Home > Medical and Health Sciences > School of Pharmacy > Staff Details > Prof. Kevin B. Nolan > 

Professor Kevin B Nolan

Professor Kevin B Nolan PhD, DSc (NUI), FRSC

Professor of Pharmaceutical and Medicinal Chemistry

Email: kbnolan@rcsi.ie

Department of Pharmaceutical and Medicinal Chemistry

Biography:

Kevin B. Nolan graduated with a BSc degree from University College Galway in 1969 and obtained his PhD under the supervision of Prof. Sean O’Cinneide from the same University in 1972. He carried out post-doctoral research with Prof. R.W. Hay at the University of Stirling and held lecturing positions at University College London (1974-75) and the University of Surrey (1975-87) before taking up his present appointment as Professor of Chemistry at the Royal College of Surgeons in Ireland in 1987

Research Interests:

• Synthesis of hydroxamic acid analogues of aspirin as inhibitors of cyclooxygenase
• Hydroxamic acids as nitric oxide donors; ruthenium-hydroxamate complexes.
• Synthesis of platinum(II) and platinum(IV) complexes as possible antitumour drugs.
  
  

Selected Publications:

Representative Publications

1.The Productive Conformation of PGG2 at the Peroxidase Site of Prostaglandin Endoperoxide H Synthase. A. J. Chubb, D. J. Fitzgerald, and K. B. Nolan and E.Moman, Biochemistry, 2006; 45(3); 811-820

2.Speciation, stability constants and structures of complexes of copper(II), nickel(II), silver(I) and mercury(II) with PAMAM dendrimer and related tetraamide ligands, K. A. Krot, A. F. Danil de Namor , A. Aguilar-Cornejo, and K. B. Nolan, Inorg Chim Acta, 2005, 358, 3497-3505.

3.Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the Prostaglandin H2 Synthase peroxidase activity. J. Lee, A. J. Chubb, E. Moman, B. M. McLoughlin, C. T. Sharkey, J. G. Kelly, K. B. Nolan, D. J. Fitzgerald and M. Devocelle, Org. Biomol. Chem., 2005, 3, 3678 - 3685

4. Calix(4)arene Pyridine Derivative and Its Monomeric Component: Structural and Thermodynamic Aspects of Their complexatio n with Metal Cations,, A.F.Danil de Namor, A. Aguilar-Cornejo, R. Soualhi, M. Shehab, K.B. Nolan, N.Ouazzani and L. Mandi, J. Phys. Chem, 2005, 109, 14795 -14799.

5. Hydroxamic acids - an intriguing family of bioligands and enzyme inhibitors, C.J. Marmion, D. Griffith and K.B. Nolan, Eur. J. Inorg. Chem., 2004, 15, 3003-3016.

6. Synthesis, structures and speciation studies of ruthenium(III)-hydroxamate/ hydroximato complexes. Crystal and molecular structure of hydrated [Ru(H2edta)(2-methoxyphenylhydroxamate)], the first structurally characterised ruthenium (III)-hydroxamate complex. J Comiskey, E. Farkas, K. A. Krot-Lacina, R. G. Pritchard, C. A. McAuliffe (the late) and K. B. Nolan, J. Chem. Soc., Dalton Trans., 2003, 4243 – 4249.

7. A novel family of hydroxamate based acylating inhibitors of cyclooxygenase, C. M. Dooley, M. Devocelle, B. McLoughlin, K. B. Nolan and D. J. Fitzgerald, Mol. Pharmacol. 2003, 63, 450-455.

8. A convenient parallel synthesis of low molecular weight hydroxamic acids using polymer-supported hydroxybenzotriazole, M. Devocelle, B. M. McLoughlin, C. T. Sharkey, D. J. Fitzgerald and K. B. Nolan, Org. Biomol. Chem., 2003, 1, 850 - 853.

9. Gold(III) complexes of amides of EDTA (L, L1) and PDTA (L2, L3) as model systems for gold(III)-peptide/protein interactions. Synthesis of [AuLCl][AuCl4], [AuL2Cl]Cl and related complexes and the crystal and molecular structures of [Au(LH-1)Cl][AuCl4] containing a deprotonated amide ligand and of (LH2)2[AuCl4]3.5 [AuCl2]0.5.2H2O, A. A. Cornejo, A. Castineiras, A. I Yanovsky and K. B. Nolan, Inorg. Chim. Acta, 2003, 349, 91-96.

10. Synthesis and structure of a heptanuclear nickel(II) complex uniquely exhibiting four distinct binding modes, two of which are novel, for a hydroxamate ligand, D. Gaynor, Z. A. Starikova, S. Ostrovsky, W. Haase and K. B. Nolan, J. Chem. Soc., Chem. Commun., 2002, 506-507.

11. Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases, C. J. Marmion, T. Murphy and K.B. Nolan, J. Chem. Soc., Chem. Commun., 2001, 1870-1871.

12. Copper(II) complexes of isomeric aminophenylhydroxamic acids. A novel 'clam-like' dimeric metallacrown and polymeric helical structure containing interlinked unique copper(II) sites, D. Gaynor, Z. A. Starikova, W. Haase and K. B. Nolan, J. Chem. Soc., Dalton Trans., 2001, 1578-1581.

13. O-Acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H-2 -synthase: Structural and functional characterization of enzyme-inhibitor interactions, P. J. Loll, C. T. Sharkey, S. J. O'Connor, C. M. Dooley, E. O’Brien, M. Devocelle, K. B. Nolan, B. S. Selinsky and D. J. Fitzgerald, Mol. Pharmacol., 2001, 60, 1407-1413.

14. Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substitutents. Crystal and molecular structure of [PtL4Cl2]·H2O where L4 is ethylenediamine-N,N' –diacetate, J.N. Jolley, A.I. Yanovsky, L.R .Kelland and K.B.Nolan, J. Inorg. Biochem., 2001, 83, 91-100.

15. Synthesis and characterisation of mercaptoimidazole, mercaptopyrimidine and mercaptopyridine complexes of platinum(II) and platinum(III). The crystal and molecular structures of tetra(2-mercaptobenzimidazole)- and tetra(2-mercaptoimidazole) platinum(II) chloride, J. N. Jolley, W. I. Cross, R. G. Pritchard, C. A. McAuliffe and K. B. Nolan, Inorg. Chim. Acta, 2001, 315, 36-43.

16. Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids, C.J. Marmion, T. Murphy, J.R. Docherty and K.B. Nolan, J. Chem. Soc., Chem. Commun., 2000, 1153-1154.

17. Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl.H2Sha, a model for a peroxidase – inhibitor complex, E. C. O’Brien, E. Farkas , M.J.Gil, D.Fitzgerald , A.Castineiras and K.B. Nolan, J. Inorg. Biochem., 2000, 79, 47-51.

18. Metal complexes of taurine. The first reported solution equilibrium studies for complex formation by taurine at physiological pH; the copper(II)-glycylglycinate-taurine and the copper(II)-glycylaspartate-taurine systems, E.C. O'Brien, E. Farkas, A. Rockenbauer and K.B. Nolan, J. Inorg. Biochem., 1999, 77, 135-139.

Co-editor of 'Perspectives on Bioinorganic Chemistry' (JAI Press), Vols 1-4. Chapter contributor to Royal Society of Chemistry, Specialist Periodical Reports. ‘Amino Acids, Peptides and Proteins’ , Vols 15-27.

Back to top