Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Dr. James Barlow

 

Dr James Barlow BSc (Pharm), PhD, MPSI


Lecturer in Pharmacognosy
Associate Vice Dean for Student Affairs (2012-2016)
Programme Director for Assessment M.Pharm (2011-2014)

Tel +353 1 402 8520
email: jambarlow@rcsi.ie 

 

Biography

BSc in Pharmacy, Trinity College Dublin, 1997

PhD in Medicinal Chemistry under Dr. John Walsh, Department of Pharmacognosy, TCD, 2002

Pharmacist in Community Pharmacy 2002 - 2004

Lecturer in Pharmacognosy, RCSI, 2004-present

Professional Committees

IMB Herbal Medicines Sub-Committee


Research Interests

Synthesis of novel anti-tubulin anti-malarial compounds
Synthesis of novel polymer and lipid constructs
Herbal medicines and the regulation of herbal medicinal products


Representative Publications

1. Joanne M, Ramsey JM, Hibbitts A, Barlow J, Kelly C, Sivadas N, Cryan SA.  'Smart' non-viral delivery systems for targeted delivery of RNAi to the lungs.  Therapeutic Delivery 2013; 4(1); 59-76

2. Mara C, Dempsey E, Bell A, Barlow JW. Synthesis and evaluation of phenoxyoxazaphospholidine, phenoxyoxazaphosphinane, and benzodioxaphosphininamine sulfides and related compounds as potential anti-malarial agents. Bioorg. Med. Chem. Letts., Vol 23, Issue 12, 15 June 2013, Pages 3580-3583

3. Dempsey E, Prudêncio M, Fennell BJ, Gomes-Santos CS, Barlow JW, Bell A. Antimitotic herbicides bind to an unidentified site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites. Mol. Biochem. Parasitol., Volume 188, Issue 2, April 2013, Pages 116-127

4. K. Poh Loh, H. Ghorab, E. Clarke, R. Conroy, & J. Barlow.   Medical Students' Knowledge, Perceptions, and Interest in Complementary and Alternative Medicine.The Journal of Alternative and Complementary Medicine. April 2013, 19(4): 360-366 


5. Pabari RM, McDermott C, Barlow J, Ramtoola Z.  Stability of an Alternative Extemporaneous Captopril Fast-Dispersing Tablet Formulation Versus an Extemporaneous Oral Liquid Formulation. Clin. Ther, 2012, 34, 2221-2229.

6. Mara C, Dempsey E, Bell A,
Barlow JW. Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents. Bioorg. Med. Chem. Letts .,2011, 21,  6180-6183. 

7. Barlow JW, McHugh AP, Woods O, Walsh JJ. Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds.  Eur. J. Med. Chem., 2011, 46, 1545-1554.

8. Byrne AJ, Barlow JW, Walsh JJ. Synthesis and pharmacological evaluation of the individual stereoisomers of 3-[methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent. Bioorg. Med. Chem. Letts., 2011, 21, 1191-1194.

9. Hibbitts A, Lieggi N, McCabe O, Thomas W, Barlow JW, O’Brien F, Cryan S-A. Screening of siRNA nanoparticles for delivery to airway epithelial cells using high-content analysis. Therapeutic Delivery, 2011, 2, 987-999.

10. Barlow JW,  Zhang T, Woods O, Byrne AJ, Walsh JJ. Novel Mast Cell-Stabilising Amine Derivatives of 3,4-Dihydronaphthalen-1(2H)-one and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-5-one. Medicinal Chemistry, 2011, 7, 213-223.

11. Meyler L, Ramtoola Z, Barlow JW. Evaluation of the ability of pharmacy and medicine students to calculate drug dosage. Pharmacy Education, 2011, 11, 186 – 189. 

12. Barlow JW, Walsh JJ. Synthesis and evaluation of dimeric 1,2,3,4-Tetrahydro-naphthalenylamine and Indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity. Eur. J. Med. Chem., 2010, 45, 25-37.

13. Fennell BJ, Naughton JA, Barlow JW, Brennan G, Fairweather I, Hoey E, McFerran N, Trudgett A, Bell A. Microtubules as antiparasitic drug targets. Expert Opin. Drug Discov., 2008, 3, 501-518.

14. Barlow JW, Walsh JJ. Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds. Eur. J. Med. Chem., 2008, 43, 2891-2900.

15. Barlow JW, Strawbridge J. Teaching and assessment of an innovative and integrated pharmacy undergraduate module. Pharmacy Education, 2007, 7, 193 - 195.