Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Prof. Marc Devocelle

Staff Section Photo Marc 

Prof. Marc Devocelle, MSc, PhD (Lille)

Associate Professor of Chemistry & RCSI Erasmus Officer
email mdevocelle@rcsi.ie  Tel : +353 1 402 2176


Biography

BSc in Chemistry, University of Lille, 1990
MSc in Organic Chemistry, University of Lille, 1991
Adv Dip Org Chem, University of Lille, 1993
PhD in Organic Chemistry under Prof. André Mortreux and funded by Sanofi, University of Lille,1997

Postdoctoral Research Fellow, Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), 1999
Manager of the Peptide Synthesis Laboratory, RCSI, 2000-2004
Lecturer in Chemistry, RCSI, 2004-2008
Senior Lecturer in Chemistry, RCSI, 2008-2014
Associate Professor of Chemistry, 2014 - present

Servier Award for 'Development of compounds to prevent cardiovascular disease and for research collaborations between Ireland and France', 2006
RCSI Dean's Award for Endeavour, Innovation, Collaboration and Service, 2011

Professional Committees

European Peptide Society
American Chemical Society
American Peptide Society

Research areas

Peptide Chemistry
Peptides and peptidomimetics as drug candidates and investigational tools
Peptide-based drug delivery systems and nanomedicines
Peptide-functionalised biomaterials 

Postgraduate & Postdoctoral Staff

PhD: Mr Eanna Forde.

Postdoc: Dr Andrea Molero Bondia

 Representative Publications   

1. Forde E, Humphreys H, Greene CM, Fitzgerald-Hughes D, Devocelle M. Potential of host defense Peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis. Antimicrob Agents Chemother. 2014, 58(2), 978-85. PMID:24277028

2. Parker JP, Devocelle M, Marmion CJ. Derivatization of the Anti-Cancer Cationic Antimicrobial Peptide P18 and its Complexation to Pt(II). Z. Anorg. Allg. Chem. 2013, 639, (8-9), 1628–1635.

3. Blackmore L, Moriarty R, Dolan C, Adamson K, Forster RJ, Devocelle M, Keyes TE. Peptide directed transmembrane transport and nuclear localization of Ru(ii) polypyridyl complexes in mammalian cells. Chem Commun (Camb), 2013, 49(26), 2658 – 2660. PMID:23435967

4. O’Connor S, Szwej E, Nikodinovic-Runic J, O’Connor A, Byrne AT, Devocelle M, O’Donovan N, Gallagher WM, Babu R, Zinn M, Zulian QR, O'Connor KE. The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate. Biomaterials, 2013, 34(11), 2710-2718. PMID:23343631

5. Dolan C, Moriarty RD, Lestinia E, Devocelle M, Forster RJ, Keyes TE. Cell uptake and cytotoxicity of a novel cyclometalated iridium(III) complex and its octaarginine peptide conjugate. J Inorg Biochem. 2013, 119, 65–74. PMID:23201851

6. O'Mahony AM, Desgranges S, Ogier J, Quinlan A, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM. In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery. Pharm Res. 2013, 30(4), 1086-1098.  PMID:23192687

7. Devocelle M. Targeted antimicrobial peptides. Front. Immun., 2012, 3:309. doi: 10.3389/fimmu.2012.00309. Epub 2012. PMID:23060887

8. O’Mahony, A. M. Godinho, B. M. C., Ogier, J, Devocelle, M, Darcy, R. Cryan, J. F., O’Driscoll, C. M. Click-Modified Cyclodextrins as Nonviral Vectors for Neuronal siRNA Delivery. ACS Chemical Neuroscience, 2012, 17, 744-752.  PMID:23077718

9. Bernard E, Buckley V, Moman E, Coleman L, Meade G, Kenny D, Devocelle M. Inhibition of platelet adhesion by peptidomimetics mimicking the interactive ß-hairpin of glycoprotein Iba.
Bioorg Med Chem Lett., 2012, 1, 3323-3326. PMID:22460035

10. Fitzgerald-Hughes D, Devocelle M, Humphreys H. Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives. FEMS Immunol Med Microbiol., 2012, 65, 399-412. PMID:22409572

11. Desgranges S, Ruddle CC, Burke LP, McFadden TM, O’Brien JE, Fitzgerald-Hughes D, Humphreys H, Smyth TP, Devocelle M.
b-Lactam-host defence peptide conjugates as antibiotic prodrug candidates targeting resistant bacteria. RSC Adv., 2012, 2, 2480-2492. DOI: 10.1039/c2ra01351g  

12. Bonnet CS, Devocelle M, Gunnlaugsson T. Luminescent lanthanide-binding peptides: sensitising the excited states of Eu(iii) and Tb(iii) with a 1,8-naphthalimide-based antenna. Org Biomol Chem., 2012, 10, 126-133. PMID:22038321

13. Kennedy DA, Vembu N, Fronczek FR, Devocelle M. Synthesis of Mutual Azo Prodrugs of Anti-inflammatory Agents and Peptides Facilitated by a-Aminoisobutyric Acid. J Org Chem., 2011, 76, 9641-9647. PMID:22026631   

14. Walsh EJ, Maher S, Devocelle M, O'Brien PJ, Baird AW, Brayden DJ. High Content Analysis to Determine Cytotoxicity of the Antimicrobial Peptide, Melittin and Selected Structural Analogues Peptides.  Peptides, 2011, 32, 1764-1773.  PMID:21703316

15. Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M. In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase. Antimicrob Agents Chemother. 2011, 55(5), 2487-2489. PMID:21343449

16. Laussmann MA, Passante E, Düssmann H, Rauen JA, Würstle ML, Delgado ME, Devocelle M, Prehn JH, Rehm M. Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8. Cell Death Differ. 2011, 18(10), 1584-1597. PMID:21455219

17. Duffy FJ, Verniere M, Devocelle M, Bernard E, Shields DC, Chubb AJ. CycloPs: Generating Virtual Libraries of Cyclized and Constrained Peptides Including Nonnatural Amino Acids. J Chem Inf Model. 2011, 51(4), 829-836. PMID:21434641

18. Concannon CG, Tuffy LP, Weisová P, Bonner HP, Dávila D, Bonner C, Devocelle M, Strasser A, Ward MW, Prehn JH. AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol., 2010, 5, 83-94.  PMID:20351066

19. Murphy J, Walshe R; Devocelle M. A Theoretical Analysis of the Pro-Drug Delivery System for Treating Antibiotic-Resistant Bacteria. IEEE/ACM Trans Comput Biol Bioinform., 2010, 15, 650-658. PMID:20644237

20. Maher S, Devocelle M, Ryan S,  McClean S, Brayden D. Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promotor, melittin. International Journal of Pharmaceutics., 2010, 15, 154-160. PMID:20025949

21. Cosgrave L, Devocelle M, Forster RJ, Keyes TE. Multimodal Cell Imaging by Ruthenium Polypryridyl Labelled Cell Penetrating Peptides. Chem. Commun., 2010, 7, 103-105. PMID:20024307

22. Flanagan L, Sebastià J, Tuffy LP, Spring A, Lichawska A, Devocelle M, Prehn JH, Rehm M. XIAP impairs Smac release from the mitochondria during apoptosis. Cell Death Dis. 2010, 1(6):e49. PMID:21364655

23. Brennan MP, Loughman A, Devocelle M, Arasu S, Chubb AJ, Foster, TJ, Cox D. Elucidating the role of S. epidermidis serine-aspartate repeat protein G (SdrG) in platelet activation. Journal of Thrombosis and Haemostasis.,  2009, 7, 1364-1372. PMID:19486275

24. Bernard E, Parthasarathi L, Cho MK, Aylward K, Raab M, Daxecker H, O'Dushlaine CT, Shields DC, Devocelle M, Keyes T, Cosgrave L, O'Neill S, Mok KH, Moran N. Ligand Switching in Cell-Permeable Peptides: Manipulation of the alpha-Integrin Signature Motif. ACS Chem Biol., 2009, 4, 457-471. PMID:19371094

25. Weisova P, Concannon C, Devocelle M, Prehn J, Ward M. Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons. J Neurosci., 2009, 29, 2997-3008. PMID:19261894

26. Pellegrin Y, Neugebauer U, Devocelle M, Forster RJ, Moran N, Kenny D, Keyes TE. Ruthenium Polypyridyl Peptide Conjugates: Membrane Permeable Probes for Cellular Imaging. Chem Commun., 2008, 5307-5309. PMID:18985192

27. Bonnet CS, Devocelle M, Gunnlaugsson T. Novel binuclear lanthanide luminescent peptide conjugates: Structural analysis in aqueous solution of potential metallo enzymatic mimics. Chem Commun., 2008, 4552-4554. PMID:18815680 

28. Murphy J, Walshe R, Devocelle M. A Computational Model of Antibiotic-Resistance Mechanisms in Methicillin-Resistant Staphylococcus aureus (MRSA). J Theor Biol., 2008, 254, 284-293.  PMID:18577389

29. Edwards RJ, Moran N, Devocelle M, Kiernan A, Meade G, Signac W, Foy M, Park SDE, Dunne E, Kenny D, Shields DC. Bioinformatic discovery of novel bioactive peptides. Nature  Chem Biol., 2007, 3, 108-112.  PMID:17220901

30. Daxecker H, Raab M, Bernard E, Devocelle M, Treumann A, Moran N. A peptide affinity column for the identification of integrin ?IIb-binding proteins. Anal Biochem. 2007, 374(1), 203-212. PMID:18082615

31. Aylward K, Ahrens,I, Devocelle M, Moran N. A novel functional role for the highly conserved [[alpha]]-subunit KVGFFKR motif in regulating integrin [[alpha]]IIb[[beta]]3-mediated cytoskeletal reorganization. J Thromb Haemost.,  2006, 4, 1804-1812.  PMID:16879224

32. Cryan SA, Devocelle M, Moran PJ, Hickey AJ, Kelly JG . Increased intracellular targeting to airway cells using octaarginine-coated liposomes: in vitro assessment of their suitability for inhalation. Mol Pharm., 2006, 3, 104-112.  PMID:16579639

33. Parthasarathi L, Devocelle M, Sondergaard C, Baran I, O'Dushlaine C, Davey N, Edwards R, Moran N, Kenny D, Shields D. Absolute net charge and the biological activity of oligopeptides. J Chem Inf Model. 2006, 46, 2183-2190. PMID:16995748

34. Lee J, Chubb AJ, Moman E, McLoughlin BM, Sharkey CT, Kelly JG, Nolan KB, Devocelle M, Fitzgerald DJ. Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the Prostaglandin H2 Synthase peroxidase activity. Org Biomol Chem., 2005, 3, 3678–3685.  PMID:16211102

35. Barr MP, Byrne AM, Duffy AM, Condron CM, Devocelle M, Harriott P, Bouchier-Hayes DJ, Harmey JH. A Peptide Corresponding to the Neuropilin-1 Binding Site Induces Apoptosis of Neuropilin-1 Expressing Breast Tumour Cells.  Br J Cancer. 2005, 92(2), 328-333. PMID:15655556 

36. Reilly D, Larkin D, Devocelle M, Fitzgerald DJ, Moran N. Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif. Platelets, 2004, 15(1), 43-54. PMID:14985176 

37. Dooley CM, Devocelle M, McLoughlin BM, Nolan KB, Fitzgerald DJ, Sharkey CT. A Novel Family of Hydroxamate based Acylating Inhibitors of Cyclooxygenase. Mol Pharm.,  2003, 63, 450-455.  PMID:12527817

38. Devocelle M, McLoughlin BM, Sharkey CT, Fitzgerald DJ, Nolan KB. A Convenient Parallel Synthesis of Low Molecular Weight Hydroxamic Acids Using Polymer-supported 1-Hydroxybenzotriazole. Org Biomol Chem. 2003, 1, 850 - 853

39. Loll PJ, Sharkey CT, O’Connor SJ, Dooley CM, O’Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ. O-Acetylsalicylhydroxamic acid, a Novel Acetylating Inhibitor of Prostaglandin H2 Synthase: Structural and Functional Characterization of Enzyme-Inhibitor Interactions. Mol Pharmacol. 2001, 60, 1407-1413.

Patents 
1.  Mortreux A, Agbossou F, Devocelle M, Dormoy J-R. Method for preparing optically active alpha-substituted benzylalcohols. PCT WO 98/11053 (19.03.98).

2  Cosgrave L, Devocelle M, Forster RJ, Kenny D, Moran N, Keyes TE, Pellegrin Y, ‘Ruthenium and Osmium Complexes for Peptide and Protein Functionalisation: Luminescence Intensity, lifetime and Resonce Raman Probes for Cellular Imaging', PCT WO2009/078000A2 (25.06.09).

3. Devocelle M, Kenny D, Foley V, Moman E. Peptidomimetics and uses thereof. PCT WO 2005/035568 (21.04.05).