Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Dr Zeibun Ramtoola

Dr. Zeibun Ramtoola BSc (Pharm), PhD, C.Dip.A.F.(ACCA), MPSI
Senior Lecturer in Pharmaceutics / Programme Director MSc Industrial Pharmaceutical Science [2010-2014]
Tel : +353 1 402 8626
Email: zramtoola@rcsi.com

Biography
Zeibun is a graduate in Pharmacy from Trinity College Dublin (TCD) and completed a PhD in Pharmaceutics in the Department of Pharmaceutics, TCD. She subsequently held a research fellowship for 3 years in the Pharmaceutics Department, TCD. She joined the Pharmaceutical industry in 1992 where she held numerous positions in the R & D and Strategic Management group. Zeibun joined the School of Pharmacy at RCSI in 2003 as a lecturer and was appointed senior lecturer in 2007.

Research Interests
Development of novel drug delivery technologies
Particle engineering for drug delivery and targeting
Solubility enhancement of poorly soluble therapeutic molecules
Non-invasive delivery of biotechnology drugs

Publications
24. Pabari R, Kelly J and Ramtoola Z. (2014). Disintegrating Crystalline Solid Dispersions Of Simvastatin For Incorporation Into Orodispersible Tablets. In press International Journal of Pharmaceutical Investigation.

23. Veeran Gowda V, Ritesh M Pabari R, ,Kelly J , Ramtoola Z (2014) Influence of Prosolv and Prosolv:Mannitol 200 direct compression fillers on the physicomechanical properties of atorvastatin oral dispersible tablets. In press Pharmaceutical Development and Technology

22. Sunderland T, Kelly J, Ramtoola Z (2013) Application of a novel 3-fluid nozzle spray drying process for the microencapsulation of therapeutic agents using incompatible drug-polymer solutions. In press Archives of Pharmacal Research

21. Mattu C, Pabari R, Boffito M, Sartori S, Ciardelli G, Ramtoola Z (2013) Comparative evaluation of novel biodegradable nanoparticles for the drug targeting to breast cancer cells. Eur J Pharm Biopharm 2013. 85: 463-472

20. Kirby BP*, Pabari R*, Chen CN, Al Baharna M, Walsh J, Ramtoola Z (2013) Comparative evaluation of the degree of pegylation of poly (lactic-co-glycolic acid) nanoparticles in enhancing central nervous system delivery of loperamide. J Pharm Pharmacol 2013 65(10):1473-81

19. Pabari R, Ryan B, Ahmed W, Ramtoola Z (2013) Physical and structural stability of the monoclonal antibody, trastuzumab (Herceptin®), intravenous solutions. Current Pharmaceutical Biotechnology;14(2):220-5 PMID:23360264 [PubMed]

18. Boland, K.; Concannon, C.; McCawley, N.; Kay, E. W.; McNamara D., Murray, F.E.; Ramtoola Z; Byrne, A.; Prehn, J. H. Targeting the 19S Proteasomal Subunit, Rpt4, in Colon Cancer Cells Induces Cell Death and Reduces Cellular Proliferation In Vitro and In Vivo, Gastroenterology, Volume 144, issue 5 (May, 2013), p. S-166-S-167. ISSN: 0016-5085 DOI: 10.1016/S0016-5085(13)60596-

17. Pabari R, McDermott C, Barlow J and Ramtoola Z (2012). Comparing the stability of an alternative extemporaneous captopril fast dispersible tablet and extemporaneous oral liquid formulation. Clinical Therapeutics, 2012. Nov;34(11):2221-9. doi: 10.1016, PMID: 23149007

16. Pabari R, Sunderland T, Ramtoola Z. Investigation of a novel 3-fluid nozzle spray drying technology for the engineering of multifunctional layered microparticles. Expert Opinion on Drug delivery, 9(12):1463-74 PMID: 23061546 [PubMed]

15. Pabari R and Ramtoola Z. Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets. International Journal of pharmaceutics. 2012; 430(1-2):18-25

14. Vijay K. Nandagiri, Clara Muttu, Jacqueline Daly, Zeibun Ramtoola, Gianluca Ciardelli, Franco Maria Montevecchi. Preparation and Characterization of Simvastatin Loaded PLGA Microparticles for Tissue Engineering Applications. Current Research in Pharmaceutical Sciences 2012; 02: 81-90

13. Pabari RM, Ramtoola Z. Effect of disintegration mechanism on wetting, water absorption, and disintegration time of orodispersible tablets. J Young Pharmacists 2012; 4:157-63

12. Myler, L, Ramtoola, Z and Barlow, J. Evaluation of the ability of pharmacy and medicine students to calculate drug dosage, Pharmacy Education, 2011; 11 (1): 186 - 189

11. Ritesh M. Pabari, Benedict Ryan, Catherine McCarthy and Zebunnissa Ramtoola. Effect of Microencapsulation Shear Stress on the Structural Integrity and Biological Activity of a Model Monoclonal Antibody, Trastuzumab. Pharmaceutics 2011, 3(3), 510-524

10. Vijay Kumar Nandagiri, Piergiorgio Gentile, Valeria Chiono, Chiara Tonda-Turo, Amos Matsiko, Zeibun Ramtoola, Franco Maria Montevecchi, Gianluca Ciardelli. Incorporation of PLGA nanoparticles into porous chitosan-gelatin scaffolds: influence on the physical properties and cell behavior. Journal of the mechanical behavior of biomedical materials 10/2011; 4(7):1318-27.

9. O'Donnell A. Baneham S., Pabari R., Kirby B.P., Ramtoola Z. (2011) Enhancing Cell Penetration using Surface modified Nanoparticles: Enhancing Drug Delivery to the Central Nervous System (CNS) J Pharm Pharmaceut Sci, 14(3) 207s-208s.

8. Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets. Ramtoola, Z., Lyons, P., Keohane, K., Kerrigan, S.W., Kirby, B.P., Kelly, JG. (2011) J. Pharm. Pharmacol., 63, 26-32.

7. Fluphenazine release from biodegradable microparticles: Characterization and modelling of release, Dunne M.M, Ramtoola Z, Corrigan O.I., J. Microencapsul, 2008 Sep 121-8.

6. A comparative study of a range of polymeric microspheres as potential carriers for the inhalation of proteins, Sivadas N; O'Rourke D.; Tobin A.; Buckley V.; Ramtoola Z.; Kelly J G; Hickey A J; Cryan SA; International journal of pharmaceutics 2008; 358(1-2):159-67.

5. Polydrug use in methadone patients in the Health Service Executive, Northern Area, Ramtoola, Z., Kirby, B. P., Zayed, N. (2006) Dublin. Irish Pharmacy Journal 84(8/9), 308-311.

4. Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate. A. Raoof, P. Chiu, Z. Ramtoola, I. K. Cumming, C. Teng, S. P. Weinbach, G. E. Hardee, A. Levin, R. Geary. J. Pharm. Sci., 2004, 93(6), 1431-1439.

3. Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-a-tocopheryl-poly (ethylene glycol 1000) succinate, V. Wacher, J. Silverman, S. Wong, P. Tran-Tau, A.O. Chan, A. Chai, X. Yu, D. O'Mahony and Z. Ramtoola. J. Pharmacol. Exp. Ther., 2002, 303(1), 308-313.

2. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. A. Raoof, Z. Ramtoola, B. McKenna, R. Z. Yu, G. Hardee, R. S. Geary. Eur. J. Pharm. Sci., 2002, 17(3), 131-138.

1.Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. M. Dunne, O. I. Corrigan and Z. Ramtoola, Biomaterials, 2000, 21(16),1659-1668