Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Professor Mauro F. Adamo

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Professor Mauro F A Adamo MSc (Florence), PhD (Sheffield), MRSC, MACS, MPSI

Professor of Organic and Medicinal Chemistry, Royal College of Surgeons in Ireland (RCSI)
Tel :  +353-1-4022208.  Fax :  +353-1-4022168
email :


MSc (Cum Laude) in Pharmaceutical Chemistry & Technology, University of Florence, 1997
PhD (Sheffield) with Professor Varinder Aggarwal, 2001. 
Post-Doctoral Research Fellow, Dyson Perrin Laboratory, University of Oxford with Professor Sir Jack Baldwin 2001-2002

Lecturer in Chemistry, RCSI, 2002-2006
Senior Lecturer in Chemistry, RCSI, 2006-2010
Professor of Organic and Medicinal Chemistry, RCSI, 2010 - present

Representative Publications

1. Wells R, Moccia M, Adamo M.F. A. The preparation of 3-methyl-4-nitro-5-(2-alkylethenyl)isoxazoles. Tetrahedron Letters (2014), 55(4), 803-805.  

2. Alagha A, Moman E, Adamo, MFA, Nolan KB, Chubb AJ.  Design, synthesis and evaluation of aspirin analogues having an additional carboxylate substituent for antithrombotic activity [Erratum to document cited in CA151:336828] Bioorganic & Medicinal Chemistry Letters (2014), 24(1), 398

3. Illera DS, Surisetti S, Moccia M, Bellini G, Saviano M, Adamo MFA.  N-heterocyclic carbene catalysed homoenolate addition to 3-methyl-4-nitro-5-styrylisoxazoles, Tetrahedron Lett., 2012, 53,1808-1811.

4. Del Fiandra C, Piras L, Fini F, Disetti P, Moccia M, Adamo MFA.  Phase transfer catalyzed enantioselective cyclopropanation of 4-nitro-5-styrylisoxazoles. Chem. Commun.,  2012, 48,  3863-3865.

5. Moccia M, Fini F, Scagnetti M, Adamo MFA.  Catalytic Enantioselective Addition of Sodium Bisulfite to Chalcones., Angew. Chem., Int. Ed., 2011, 50, 6893-6895 

6. Adamo MFA, Bellini G, Surisetti S.  Two tandem sequential reactions catalyzed by [Au], N-heterocyclic carbenes (NHC) and organic bases. Tetrahedron, 2011, 67, 5784-5788

7. Bruschi S, Moccia M, Adamo MFA.  Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with  S-nucleophiles, Tetrahedron Lett., 2011, 52, 3602-3604

8. Giorgi G, Adamo MFA, Ponticelli F, Ventura A.  Synthesis, structural and conformational properties, and gas phase reactivity of 1,4-dihydropyridine ester and ketone derivatives. Org. Biomol. Chem., 2010, 8, 5339-5344

9.  Adamo MFA, Pergoli R, Moccia M.   Alkynyl-2-deoxy-d-riboses, a cornucopia for the generation of families of C-nucleosides., Tetrahedron, 2010, 66, 9242-9251

10. Fini F, Nagabelli M, Adamo MFA.  Development of a Mild Procedure for the Addition of Bisulfite to Electrophilic Olefins. Adv. Synth. Catal., 2010, 352, 3163-3168

11. Adamo MFA, Sarti-Fantoni P, Chimichi S, Sandrelli A. Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives, Tetrahedron Lett., 2010, 51, 6310-6312

12. Baschieri A, Bernardi L, Ricci A, Suresh S, Adamo MFA. Catalytic asymmetric conjugate addition of nitroalkanes to 4-nitro-styrylisoxazoles.  Angew. Chem. Int., Ed. 2009, 48, 9342-9345

13. Adamo MFA, Suresh S, Piras L..  Reaction of 5-(1-bromo-2-arylvinyl)-3-methyl-4-nitroisoxazoles and 1,3-dicarbonyl compounds. Tetrahedron, 2009, 65, 5402-5408

14. Adamo MFA, Disetti P, Piras L.  Preparation of functionalised monobactams from pyridones. Tetrahedron Lett., 2009, 50, 3580-3584. (50th anniversary special issue, invited contribution).

15. Adamo MFA, Suresh S.  Vinylogous nitroaldol (Henry) reaction using 3,5-diethyl-4-nitroisoxazole and carbonyl compounds.Tetrahedron, 2009, 65, 990-997

16. Adamo MFA, Nagabelli M.  Synthesis of homochiral dihydroxy-4-nitroisoxazolines via one-pot asymmetric dihydroxylation-reduction., Org. Lett., 2008, 10, 1807-1810

17. Adamo MFA, Brushi S, Suresh S, Piras L..  Aziridination of 3-methyl-4-nitro-5-styrylisoxazoles,
Tetrahedron Lett., 2008, 49, 7406–7409

18. Adamo MFA, Fusi S, Ponticelli F, Ventura A.  Rearrangement of 3,5-dicyano-1,4-dihydropyridines to densely functionalized cyclopentadienes, Tetrahedron Lett., 2008, 49, 5820-5822

19.  Adamo MFA, Konda VR.  A Multicomponent Synthesis of Cyclopropanes, Tetrahedron Lett., 2008, 49, 6224–6226

20. Adamo MFA , Pergoli R.  Synthesis and Medicinal properties of 2-Deoxyribose and ribose C-nucleosides. Curr. Org. Chem., 2008, 12 1544-1569

21. Adamo MFA, Nagabelli M.  Synthesis of homochiral dihydroxy-4-nitroisoxazolines via one-pot asymmetric dihydroxylation-reduction.  Org. Lett., 2008, 10, 1807-1810

22. Adamo MFA, Donati D, Sarti-Fantoni P, Buccioni A..   Practical route for N,O-heteroatom interchange in 3,5-disubstituted-4-nitroisoxazoles, Tetrahedron Lett., 2008, 49, 941-947

23. Adamo MFA, Brushi S.  Nitroso and Acylnitroso intermediates -  synthesis and applications in organic synthesis. Targets in Heterocycl. Chem., 2007, 11, 396-430

24. Adamo MFA , Pergoli R.  Studies on the generation of unnatural C-nucleosides using 1-alkynyl-2-deoxy-D-riboses. Org. Lett., 2007, 8, 4443-4446.

25. Adamo MFA, Konda VR, Donati D, Sarti-Fantoni P, Torroba T.  Three multicomponent reactions of 3,5-dimethyl-4-nitroisoxazole. Tetrahedron, 2007, 63, 9741-9745.

26. Adamo MFA, Nagabelli M.  Epoxidation of 3-methyl-4-N-acetyl-5-styryl isoxazoles. Tetrahedron Lett., 2007, 4703-4706.

27. Adamo MFA, Donati D, Duffy EF, Sarti-Fantoni P.  Modular synthesis of isoxazoleazepinones and pyrazoleazepinones. Tetrahedron, 2007, 63, 2684-2688

28. Adamo MFA, Brushi S. Generation of acylnitroso dienophiles: a study of metal catalysis. J. Org. Chem., 2007, 72, 2666-2669

29. Adamo MFA, Duffy EF, Konda VR, Murphy F.  An improved synthesis of 3-methyl-4-nitro-5-heteroarylethenylisoxazoles. Heterocycles, 2007, 71, 1173-1181

30.  Adamo MFA,  Konda VR.  Multicomponent synthesis of 3-indolepropionic acids. Org. Lett., 2007, 9, 303-305

31.  Donati D, Fusi S, Ponticelli F, Rossi Paccani R, Adamo MFA.  Photoreaction of some 5-alkylidene-2,5-dihydroisoxazoles: facile construction of novel unclassical ß-lactam containing heterocycles, Tetrahedron, 2007, 63, 1583-1588

32. Adamo MFA, Duffy EF. Multicomponent synthesisof 3-heteroarylpropionic acids. Org. Lett., 2006, 8, 5157-5159

33. Adamo MFA, Donati D, Duffy EF, Sarti-Fantoni P. Multicomponent synthesis of spiroisoxazolines,  J. Org. Chem., 2005, 70, 8395

34. Adamo MFA, Baldwin JE, Adlington RM. Application of bis-acetylenic ketones in synthesis: one pot preparation of the 1,2,4-triazepine and oxa-triaza-indenone cores. J. Org. Chem., 2005, 70, 3307-3308

35.  Adamo MFA, Adlington RM, Baldwin JE, Day AL.  A parallel synthesis approach towards a family of C-nucleosides, Tetrahedron, 2004, 60, 841-849 

36. Adamo MFA, Adlington RM, Baldwin JE, Prichard GL, Rathmell RE.  Practical routes to diacetylenic ketones and their application for the preparation of alkynyl substituted pyridines, pyrimidines and pyrazoles. Tetrahedron, 2003, 59, 2197-2205

37. Baldwin JE, Adlington RM, Wilkinson PJ, Marquez R, Adamo MFA. ,Studies towards the synthesis of Ginsenoyne-L; Efficient synthesis of 2’-epi-ginsenoyne.  Heterocycles, 2003, 59, 81-85.

38. Adamo MFA, Chimici S, Donati D, Sarti-Fantoni P.  The Structure of Triethylammonium 8-acetyl-9-phenyl-3-methyl-7-oxo-1-oxa-2-azaspiro[4.5]dec-2-ene-4-nitronate.  Acta Cryst, 2002, E58, o-1125-o1127 
39. Adamo MFA, Chimici S, De Sio F, Donati D, Sarti-Fantoni P.  The reactivity of 3-methyl-4-nitro-5-styrylisoxazole with some bis-enolisable ketones, Tetrahedron Lett., 2002, 4157-4160

40. Adamo MFA, Aggarwal VK, Sage MA.  Epoxidation of alkenes by amine catalyst precursors: Implication of aminium ion and radical cation intermediates. J. Am. Chem. Soc., 2000, 122, 8317-8318

41. Adamo MFA, Aggarwal VK, Sage MA.  An improved resolution of 2-methyl piperidine and its use in the synthesis of homochiral trans-2,6-dialkyl piperidines. Synthetic Comm., 1999, 29, 1747-1756


1. Process for the preparation of gamma amino acids and intermediates used in said process PCT Int. Appl. (2013), WO 2013076225 A1 20130530

2.  Adamo MFA, Aggarwal, V. K. Epoxidation Process using Amine Catalysts. Patent Number: 2000044735, 08-03-2000
3.  Adamo MFA, Nagabelli M. Method for Preparing Sulfur-Containing Compounds. Publication No: 20120029197, 02-02-2012
4.  Adamo MFA, Nagabelli M. Method for Preparing Sulfur-Containing Compounds. European Patent Application 08021530.4, 16.06.2010