keeffe D, O’Connell NM, Lavin M.  Management of combined factor V and factor VIII deficiency in pregnancy. J Obstet Gynaecol. 2018 Apr 18:1-2. PMID: 29667457. 

Garciarena CD, Malik A, Swietach P, Moreno AP, Vaughan-Jones RD.  Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication. FASEB J. 2018 Apr;32(4):1969-1981   PMID: 29183963. 

Gilbert E, O'Reilly S, Merrigan M, McGettigan D, Molloy AM, Brody LC, Bodmer W, Hutnik K, Ennis S, Lawson DJ, Wilson JF, Cavalleri GLThe Irish DNA Atlas: Revealing fine-scale population structure and history within Ireland. Sci Rep. 2017 Dec 8;7(1):17199. PMID: 29222464.

Kavanagh N, O’Brien FJ, Kerrigan SW. Staphylococcus aureus protein A causes osteoblasts to hyper- mineralise in a 3D extra-cellular matrix environment.    PLoS One. 2018 Jun 21;13(6):e0198837. eCollection 2018. PMID: 29927956.

Kavanagh N, Ryan EJ, Widaa A, Sexton G, Fennell J, O’Rourke S, Cahill KC, Kearney CJ, O’Brien FJ, Kerrigan SW. Staphylococcus Osteomyelitis – Disease progression, treatment challenges and future directions.  Clin Microbiol Rev. 2018 Feb 14;31(2).  PMID: 29444953.

Kennedy C, Wong L, Sexton DJ, Cowman J, Oglesby I, Kenny M, Conlon P, and Kenny D.  Successful kidney transplantation normalizes platelet function.  Clinical Kidney Journal, 2018, 1–7. doi: 10.1093/ckj/sfx148.

Kenny C, McDonagh N, O’Meara E, Klinger R, O’Connor DP, Roche F, Hokamp K, O’Sullivan MJ. Dysregulated cell signalling as an oncogenic basis for the development of clear cell sarcoma of the kidney (CCSK)  J Pathol. 2018 Mar;244(3):334-345.  PMID: 29243812. 

Kingston T, Scully PJ, Browne DJ, Baldwin P, Kinsella A, O’Callaghan E, Russell V, Waddington JL. Functional outcome and service engagement in major depressive disorder with psychotic features: comparisons with schizophrenia, schizoaffective disorder and bipolar disorder in a 6-year follow-up of the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS).   CNS Neurosci Ther. 2018 Jul;24(7):633-640. PMID: 29575682. 

Kong XZ, Mathias SR, Guadalupe T; ENIGMA Laterality Working Group, Glahn DC, Franke B, Crivello F, Tzourio-Mazoyer N, Fisher SE, Thompson PM, Francks C. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.  Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5154-E5163. PMID: 29764998.

Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O'Connell NM, O'Sullivan JM, Di Paola J, James PD, O'Donnell JS. Significant gynecological bleeding in women with low von Willebrand factor levels.Blood Adv. 2018 Jul 24;2(14):1784-1791.  PMID: 30042144.

Lavin M, Ryan K, White B, Byrne M, O'Connell NM, O'Donnell JS. A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy.   Haemophilia. 2018 Jan;24(1):e22-e25. PMID:  29168278. 

Lickert S, Sorrentino S, Studt J. D, Medalia O, Vogel V, Schoen I.  Morphometric analysis of spread platelets identifies integrin aIIbß3-specific contractile phenotype.  Sci Rep. 2018 Apr 3;8(1):5428. PMID: 29615672. 

Lyall LM, *Wyse CA, Celis-Morales CA, Lyall DM, Cullen B, Mackay D, Ward J, Graham N, Strawbridge RJ, Gill JMR, Ferguson A, Bailey MES, Pell JP, Curtis AM, Smith DJ.  Seasonality of depressive symptoms in women but not in men: A cross-sectional study in the UK Biobank cohort.  J Affect Disord. 2018 Jan 4;229:296-305.PMID: 29329063. [equal contributions].

Lyons VG, Payne NL, McCoy CE. Optimization Techniques for miRNA expression in low frequency immune cell populations. Methods Mol Biol.  2018;1725:237-256.  PMID: 29322422.

May P, Girard S, Harrer M, Bobbili DR, Schubert J, Wolking S, Becker F, Lachance-Touchette P, et al including. Cavalleri G., Gilbert E. Rare coding variants in genes encoding GABAA receptors in genetic generalised epilepsies: an exome-based case-control study. Lancet Neurol. 2018 Aug;17(8):699-708.  PMID: 30033060

McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S,  et al incl. Stanton AV. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis. 2017 Dec 8;269:42-49. PMID:29258006.

McCormack M, Gui H,  Ingason A, Speed D, Wright GEB, Zhang EJ, Secolin R, et al, incl. Delanty N, Cavalleri G.  Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. Neurology. 2018 Jan 23;90(4):e332-e341. PMID: 29288229. 

McCrudden C, McBride JW, McCaffrey J, McErlean EA, Dunne NJ, Kett VL, Coulter JA, Robson T. and O. McCarthy H.  Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer.  Cancer Nano (2018) 9:5.

McDonnell CJ, Soule EE, Walsh PT, O'Donnell JS, Preston RJS. The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease.  Semin Thromb Hemost. 2018 Mar;44(2):167-175  PMID: 29232721. 

McHale TM, Garciarena CD, Fagan RP, Smith GJS, Martin-Loches, Curley GF, Fitzpatrick F, Kerrigan SW. Inhibition of vascular endothelial cell leak following Escherichia coli attachment in an experimental model of sepsis. Crit Care Med. 2018 Aug;46(8):e805-e810.  PMID: 29782355.

Monopoli MP, Zendrini A , Wu D , Cheung S , Sampedro G , Ffrench B , Nolan J , Piskareva O , Stalings RL , Ducoli S , Bergese P , O'Shea DF .Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe. Chem Commun (Camb). 2018 Jun 26;54(52):7219-7222.

Nejad C, Pillman KA, Siddle KJ, Pepin G, Änkö ML, McCoy CE,  et al.  miR-222 isoforms are differentially regulated by type-I interferon. RNA. 2018 Mar;24(3):332-341.    PMID:29263133. 

Ni G, Gratten J, Wray NR, Lee SH, Schizophrenia Working Group of the Psychiatric Genomics Consortium [including Waddington J]. Age at first birth in women is genetically associated with increased risk of schizophrenia. Sci Rep. 2018 Jul 5;8(1):10168.  PMID: 29977057.

Ni G, Moser G, Schizophrenia Working Group of the Psychiatric Genomics Consortium [including Waddington J.], et al. Estimation of genetic correlation via linkage disequilibrium score regression and genomic restricted maximum likelihood. Am J Hum Genet. 2018 Jun 7;102(6):1185-1194. PMID: 29754766.

O'Grady S, Morgan MP. Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis. Biochim Biophys Acta. 2018 Apr 21;1869(2):310-320.  PMID: 29684522.  

O'Halloran JA, Dunne E, Tinago W, Denieffe S, Kenny D, Mallon PWG.  Switching from abacavir to tenofovir disoproxil fumarate is associated with rises in soluble glycoprotein VI, suggesting changes in platelet-collagen interactions.  
AIDS. 2018 Apr 24;32(7):861-866.  PMID:  29438200.

Olsson AAlfredsson JRamström SSvedjeholm RKenny D, Håkansson EBerglund JSBerg S.  Better platelet function, less fibrinolysis and less hemolysis in re-transfused residual pump blood with the Ringer's chase technique - a randomized pilot study.  Perfusion. 2018 Apr;33(3):185-193.   PMID: 28950757.

O’Sullivan J.M, O’Donnell, J.S. Platelets in malaria pathogenesis. Blood. 2018 Sep 20;132(12):1222-1224. PMID: 30237255.

O'Sullivan JM, Preston RJSRobson TO'Donnell JS.  Emerging roles for von Willebrand Factor in cancer cell biology. Semin Thromb Hemost. 2018 Mar;44(2):159-166.    PMID: 29165741.  


Preston RJS, Lisman T. Extrahemostatic Functions of Platelets and Coagulation Factors.  Semin Thromb Hemost. 2018 Mar;44(2):89-90. PMID: 29471579.

Ren Z, Yan P, Zhu L, Yang H, Zhao Y, Kirby BP, Waddington JL, Zhen X. Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation. Psychopharmacology (Berl). 2018 Jan;235(1):233-244. PMID: 29058041.

Ryan AJ, Kearney CJ, Shen N, Khan U, Kelly AG, Probst C, Brauchle E, Biccai S, Carciarena CD, Kerrigan SW, Kelly DJ, Schenke-Layland K, Coleman JN, O'Brien FJ. Electroconductive biohybrid collagen and pristine graphene composite biomaterials with enhanced biological activity.  Adv Mater.  2018 Apr;30(15):e1706442     PMID: 29504165.

Sen A, Dugan P, Perucca P, Costello D, Choi H, Bazil C, Radtke R, Andrade D, Depondt C, Heavin S, Adcock J, Pickrell WO, McGinty R, Nascimento F, Smith P, Rees MI, Kwan P, O'Brien TJ, Goldstein D, Delanty N. The phenotype of bilateral hippocampal sclerosis and its management in "real life" clinical settings.  Epilepsia. 2018 Jul;59(7):1410-1420. PMID: 29901232.

Sheilds S, Conroy E, O' Grady T, McGoldrick A, Connor K, Ward M, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas D, Kay E, O' Connor D, McCann A, Gallagher WM,  Coppinger JA .  BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in Triple Negative Breast Cancer.  Oncotarget. 2018; 9:15673-15690. 

Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, Mills KHG, Curtis AM. Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.  Nat Commun. 2017 Dec 12;8(1):1923. PMID: 29234010. 

Synnott N, Bauer MR, Madden S, Murray A, Klinger R, O'Donovan N, O'Connor DP, Gallagher WM, Crown J, Fersht AR, Duffy MJ. Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.   Cancer Lett. 2018 Feb 1;414:99-106  PMID: 29069577. 

Tighe O, Strawbridge J, McGarvey A,  McGee H. The white coat ceremony – An opportunity for interprofessional socialization. Journal of Interprofessional Care, 2018:  ( 

van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, et al including Das S,  O'Connor DP.  Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With MetastaticColorectal Cancer Treated With Bevacizumab.  J Clin Oncol. 2018 Jul 10;36(20):2052-2060.  PMID: 29792754.

Villanueva V, Holtkamp M, Delanty N, Rodriguez-Uranga J, McMurray R, Santagueda P.   Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.   J Neurol. 2017 Nov;264(11):2232-2248.   PMID: 28921040.

Waddington JL. Why Does the Goalkeeper Eschew Medication? The Challenge of New Treatments for Tourette Syndrome.  Mov Disord. 2018 Aug;33(8):1236-1237. PMID: 30230630.


Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, et al incl. Stanton AV. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.  Hypertension, 2017, 70(3), e4-e19.  PMID: 28739976. 

Ward J, Dunne E, Bishop D, Boyd A, Kenny D, Meenan B. Entrapment of Autologous von Willebrand Factor on Polystyrene/Poly(methyl methacrylate) Demixed Surfaces.    Polymers 20179(12), 700; doi:10.3390/polym9120700

Ward SEO'Sullivan JM, Drakeford C, Aguila S, Jondle CN, Sharma J, Fallon PG, Brophy TM, Preston RJS, Smyth P, Sheils O, Chion AO'Donnell JS.    A novel role for the macrophage galactose-type lectin (MGL) receptor in mediating von Willebrand factor clearance. Blood. 2018 Feb 22;131(8):911-916.   PMID: 29282218.

Ward E, Varešlija D, Charmsaz S, Fagan A, Browne AL, Cosgrove N, Cocchiglia S, Purcell S, Hudson L, Das S, O’Connor DP, O’Halloran P, Sims A, Hill AD, Young LS.  Epigenome-wide SRC-1 mediated gene silencing represses cellular differentiation in advanced breast cancer.  Clin Cancer Res. 2018 Aug 1;24(15):3692-3703.    PMID: 29567811. 

Watanabe Y, Aono Y, Komiya M, Waddington JL, Saigusa T. Stimulation of accumbal GABAB receptors inhibits delta1- and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats. Eur J Pharmacol. 2018 Aug 5;837:88-95.  PMID: 30086266.

Watkin R,Fitzpatrick GG, Kerrigan SW. The Evolving role of microRNAs in endothelial cell dysfunction following infection.  Semin Thromb Hemost. 2018 Apr;44(3):216-223  PMID: 29294494.

Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, Absil J, Alhusaini S, et al [incl. Cavalleri G]. Structural brain abnormalities in the common epilepsies  assessed in a worldwide ENIGMA study.  Brain. 2018 Feb 1;141(2):391-408  . PMID: 29365066.  

Wyse CA, Celis Morales CA, Ward J, Lyall D, Smith DJ, Mackay D, Curtis AM, Bailey MES, Biello SM, Gill JMR, Pell JP.  Population-Level Seasonality in Cardiovascular Mortality, Blood Pressure, BMI and Inflammatory Cells.  Ann Med. 2018 May 18:1-10. PMID: 29724143.

Wyse CA, Zhang X, McLaughlin M, Biello SM, Hough D, Bellingham M, Curtis AM, Robinson JE, Evans NP.  Circadian Rhythms of Melatonin and Behaviour in Juvenile Sheep in Field Conditions: Effects of Photoperiod, Environment and Weaning.  Physiol Behav. 2018 Oct 1;194:362-370. PMID: 29894760.

Yiming Li, Mund M, Hoess P, Deschamps J, Matti U, Nijmeijer B, Jimenez Sabinina V, Ellenberg J, Schoen I. & Ries J. Real-time 3D single-molecule localization using experimental point spread functions.    Nat Methods. 2018 May;15(5):367-369.  PMID: 29630062.

Zhen X, Waddington J. Emerging and evolving concepts in the pathobiology and treatment of psychosis.  CNS Neurosci Ther. 2018 Jul;24(7):583-585. PMID: 29898285.