Professor Celine J. Marmion

Professor Celine J. Marmion, BSc, PhD, PGCE, FRSC
Associate Professor of Bioinorganic Chemistry in the Department of Pharmaceutical & Medicinal Chemistry

email: cmarmion@rcsi.ie  Tel : +353 1 402 2161
 

Biography

BSc in Chemistry and Biology, University of Surrey, 1990.
PhD in Inorganic Chemistry, University of Surrey, 1994
PGCE, University of Kingston, 1996 
FRSC, 2013
FICI, 2015

Associate Professor of Chemistry, 2013 - present
Senior Lecturer in Chemistry, Royal College of Surgeons in Ireland, 2003-2013
Lecturer in Chemistry, Royal College of Surgeons in Ireland, 1997-2003
Lecturer in Chemistry, St. Mary's College, Strawberry Hill 1994-1995

Professional Committees

Royal Society of Chemistry

National Delegate on the Management Committee of COST15135, ‘Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig)' (2016-2020)
Steering Committee and National Delegate on the Management Committee of EU COST CM1105, 'Functional Metal Complexes that Bind to Biomolecules', 2011-2015
National Delegate on the Management Committee of EU COST D39, 'Metallodrug Design & Action', 2006-2011
Steering Committee and Grant Holder of COST D39 Management Committee, 2010-2011
Principal Investigator in the Centre for Synthesis and Chemical Biology (UCD/RCSI/TCD), 2002-present  

Research areas

Rational drug design, synthesis and pharmacological evaluation of metal-based anti-cancer agents
The role of hydroxamic acids in chemistry and biology and the structural diversity of their metal complexes

Awards

Recipient of an RCSI ‘IDEA's' Award (peer-reviewed for inventiveness, technology strength, market application, IP landscape and potential revenue generation by an international panel of experts in biotechnology, pharma, intellectual property and venture capital), 2010.
President's Teaching Award (as voted by students) for excellence in teaching, 2015
Inaugural RCSI President's Teaching Award (as voted by students) for excellence in teaching, 2009 

 

Selected Invited Lectures

‘Exploiting a Multi-Functional Approach Towards the Development of Novel Platinum and Copper-Based Anti-Cancer Chemotherapeutic Agents', 13th ISABC, NUI Galway, 13th June, 2015 (by invitation)

'Teaching an Old Drug New Tricks - Overcoming Drawbacks Associated with Classical Platinum Drugs as Anti-Cancer Agents', EuroBIC 12, University of Zurich, Switzerland, 27th Aug, 2014 (by invitation)

‘Teaching an Old Drug New Tricks - Developing Novel Multi-Functional Metallodrug Candidates Beyond Cisplatin', 2nd Symposium on Functional Metal Complexes that Bind to Biomolecules, University of Zurich, Switzerland, Aug, 2014

‘Teaching an Old Drug New Tricks - Overcoming Drawbacks Associated with Classical Platinum Drugs as Anti-Cancer Agents', RSC Bioinorganic Chemistry Award Half Day Symposium, UCD, 11th April, 2014 (by invitation)

‘Exploiting a Multi-Functional Approach Towards the Development of Novel Anti-Cancer Agents', 6th Meeting of the Irish Institute of Metal-Based Drugs, RCSI, Nov, 2013

‘Exploiting a Multi-Functional Approach Towards the Development of Novel Anti-Cancer Agents', COST CM1105 1st Symposium on Functional Metal Complexes that Bind to Biomolecules, University of Barcelona, Spain, Sept, 2013

‘Combating Cancer with Precious Metals - A Multi-Functional Approach towards better Anti-Cancer Agents', International Conference ‘Metallodrugs I: Design and Mechanism of Action', Olomouc, Czech Republic, Dec, 2012 

‘Combating Cancer with Precious Metals: Novel Bi-functional Platinum Drug Candidates with DNA Binding and Histone Deacetylase Inhibitory Activity', Gordon Research Conference ‘Metals in Medicine', June 27th - July 2nd, 2010, Proctor Academy, Andover, New Hampshire, USA. 

‘Exploiting Chromatin as a New Molecular Target for the Development of
Novel Metallochemotherapeutics', Symposium on Inorganic Chemistry in Ireland, Sept. 17th, 2010.

‘Exploiting New Molecular Targets Beyond DNA for the Development of Novel Cancer Metallochemotherapeutics', the 11th International Symposium on Bioinorganic Chemistry, Challenge for all Generations, Kudowa Zdrój, Poland, September 4th to 8th, 2010

‘Novel Multi-Functional Platinum Drug Candidates with DNA Binding and Histone Deacetylase Inhibitory Activity and with Enhanced Selectivity for Cancer Cells Over Normal Cells', 10th European Biological Inorganic Chemistry Conference (EUROBIC10), Thessaloniki, Greece, June 22nd-June 26th, 2010.

‘A Novel Platinum Drug Candidate with a Mechanism of Action and Cytotoxicity Profile Different to Classical Platinum Drugs', 10th International Symposium of Applied Bioinorganic Chemistry (10th ISABC), Debrecen, Hungary, Sept 2009.

‘Fighting Cancer with Precious Metals: New Metallodrug Candidates with Dual DNA Binding and Enzyme Inhibitory Properties', EU COST D39 Workshop, Debrecen, Hungary, Sept 2009

'Combating Cancer with Precious Metals', XVIIIth European Conference of GP2A, Sept 3rd-4th, TCD, 2009.

 

Representative Publications

1. Parker, J.P., Devocelle, M., Morgan, M.P., Marmion, CJ, ‘Derivatisation of buforin IIB, a cationic henicosapeptide, to afford its complexation to platinum(II) resulting in a novel platinum(II)-buforin IIb conjugate with anti-cancer activity', Dalton Trans., 2016, in press, DOI: 10.1039/C6DT01510G (Communication) 

2. Ude, Z., Romero-Canelón, I., Twamley, B., Fitzgerald Hughes, D., Sadler, P.J., Marmion, CJ, ‘A Novel Dual-Functioning Ruthenium(II)-Arene Complex of an Anti-microbial Ciprofloxacin Derivative - Anti-proliferative and Anti-microbial Activity', J. Inorg. Biochem., 2016, 160, 210-217 PMID: 26993079

3. Parker, J.P., Ude, Z., Marmion, CJ, Exploiting Developments in Nanotechnology for the Preferential Delivery of Platinum-Based Anti-Cancer Agents to Tumours: Targeting Some of the Hallmarks of Cancer, Metallomics, 2016, 8, 1, 43-60 by invitation PMID: 26567482- selected by the editor as a ‘hot article' and listed in the ‘Top 10 most accessed Metallomics articles from January - March 2016'

4. Parker JP, Devocelle M., Marmion CJ. Derivatisation of an Anti-Cancer Cationic Antimicrobial Peptide and its Complexation to Platinum(II). Zeitschrift für Anorganische und Allgemeine Chemie (ZAAC), 2013, submission by invitation for a Special Issue "Bioinorganic Chemistry: From Fundamental Research to Applications" of ZAAC, 2013, 639, 1628-1635

5. Parker JP, Nimir H, Griffith DM, Duff B, Chubb AJ, Brennan MP, Morgan MP, Egan DA,
Marmion CJ. A novel platinum complex of the histone deacetylase inhibitor belinostat: Rational design, development and in vitro cytotoxicity, J. Inorg. Biochem., 2013, 70-77 PMID: 23603796

6. Henari FZ, Gaynor D, Griffith DM, Mulcahy C, Marmion CJ. Non-linear optical
Measurement of Iron (III) Tris(pyridinehydroxamate) complexes. Chem. Phys. Letts., 2012, 552, 126-129

7. Brabec V, Griffith DM, Kisova A, Kostrhunova H, Lenka Z, Marmion CJ, Kasparkova J.  Valuable Insight into the Anti-Cancer Activity of the Platinum-Histone Deacetylase Inhibitor Conjugate, cis-Pt(NH₃)₂malSAHA_-2H)], Mol. Pharm., 2012, 9, 1990–1999, PMID: 22591133

8. Griffith DM, Duff B, Suponitsky KY, Kavanagh K, Morgan MP, Egan D, Marmion CJ.
Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity. J. Inorg. Biochem., 2011, 105, 793-799, PMID:21497577

9. Griffith DM, Szocs B, Keogh T, Suponitsky KY, Farkas E, Buglyó P, Marmion CJ.  Suberoylanilide hydroxamic acid, a potent histone deacetylast inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes, J Inorg Biochem. 2011, 22, 763-769,   PMID 21496451

10. Griffith DM, Parker J, Marmion CJ.  Enzyme inhibition as a key target for the development of novel metal-based anti-cancer therapeutics, Anti-Cancer Agents Med. Chem., 2010, 10, 354-370. PMID: 20380633 (Special Issue ‘Metal-Containing Drugs and Novel Coordination Complexes In Therapeutic Anticancer Applications', Invited Contribution).

11. Griffith DM, Haughey A, Chahal S, Müller-Bunz H, Marmion CJ. Novel palladium(II) and platinum(II) complexes of biocidal benzisothiazolinone (Bit); X-ray crystal structures of co-crystallised Bit/BitO, cis-Pd(en)(Bit_-1H)₂.H₂O, Inorg. Chim. Acta, 2010, 363, 2333-2337. DOI: 10.1016/j.ica.2010.02.005

12. Griffith D, Morgan MP, Marmion CJ. A Novel Anti-Cancer Bifunctional Platinum Drug Candidate with Dual DNA Binding and Histone Deacetylase Inhibitory Activity, Chem. Commun., 2009, 44, 6735-6737. PMID: 19885462 (Selected as a ‘Hot Article' by the Editor).

13. Griffith DM, Chopra A, Müller-Bunz H, Marmion CJ. The reduction of platinum(IV) and palladium(IV) ions by 2,6-pyridinedihydroxamic acid. Dalton Trans., 2008, 48, 6933-6939, PMID: 19050779.

14. Griffith D, Cecco S, Zangrando E, Bergamo A, Sava G, Marmion CJ. Ruthenium(III) dimethylsulfoxide pyridinehydroxamic acid complexes as potential anti-metastatic agents; synthesis, characterisation and in vitro pharmacological evaluation. J. Biol. Inorg. Chem., 2008, 13, 511-520. PMID: 18183430.

15. Griffith D, Krot K, Comiskey J, Nolan KB, Marmion CJ.  Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(III) and as nitric oxide donors; synthesis, speciation studies and nitric oxide releasing investigation, Dalton Trans., 2008,137-147, PMID: 18399240.

16. Griffith D, Bergamo A, Pin S, Vadori M, Müller-Bunz H, Sava G, Marmion CJ. Novel platinum pyridinehydroxamic acid complexes; synthesis, characterisation, X-ray crystallographic study and nitric oxide related properties, Polyhedron, 2007, 26, 4697-4706 (Special Issue - ‘Transition metal chemistry of NO, N₂O and related molecules', Invited Contribution), DOI: 10.1016/j.poly.2007.03.011

17. Mulcahy C, Krot KA, Griffith DM, Suponitsky KY, Starikova ZA, Marmion CJ.  Iron(III) tris(pyridinehydroxamate)s and related nickel and zinc complexes: platforms for the design of novel heterobimetallic supramolecular assemblies. Eur. J. Inorg. Chem., 2007, 1373-1380. DOI: 10.1002/ejic.200600758

18. Mulcahy C, Dolgushin FM, Krot KA, Griffith D, Marmion CJ. Synthesis, characterisation and speciation studies of heterobimetallic pyridinehydroxamate-bridged Pt(II)/M(II) complexes (M = Cu, Ni, Zn). Crystal structure of a novel heterobimetallic 3-pyridinehydroxamate-bridged Pt(II)/Cu(II) wave-like coordination polymer.  Dalton Trans., 2005, 1993-1998,  PMID: 15909049.

19. Griffith D,  Lyssenko K, Jensen P, Kruger PE, Marmion CJ. Novel platinum(II) hydroxamate and hydroximate complexes and the platinum-assisted hydrolysis of hydroxamic acids, Dalton Trans., 2005, 5, 956 – 961,  PMID: 15726150.

20. Marmion CJ, Griffith D, Nolan KB. Hydroxamic acids - an intriguing family of bioligands and enzyme inhibitors.  Eur. J. Inorg. Chem., 2004, 15, 3003-3016, DOI: 10.1002/ejic.200400221

21. Griffith D, Alessio E, Zangrando E, Marmion CJ.  A novel ruthenium nitrosyl complex which also contains a free NO donor moiety,  Inorg. Chim. Acta, 2004, 357, 3770-3774. DOI: 10.1016/j.ica.2004.05.004

22. Marmion CJ, Cameron B, Mulcahy C, Fricker SP. Ruthenium as an effective NO scavenger, Curr. Top. Med. Chem., 2004, 4, 1585-1603, PMID; 15579098

23. Marmion CJ, Murphy T, Nolan KB.  Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H₂O₂.   A remarkably simple model system for NO synthases, Chem. Commun., 2001, 18, 1870-1871. PMID: 12240355

24. Marmion CJ, Murphy T, Docherty JR, Nolan KB.  Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO mediated activation of guanylate cyclase by hydroxamic acids. Chem. Commun., 2000, 13, 1153-1154, DOI: 10.1039/B001631O

25. Marmion CJ, Murphy T, Starikova Z, Nolan KB.  fac-Tris(benzohydroxamato)iron(III) trihydrate, Acta Cryst., 2000, C56, E491-E492. DOI:10.1107/S010827010001307X

26. Hitchcock PB, Hughes DL, Larkworthy LF, Leigh GJ, Marmion CJ, Sanders JR, Smith GW, De Sousa JS.  New compounds containing the triangulo trichlorotrivanadium(II) moiety, J. Chem. Soc. Dalton Trans., 1997, 1127-1135, DOI:10.1039/A607225I

27. Choudhary N, Hughes DL, Kleinkes U, Larkworthy LF, Leigh GJ, Maiwald M, Marmion CJ, Sanders JR, Smith GW, Sudbrake C. New tetradentate Schiff bases, their oxovanadium(IV) complexes, and some complexes of bidentate Schiff bases with vanadium(III).  Polyhedron, 1997, 16, 1517-1528, ISSN: 0277-5387

28. Hughes DL, Larkworthy LF, Leigh GJ, McGarry (Marmion) CJ, Sanders JR, Smith GW, De Sousa JS. Trinuclear species in vanadium(II) chemistry, Chem. Commun., 1994, 2137 – 2138, DOI: 10.1039/C39940002137

Book Chapters  

1. Marmion C.J., Parker J.P. and Nolan K.B. Hydroxamic Acids: An Important Class of Metalloenzyme Inhibitors. In: Jan Reedijk and Kenneth Poeppelmeier, editors, Elsevier, Comprehensive Inorganic Chemistry II: From Elements to Applications, 2013, 3, 684-708 (by invitation).  

2. Griffith D, Devocelle M, Marmion CJ.  Hydroxamic Acids: Their Chemistry, Bioactivity, Solution and Solid Phase Synthesis  in  Amino Acids, Peptides and Proteins in Organic Chemistry, ed.Hughes AB, 2009, Volume 2,  pp. 93-137 (by invitation), ISBN: 978-3- 527-32098-1 

Patent

‘Compounds Having Dual Histone Deacetylase Inhibitory and DNA-Binding Activity’, European Patent Application No. 10742445.9, European Regional Phase of International Patent No: PCT/EP2010/060089, 15^th February, 2012