Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Professor Andreas Heise

                             

Professor Andreas Heise Dipl (Chem), PhD

Associate Professor of Chemistry and Head of Polymer Chemistry and Biopolymers Laboratory

Tel: +353-1-4025198

Email: andreasheise@rcsi.ie   

 

Biography

Andreas received his Ph.D. in Polymer Chemistry in 1997 from the University of Hannover, Germany. After a postdoc in a joint position at the IBM Almaden Research Center and Stanford University, he moved to DSM Research in The Netherlands where he held an industrial senior scientist position. In 2008, he accepted a full-time Science Foundation Ireland Stokes position at Dublin City University, Ireland, where he was head of the polymer research group. In addition, Andreas held an adjunct position at the School of Pharmacy in the Royal College of Surgeons in Ireland (from 2012). In 2015, Andreas accepted a full-time position at RCSI where he was promoted to Professor and became Head of Polymer Chemistry and Biopolymers Laboratory. Andreas is the principal co-ordinator for NeoGel, an EU FP7 consortium using hydrogels for biomedical applications. He is also joint co-ordinator for Translational Research in Nanomedical Devices (TREND) with Professor Sally-Ann Cryan. Andreas is also a key collaborator with CÚRAM, a Science Foundation Ireland research centre designing the next generation of ‘smart’ medical devices; NanoCap, providing research in polypeptide nanoparticles for drug delivery, and PoreSelect, supporting research in porous polymers for bioseparation. 

  

Research Interests

Synthetic polymer chemistry for the design of functional polymers

Control polymerization techniques to design biomaterials which can actively interact with the environment by biorecognition, while control release and imaging.

Bioresorbable polypeptides

Nanomedical materials such as polymer-modified nanoparticles and self-assembled structures with multiple functionalities and renewable polymers

Green polymer chemistry. 

 

Awards and Distinctions

DCU President’s Research Award in recognition of outstanding research achievements (2014).

Recognized by Enterprise Ireland as one of “Ireland’s Champions of Europe” for successfully securing significant FP7 funding as a project coordinator (2012).

Honorary Lectureship from the Royal College of Surgeons in Ireland (2012).

Member of the International Scientific Advisory Board of the Austrian Centre of Industrial Biotechnology (ACIB, 2011-). 

Member of the Managing Board of the Irish Separation Science Cluster (ISSC, 2010-2013)

DSM Industrial Publication Award: Macromolecules 2008, 41, 2439. “Functionalization of Polymers with High Precision by Dual Regio- and Stereoselective Enzymatic Reactions” (2009).

Science Foundation Ireland Stokes Lectureship (2008). 

 

Representative Publications (full publication list):

1.    M. Byrne, R. Murphy, A. Kapetanakis, J. Ramsey, S. A. Cryan, A. Heise. Star-Shaped Polypeptides: Synthesis and Opportunities for Delivery of Therapeutics. Macromol. Rapid Commun., 2015, 36, 1862-1876.

2.    Jacobs, J., Byrne, A., Gathergood, N., Keyes, T.E., Heuts, J.P.A., Heise, A. Facile synthesis of fluorescent latex nanoparticles with selective binding properties using amphiphilic glycosylated polypeptide surfactants. Macromolecules 2014, 47, 7303

3.    Ates, Z., Heise, A. Functional films from unsaturated poly(macrolactones) by thiol-ene cross-linking and functionalization. Polym Chem. 2014, 5, 2936.

4.    Bonduelle, C., Huang, J., Mena-Barragan, T., Ortiz Mellet, C., Decroocq, C., Etame, E., Heise, A., Compain, P., Lecommandoux, S. Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies. Chem. Commun. 2014, 50, 3350.

5.    Byrne, M., Victory, D., Hibbitts, A., Lanigan, M., Heise, A., Cryan, S.-A. Molecular weight and architectural dependence of well-defined star-shaped poly(lysine) as a gene delivery vector. Biomater. Sci. 2013, 1, 1223 (inside cover).

6.    Huang, J., Heise A. Stimuli responsive synthetic polypeptides derived from N-carboxyanhydride (NCA) polymerisation. Chem. Soc. Rev. 2013, 42, 7373.

7.    Borase, T., Ninjbadgar, T., Kapetanakis, A., Roche, S., O’Connor, R., Kerskens, C., Heise, A., Brougham, D.F. Stable aqueous dispersions of glycopeptide grafted magnetic nanoparticles of selectable functionality. Angew. Chem. Int. Ed Eng. 2013, 52, 3164-3167.

8.    Huang, J., Hastings, C.L., Duffy, G.P., Kelly, H.M., Raeburn, J., Adams, D.J., Heise, A. “Supramolecular Hydrogels with Reverse Thermal Gelation Properties from (Oligo)tyrosine Containing Block Copolymers. Biomacromolecules 2013, 14, 200-206.

9.    Audouin, F., Larragy, R., Fox, M., O’Connor, B., Heise A. Protein Immobilization onto Poly(acrylic acid) Functional Macroporous PolyHIPE Obtained by Surface-Initiated ARGET ATRP. Biomacromolecules 2012, 13, 3787.

10. Borase, T., Iacono, M., Ali, S.I., Thornton, P.D., Heise, A. Polypeptide Core-Shell Silica Nanoparticles with High Grafting Density by N-Carboxyanhydride (NCA) Ring Opening Polymerization as Responsive Materials and for Bioconjugation. Polym. Chem. 2012, 3, 1267 - 1275.

11. Huang, J., Bonduelle, C., Thévenot, J., Lecommandoux, S., Heise, A. Biologically Active Polymersomes from Amphiphilic Glycopeptide. J. Am. Chem. Soc. 2012, 134, 119.

12. Yeniad, B., Naik, H., Amir, R., Koning, C.E., Hawker, C.J., Heise, A. Encoded dendrimers with defined chiral composition via ‘click’ reaction of enantiopure building blocks. Chem. Commun. 2011, 47, 9870-9872.