Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Publications 2017

 

  • Adams HH, et al [includling Delanty N.]   A Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 Dec;19(12):1569-1582.  PMID: 27694991.

  • Ali AA, McCrudden CM, McCaffrey J, McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO.  DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles.   Nanomedicine. 2016 Dec 12;13(3):921-932. PMID: 27979747.
  •  Al Hannan FAO'Farrell PAMorgan MPTighe OCulligan KG.  Associations between single-nucleotide polymorphisms of ADIPOQ, serum adiponectin and increased type 2 diabetes mellitus risk in Bahraini individuals. East Mediterr Health J. 2016 Nov 2;22(8):611-618. PMID: 27834443.

  • Bajrangee A, Ryan N, Vangjeli C, Brennan M, Cox D, Shields DC, Fitzgerald D, Maree A. Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin. Thromb Res. 2016 Oct;146:51-55. PMID: 27597145.
  • Brennan MP. Deadly Engagement: Fc?RIIa-Antibody Interaction is Key in Sepsis. Trends Pharmacol Sci. 2016 Dec;37(12):989-990. PMID: 27992320.

  •  Brophy T, Ward SE, McGimsey T, Schneppenheim S, Drakeford CO'Sullivan JMChion A, Budde U, O'Donnell J.  Plasmin Cleaves von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Mannerin vitro. Arterioscler Thromb Vasc Biol. 2017 May;37(5):845-855.  PMID: 28279966.   

  • Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils, O, Laffan M, McKinnon TA, O'Donnell JS. N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance. Blood. 2016 Oct 13;128(15):1959-1968. PMID: 27554083. 
  • Cole AM, Cox S, Jeong C, Petousi N, Aryal DR, Droma Y, Hanaoka M, Ota M, Kobayashi N, Gasparini P, Montgomery H, Robbins P, Di Rienzo A, Cavalleri GL.   Genetic structure in the Sherpa and neighboring Nepalese populations.  BMC Genomics. 2017 Jan 19;18(1):102. PMID: 28103797.
  • Cowman J, Müllers SM, Dunne E, Ralph A, Ricco AJ, Malone FD, Kenny D. Platelet behaviour on von Willebrand Factor changes in pregnancy: Consequences of haemodilution and intrinsic changes in platelet function. Sci Rep. 2017 Jul 25;7(1):6354. doi: 10.1038/s41598-017-06959-6.  PMID: 28743915.  

  • Cowman J, Quinn N, Geoghegan S, Müllers S, Olgesby I, Byrne B, Somers M, Ralph A, Voisin B, Ricco AJ, Molloy EJ, Kenny D.  Dynamic platelet function on von Willebrand factor is different in preterm neonates compared with full-term neonates: changes in neonatal platelet functionJ Thromb Haemost. 2016 Oct;14(10):2027-2035 PMID: 27416003.
  • CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium. [including Waddington J]. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017 Jan;49(1):27-35. PMID: 27869829. 

  • Das S, Moran B, Han K, Mulligan N, Barrett C, Buckley PG, Mc Mahon P, Mc Caffrey J, Van Essen HF, Connor K, Ylstra B, Lambrechts D, Gallagher WM, O’Connor DP, Kelly CM. Post-mortem examination of an aggressive case of medullary thyroid carcinoma characterized by catastrophic genomic abnormalities.   JCO Precision Oncology. no. 1 (June 2017) 1-7. http://ascopubs.org/doi/full/10.1200/PO.16.00063.   

  • Delanty N, Cavallleri G. Genomics-Guided Precise Anti-Epileptic Drug Development. Neurochem Res. 2017 Jul;42(7):2084-2088. PMID: 28608234.
  • Desbonnet L, Cox R, Tighe O, Lai D, Harvey RP, Waddington JL, O'Tuathaigh CM. Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1×DISC1. Behav Brain Res. 2016 Dec 1;320:113-118. PMID: 27916686.
  • Dwane L, Gallagher WM, Ní Chonghaile T, and O’Connor DP. The Emerging Role of Nontraditional Ubiquitination in Oncogenic Pathways. J Biol Chem. 2017 Mar 3;292(9):3543-3551. PMID: 28154183.
  • Early JOCurtis AM. Immunometabolism: Is it under the eye of the clock? Semin Immunol. 2016 Oct;28(5):478-490. PMID: 27884543. 

  • Egan K, Dillon A, Dunne E, Kevane B, Galvin Z, Maguire P, Kenny D, Stewart S, Ainle FN. Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation.  J Thromb Thrombolysis. 2017 Jan;43(1):54-59.    PMID: 27416950.
  • Epi4K Consortium [including Cavalleri G, Delanty N, McCormack M.]. Phenotypic analysis of 303 multiplex families with common epilepsies.  Brain. 2017 Aug 1;140(8):2144-2156.  PMID: 28899008.

  • Feuillie C, Formosa-Dague C, Hays LMC,  Vervaeck O, Derclaye S, Brennan M, Foster TJ, Geoghegan JA, Dufresne YF.  Biofilm accumulation by the staphylococcal protein SdrC: molecular mechanism and inhibition.   Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3738-3743.   PMID: 28320940.

  • Garciarena C, McHale T, Martin-Loeches I, Kerrigan SW.  Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis. Crit Care. 2017 Sep 26;21(1):246  PMID: 28946901

  • Gu R, Zhang F, Chen G, Han C, Liu J, Ren Z, Zhu Y, Waddington JL, Zheng LT, Zhen X. Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming. Brain Behav Immun. 2017 Feb;60:206-219. PMID: 27769915.
  • Håkansson K, Runker AE, O'sullivan GJ, Mitchell KJ, Waddington JL, O'Tuathaigh CM. Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning.  Neurosci Lett. 2017 Feb 22;641:70-76. PMID: 28109776.  
  • Haworth JA, Jenkinson HF, Petersen H, Beck CR, Brittan JL, Kerrigan SW, Nobbs AH. Concerted functions of Streptococcus gordonii surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix. Cell Microbiol. 2017 Jan;19(1). PMID: 27616700.   
  • Kavanagh N, O’Brien FJ, Kerrigan SW.  The molecular mechanics of inflammatory bone disease caused by infection. In: Kon K, Rai M (eds) Microbiology of skin and soft tissue infections. Elsevier Publishers.  Chpt 11, ISBN 978-012-81-1079-9. 

  • Li B, Ni Chonghaile T, Fan Y, Madden S, Klinger R, O'Connor AE, Walsh L , O’Hurley G, Mallya G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Dubois T, Linn S, Jirstrom K, Caldas C, O'Connor DP* & Gallagher WM*.Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer. *Shared Senior Authorship. Cancer Res. 2017 Jul 15;77(14):3834-3845. PMID:  28455421.
  • McCarthy C, Orr C, Fee L, Dunlea DM, Hunt DJL, Dunne E, Carroll TP, O'Connell P, McCarthy G, Kenny D, Fearon U, Veale DJ, Reeves EP, McElvaney NG.  Brief Report: Genetic variation of the alpha-1-antitrypsin gene is associated with increased autoantibody production in rheumatoid arthritis.     Arthritis Rheumatol. 2017 Aug;69(8):1576-1579.  PMID: 28409899.

  • McCoy CE  miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis. Adv Exp Med Biol. 2017;1024:111-131.  PMID: 28916584.

  • McCrudden C, McBride J, McCaffrey J, Ali A, Dunne N, Kett V, Coulter J, Robson T, and McCarthy H.  Systemic RALA/iNOS nanoparticles; a potent gene therapy for metastatic breast cancer coupled as a biomarker of treatment. Mol Ther Nucleic Acids. 2017 Mar 17;6:249-258.  PMID: 28325291.

  • McDonnell C, Garciarena C, Watkin R, McHale T, McLoughlin A, Claes J, Verhamme P, Cummins P, Kerrigan SW. Inhibition of major integrin αV β3 reduces Staphylococcus aureus attachment to sheared human endothelial cells.  J Thromb Haemost. 2016 Dec;14(12):2536-2547. PMID: 27606892.
  • McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP. Trypanosoma brucei metabolite indolepyruvate decreases HIF-1a and glycolysis in macrophages as a mechanism of innate immune evasion. Proc Natl Acad Sci U S A2016 Nov 29;113(48):E7778-E7787. PMID: 27856732.
  • McLaughlin RL et al [including Waddington J]. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.  Nat Commun. 2017 Mar 21;8:14774. PMID: 28322246.
  • McLoughlin A, Rochford K, McDonnell C, Kerrigan SW, Cummins P. Staphylococcus aureus-mediated blood-brain barrier injury: An in vitro human brain microvascular endothelial cell model.  Cell Microbiol. 2017 Mar;19(3). PMID: 27598716.
  • Moran B*,Das S *, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JHM, Bacon O, Kay E, Hennessy B, Amberger-Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM & O’Connor DP. Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.  (*Shared first authorship). Oncotarget. 2017 Jul 18;8(29):48126-48137. PMID: 28611295.

  • Moran P, Stokes J, Marr J, Bock G, Desbonnet L, Waddington JL, O’Tuathaigh C. Gene-environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plast. 2016;2016:2173748. PMID: 27725886. 

  • Mulrane L, Gallagher WM, O'Connor DP. Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology. Methods Mol Biol. 2017;1501:311-325. PMID: 27796961. 
  • Murray A, Madden S, Synnott NC, Klinger R, O’Connor DP, O’Donovan N, Gallagher WM, Crown JP, Duffy MJ. Vitamin D receptor as a target for breast cancer therapy.  Endocr Relat Cancer. 2017 Apr;24(4):181-195.  PMID: 28213567.
  • O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS. N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor. J Thromb Haemost. 2016 Dec;14(12):2446-2457. PMID: 27732771.
  • Ott C, Lobo MD, Sobotka PA, Mahfoud F, Stanton AV, Cockcroft J, Sulke N. et al.  Effect of Arteriovenous Anastomosis on Blood Pressure Reduction in Patients With Isolated Systolic Hypertension Compared With Combined Hypertension. J Am Heart Assoc. 2016 Dec 21;5(12). PMID:28003251.
  • O'Tuathaigh CM, Fumagalli F, Desbonnet L, Perez-Branguli F, Moloney G, Loftus S, O'Leary C, Petit E, Cox R, Tighe O, Clarke G, Lai D, Harvey RP, Cryan JF, Mitchell KJ, Dinan TG, Riva MA, Waddington JL. Epistatic and independent effects on schizophrenia-related phenotypes following co-disruption of the risk factors neuregulin-1 × DISC1. Schizophr Bull. 2017 Jan;43(1):214-225. PMID: 27613806.
  • O’Tuathaigh CMP, Moran PM, Zhen XC, Waddington JL.  Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.  Br J Pharmacol. 2017 Oct;174(19):3173-3190.    PMID: 28667666.

  • Petit EI, Michalak Z, Cox R, O'Tuathaigh CM, Clarke N, Tighe O, Talbot K, Blake D, Joel J, Shaw A, Sheardown SA, Morrison AD, Wilson S, Shapland EM, Henshall DC, Kew JN, Kirby BP, Waddington JL. Dysregulation of specialized delay/interference-dependent working memory following  loss of dysbindin-1A in schizophrenia-related phenotypes.  

    Neuropsychopharmacology. 2017 May;42(6):1349-1360.  PMID: 27986973.

     

  • Postmus I, et al [including Stanton AV]. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.  J Med Genet. 2016 Dec;53(12):835-845.  PMID: 27587472
  • Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel, C, Behl C, Coppinger JA. Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis.   Sci Rep. 2017 Aug 9;7(1):7642.  PMID: 28794469.
  • Saigusa T, Aono Y, Waddington JL . Mechanisms of delta- and mu-opioid receptor agonist-induced increases in extracellular dopamine level in the nucleus accumbens of freelymoving rats. J Oral Sci. 2017;59(2):195-200. PMID: 28637978.   
  • Streubel G, Fitzpatrick DJ, Oliviero G, Das S , Moran B, Manuwar N, Watson A, Wynne K, Scelfo A, Jammula S, Hokamp K,O'Connor DP , Pasini D, Cagney G, Bracken AP.  Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.   EMBO J. 2017 Aug 1;36(15):2216-2232.   PMID: 28554894.

  • Spain E, Adamson K, Elshahawy M, Bray I, Keyes TE, Stallings RL, Forster RJ.  Hemispherical platinum : silver core : sell nanoparticles for miRNA detection.   Analyst. 2017 Feb 27;142(5):752-762. PMID: 28091676.

  • Synnott NC, Murray A, McGowan PM, Kiely M, Kiely PA, O'Donovan N, O'Connor DP, Gallagher WM, Crown J, Duffy MJ.  Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?  Int J Cancer. 2017 Jan 1;140(1):234-246. PMID:  27615392. 
  •  Villanueva V, Holtkamp M, Delanty N, Rodriguez-Uranga J, McMurray R, Santagueda P.   Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.  J Neurol. 2017 Nov;264(11):2232-2248.  PMID: 28921040.

  • Warren HR, [inc. Stanton AV], UK Biobank CardioMetabolic Consortium BP working group. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.  Nat Genet. 2017 Mar;49(3):403-415. PMID: 28135244. 
  • Williams J, Mullins G, Delanty N, Peter B, Doherty CP.  The spectrum of peri-ictal MRI changes; four illustrative cases. Seizure. 2017 Aug;50:189-193.   PMID:  28709144.  

  • Wyse CA, Celis CA, Graham N, Ward J, Curtis AM, Mackay D, Smith DJ, Bailey M, Biello S, Gill JMR, Pell JP.  Adverse Metabolic and Mental Health Outcomes Associated with Shiftwork in a Population-Based Study of 277 168 Workers in UK Biobank. Ann Med. 2017 Feb 6:1-23.  PMID: 28166415.  

  • Zaslona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM*, O'Neill LA*.  The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.  Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L855-L860.  PMID: 28336811.
  • Zapotoczna M, Boksmati N, Donohue S, Bahtiar B, Boland A, Al Somali H, Cox A, Humphreys H, O'Gara JP, Brennan M, O’Neill E.. Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds; MMV665953 (1-(3-Chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea) and MMV665807 (5-Chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide. J Med Microbiol. 2017 Mar;66(3):377-387.   PMID: 28327271.
  • Zuurbier L, Rahman A, Cordes M, Scheick J, Wong T, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B,O’Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen A, van Grieken N, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM & Postel R.   Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.   Oncotarget. 2017 Jun 27;8(26):42949-42961.  PMID: 28487489.