Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Industry Fully Funded Research Project

Our research project with RCSI has significantly advanced our understanding of the challenges in therapeutic protein drug delivery and has provided a sound basis for further R&D which we hope will lead to a commercial application.

Dr John Devane
Group Vice President and General Manager
Horizon Pharma

Project Title

Anti-inflammatory drug delivery

Engagement type

Industry Fully Funded Research Project

Industry partner

Horizon Pharma plc is a specialty biopharmaceutical company focused on improving patients’ lives by identifying, developing, acquiring and commercializing differentiated products that address unmet medical needs. The company markets a portfolio of products in arthritis, inflammation and orphan diseases.

Challenge

While the potential of protein-based therapies in treating disease is widely recognised, the clinical and commercial translation of biotherapeutics can be limited by suboptimal pharmacokinetics, biochemical instability, adverse effects and inefficient delivery. This engagement focused on testing novel delivery technologies for a protein-based therapeutic with a particular focus on formulation, pharmaceutical characterisation and pharmacokinetics.

RCSI value-add

A dynamic multidisciplinary research team in RCSI’s School of Pharmacy with access to state-of-the art facilities and a proven track record of working in and with the BioPharma industry. RCSI performed protein characterisation studies, in vitro and preclinical in vivo pharmacokinetics and provided advice on pharmaceutical formulation.