Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Prof. Steven W. Kerrigan

Steven Kerrigan 

Prof. Steven W. Kerrigan BSc (Hons), MSc, PhD, CBiol, FSB
Associate Professor in Pharmacology
Tel: +353 1 402 2104; Twitter: @SteveWKerrigan; Email: skerrigan@rcsi.com

Research Profile: http://pi.rcsi.ie/pi/skerrigan/

Biography

Prof. Steve Kerrigan is Associate Professor of Pharmacology in the School of Pharmacy in RCSI and Head of the Cardiovascular Infection Research Group which is part of the Irish Centre of Vascular Biology.

Prof. Steve Kerrigan is an honours graduate in B.Sc Pharmacology from King's College University of London, UK and obtained an M.Sc in Immunopharmacology from the University of Strathclyde, Glasgow, Scotland. He received a PhD in Cardiovascular Infection specifically investigating platelet-bacterial interactions from RCSI in 2001. Following this he carried out postdoctoral research in the University of California, San Francisco, USA. Prof. Kerrigan was appointed lecturer in Pharmacology in the School of Pharmacy in 2008, promoted to Senior Lecturer in 2013 and Associated Professor in 2017.

Since his faculty appointment, he has published over 60 articles in leading peer-reviewed international journals and filed 2 patent/disclosures and supervised 9 doctoral candidates to completion as primary supervisor. He has a current h-index of 23 (July 2017).  Accolades include a Health Research Board Training Fellowship (2008), Science Foundation Ireland Career Development Award (2013) and Enterprise Ireland Commercialization Fund (2017). He has presented over 50 invited talks at national and international universities, conferences and symposia including International Society for Thrombosis and Haemostasis and Platelets International Symposium. He has served as an invited reviewer for more than 40 scientific journals and served as a grant reviewer for various international funding bodies.  Prof. Kerrigan is a member of more than 10 international societies and was elected to Chartered status (CBiol) and Fellowship of the Society of Biology (FSB) which are the highest grades of membership of the professional body in 2013.

Professional Committees
Associate Editor Frontiers in Cellular and Infection Microbiology (2012-present)
3U DCU/NUI Maynooth/RCSI Partner Portal Development Committee (2012-present)
Member International Pharmaceutical Federation (FIP) Host Committee (2012-present)
Review Editor Frontiers in Pharmacotherapy of Inflammation (2009-present)
Council Member Royal Academy of Medicine in Ireland (2008-present)

Research Interests
- Investigating the role of the endothelium in the progression of severe bloodstream infection / sepsis.
- Establishing 3D in vitro models to study cardiovascular infection caused by Gram positive and Gram negative bacteria.
- Developing novel formulations to treat recurrence and persistence of infection in vivo.
- Visualisation of real time thrombus formation caused by invading pathogens using epifluorescent microscopy.
- Investigating the role of platelets as primitive immune cells in inflammation.

Publications
55. Garciarena C, McHale T, Martin-Loeches I, Kerrigan SW (2017) Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis. Critical Care In Press

54. Watkin R, Fitzpatrick GG, Kerrigan SW. 2017 The Evolving role of microRNAs in endothelial cell dysfunction following infection. Submitted Seminars in Thrombosis and Haemostasis. In Press

53. Haworth JA, Jenkinson HF, Petersen H, Beck CR, Brittan JL, Kerrigan SW, Nobbs AH. (2017) Concerted functions of Streptococcus gordonii surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix. Cellular Microbiolgy. 2017 Jan;19(1). doi: 10.1111/cmi.12667

52. McLoughlin A, Rochford K, McDonnell C, Kerrigan SW, Cummins P (2017) Staphylococcus aureus-mediated blood-brain barrier injury: An in vitro human brain microvascular endothelial cell model. Cellular Microbiology. Mar;19(3). doi: 10.1111/cmi.12664.

51. Kavanagh N, O'Brien FJ, Kerrigan SW (2017) The molecular mechanics of inflammatory bone disease caused by infection. In: Kon K, Rai M (eds) Microbiology of skin and soft tissue infections. Elsevier Publishers, Chpt 11, pp125-141 ISBN 978-012-81-1079-9

50. McDonnell C, Garciarena C, Watkin R, McHale T, McLoughlin A, Claes J, Verhamme P, Cummins P, Kerrigan SW. (2016) Inhibition of ?V?3 reduces Staphylococcus aureus-mediated endothelial cell dysregulation: implications for the treatment of sepsis. Journal of Thrombosis and Haemostasis Dec;14(12):2536-2547

49. Ryan AJ, Brougham CM, Garciarena CD, Kerrigan SW, O'Brien FJ (2016) Towards 3D models of studying Cardiovascular Disease. Drug Discovery Today 6446(16)30119-2

48. Watson C, Kerrigan SW, Cox D, Henderson I, Watson SP, Arman M. (2016) Human platelet activation by Escherichia coli: roles for FcgRIIa and integrin alphaIIb beta3. Platelets Sep;27(6):535-40

47. Garciarena C, McHale T, Watkin R, Kerrigan SW. (2015) Coordinated molecular cross-talk between Staphylococcus aureus, endothelial cells and platelets in bloodstream infection. Pathogens 4(4) 896-882

46. Kerrigan SW. (2015). Platelets as immune regulators in cardiovascular infection. In Kerrigan SW & Moran N (eds) The non-thrombotic role of platelets in health and disease. InTech Publishers, Chpt 4, pg65-84, ISBN 978-953-51-2208-1

45. O'Sullivan B, Kerrigan SW. (2015). Platelets, Inflammation and Respiratory Disease. In Kerrigan SW & Moran N (eds) The non-thrombotic role of platelets in health and disease. InTech Publishers, Chpt 7, pg137-158, ISBN 978-953-51-2208-1

44. Kerrigan SW, McDonnell C. (2015) Dysregulation of the endothelium following Staphylococcus aureus infection. Biochemical Society Transactions 43 (4):715-719 PMID: 26551718

43. Kerrigan SW, Poole AW. (2015) Focusing on the role of platelets in immune defence against invading pathogens. Platelets 26(4):285 PMID: 25910074

42. Claro, T, Kavanagh N, Foster TJ, O'Brien FJ, Kerrigan SW. (2015) Staphylococcus epidermidis serine-aspartate repeat protein G (SdrG) binds to osteoblast integrin alpha V beta 3. Microbes and Infection 17(6):695-401 PMID: 25749709

41. Berezin A, Zulli A, Kerrigan SW, Petrovic D, Kruzliak P. (2015) Predictive Role of Circulating Endothelial-derived Microparticles in Cardiovascular Diseases. Clinical Biochemistry 48(9):562-568 PMID: 25697107

40. Kerrigan SW. (2015) The expanding field of platelet-bacterial interconnections. Platelets, 26(4):293-301 PMID: 25734214

39. Moriarty R, McManus CA, Lambert M, Tilley T, Devocelle M, Brennan M, Kerrigan SW, Cox D. (2015) A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function. Thrombosis and Haemostasis 113(2):290-304 PMID: 25413489

38. Arman M, Krauel K, Tilley DO, Weber C, Cox D, Greinacher A, Kerrigan SW*, Watson SP*. (2014) Amplification of bacteria-induced platelet aggregation is triggered by FcgRIIa, integrin GPIIbIIIa and platelet factor 4. Blood. May 15;123(20):3166-74 * joint senior authors PMID: 24642751

37. Mitrugno A, Williams D, Kerrigan SW, Moran N. (2014) A novel and essential role for FcgRIIa in cancer cell induced platelet activation Blood Jan 9;123(2):249-60 PMID: 24258815

36. Keane C, Petersen H, Tilley T, Haworth J, Cox D, Jenkinson HF, Kerrigan SW. (2013) Multiple sites on Streptococcus gordonii surface protein PadA binds to platelet GPIIbIIIa Thrombosis and Haemostasis Nov;110(6):1278-87 PMID: 24136582

35. McGivern TJP, Molloy K, Baher M, McElvaney G, Moran N, Kerrigan SW. (2013) A platelet dense-granule secretion defect may lead to a muted inflammatory cell mobilization response in Cystic Fibrosis patients. Journal of Thrombosis and Haemostasis, Oct;11(10):1939-1942 PMID: 23941691

34. Tilley DO, Albert MA, Smolenski A, Cox D, O'Donnell JS, Douglas CWI, Watson SP, Kerrigan SW. (2013). Glycoprotein Ibalpha and FcgammaRIIa play key roles in platelet activation by the colonizing bacterium, Streptococcus oralis. Journal of Thrombosis and Haemostasis May11(5):941-950 PMID: 23413961

33. Tilley DO, Kerrigan SW. (2013) Platelet-bacterial interactions in the pathogenesis of infective endocarditis. Part I: The Streptococcus In: Kerrigan SW (ed) Recent Advances in Infective Endocarditis. InTech Publishers, Chpt 2, pg13-33, ISBN 978-953-51-1169-6 PMID: n/a

32. Kerrigan SW. (2013) Platelet-bacterial interactions in the pathogenesis of infective endocarditis. Part II: The Staphylococcus In: Kerrigan SW (ed) Recent Advances in Infective Endocarditis. InTech Publishers, Chpt 3, pg34-52, ISBN 978-953-51-1169-6 PMID: n/a

31. Claro T, Widaa A, McDonnell C, Foster TJ, O'Brien F, Kerrigan SW. (2013) Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor kappa B and IL6 production. Microbiology 2013 Jan;159(Pt 1):147-54 PMID: 23154968

30. Widaa A, Claro T, Foster TJ, O'Brien FJ, Kerrigan SW. (2012) Multiple signals induced by Staphylococcus Aureus Protein A results in bone loss and bone destruction PLoS ONE, 2012, July 7(7): e40586. PMID: 22792377
29. Kerrigan SW, Cox D (2012) Platelet-Bacterial Interactions as Therapeutic Targets in Infective Endocarditis. In: FR Breijo-Marquez (ed) Endocarditis. InTech Publishers Chpt 4, pg51-74 PMID: n/a

28. Kerrigan SW, Meehan N, Gallagher P. (2011) Obesity Management in the Pharmacy Pharmacy Education 2011; 11(1):130-131 PMID: n/a

27. Smith EJ, Visai L, Kerrigan SW, Speziale P Foster TJ. (2011) The Sbi protein: a multifunctional immune evasion factor of Staphylococcus Aureus Infection and Immunity. 2011 Sept;79(9):3801-9 PMID: 21708997

26. Cox D, Kerrigan SW, Watson SP. (2011) Platelets and the innate immune system: Mechanisms of bacterial induced platelet activation Journal of Thrombosis and Haemostasis June;9(6):1097-1107 PMID: 21435167

25. Claro T, Widaa A, O'Seaghdha M, Miajlovic H, Foster TJ, O'Brien FJ, Kerrigan SW (2011). Staphylococcus aureus protein A binds to osteoblasts and triggers signals that weaken bone in osteomyelitis PLoS ONE, 2011, April 15;6(4): e18748 PMID: 21525984

24. Kerrigan SW, Cox D. (2011) Biological mechanisms: Platelets and bacteria - current scientific evidence and methods of analyses in: LL. Haheim (ed) Oral Infections and Cardiovascular Disease. Betham Science Publishers. Chpt 6, pg 41-61 PMID: n/a

23. Ramtoola Z, Lyons P, Keohane K, Kerrigan SW, Kirby B, Kelly JG. (2011) Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets. Journal of Pharmacy and Pharmacology, January;63(1):26-32 PMID: 21155812

22. Keane C, Tilley T, Cunningham A, Smolenski A, Kadioglu A, Cox D, Jenkinson HF, Kerrigan SW. (2010) Invasive Sterptococcus pneumoniae triggers platelet activation via Toll Like Receptor 2 Journal of Thrombosis and Haemostasis, Dec;8(12):2757-65 PMID: 20946179

21. Keane C, Petersen H, Reynolds K, Newman D, Cox D, Jenkinson HF, Newman PJ, Kerrigan SW. (2010) Mechanism of outside-in alphaIIbbeta3-mediated activation of human platelets by the colonizing bacterium Streptococcus gordonii. Arteriosclerosis, Thrombosis and Vascular Biology, 2010, December;30(12):2408-15 PMID: 21071690

20. Kerrigan SW, Cox D. (2010) The effect of bacterial toxins on platelet function In: RM. Kini, KC. Clemtson, FS. Markland, MA McLane, T. Morita (eds) Toxins and Hemostasis: from Bench to Bedside. Springer Science-Verlag GmBH. Chpt 36 PMID: n/a

19. Miajlovic H, Zapotoczna M, Geoghegan JA, Kerrigan SW, Speziale P, Foster TJ. (2010) Direct interaction of iron regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets. Microbiology 2010 March:156(Pt3):920-928 PMID: 20007649

18. Kerrigan SW & Cox D. (2010) Platelet-bacterial Interactions Cellular and Molecular Life Sciences 2010 Feb;67:513-523 PMID: 20091082

17. Peterson H, Keane C, Jenkinson HF, Vickerman MM, Jesionowski A, Waterhouse J, Cox D, Kerrigan SW. (2010) Human platelets recognise a novel surface protein PadA on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa Infection and Immunity, 2010 Jan;78(1), 413-422 PMID: 19884334

16. Kerrigan SW & Cox D (2009). The Thrombotic Potential of Oral Pathogens Journal of Oral. Microbiology, 2009 Aug;1 24-35 PMID: 21523210

15. Tobin NP, Henehan GT, Murphy R, Atherton JC, Kerrigan SW, Cox D, Cahill P, Cummins PM (2008) Helicobacter pylori-Induced Inhibition of Vascular Endothelial Cell Functions: A Role for VacA-Dependent Nitric Oxide Reduction. American Journal Physiology Heart Circulatory Physiology 2008; Oct;295(4):H1403-13 PMID: 18660451

14. Kerrigan SW, Clarke N, Loughman A, Meade G, Foster TJ, Cox D. (2008) Molecular basis for Staphylococcus aureus-mediated aggregate formation under arterial shear in vitro Atherosclerosis Thrombosis and Vascular Biology, 28:335-340 PMID: 18063809

13. Kerrigan SW, Jakubovics NS, Keane C, Maguire PB, Wynne K, Jenkinson HF, Cox D. (2007) The role of Streptococcus gordonii surface proteins SspA/B and Hsa in platelet function. Infection and Immunity 2007 December; 75(12):5740-5747 PMID: 17893126

12. Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox D, Byrne MF. (2007) The effect of different strains of Helicobacter pylori on platelet aggregation. June; 21(6):367-370 PMID: 17571170

11. O'Seaghdha M, van Schooten CJ, Kerrigan SW, Emsley J, Silverman GJ, Cox D, Lenting PJ, Foster TJ. (2006) Staphylococcus aureus protein A binding to vonWillebrand factor A1 domain is mediated by conserved IgG binding regions. Federation of the Societies of Biochemistry and Molecular Biology Oct;273(21):4831-41 PMID: 16999823

10. Jacubovics N, Brittan JL, Kerrigan SW, Cox D, Stromberg N, Jenkinson HF. (2006) Interactions of mitis group streptococci with sialic acid receptors International Congress Series 1289:275 -289 PMID: n/a

9. Jakubovics N.S, Kerrigan SW, Nobbs A.H, Stromberg N, van Dolleweerd C.J, Kelly CG, Cox DM, Jenkinson HF. (2005) The functions of cell surface anchored antigen I/II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors Infection and Immunity October; 73(10):6629-6638 PMID: 16177339

8. Jakubovics NS, Brittan JL, Kerrigan SW, Cox D, Stromberg N, Jenkinson HF. (2005) Interactions of mitis group streptococci with sialic acid receptors. International Congress Series 2006 April; 1289:275-278 PMID: n/a

7. Plummer C, Wu H, Kerrigan SW, Meade G, Cox D, Douglas CWI. (2005) A serine rich glycoprotein of Streptococcus sanguis mediates adhesion to platelet GPIb. British Journal of Haematology 2005 April; 129(1):101-109 PMID: 15801962

6. Kerrigan SW, Gaur M, Murphy RP, Shattil SJ, Leavitt AD. (2004) Caspase-12: a developmental link between G-protein coupled receptors and integrin aIIbb3 activation Blood September; 104(5);1327-1334 PMID: 15059849

5. Byrne MF*, Kerrigan SW*, Atherton JC, Fitzgerald DJ., Murray FE, Cox D. (2003) Helicobacter pylori binds von Willebrand factor and interacts with GPIbĄ to induce platelet aggregation. Gastroenterology June; 124 (6);1846-1854 *joint first authors PMID: 12806618

4. Quinn M, Fullard J, Kerrigan SW, Cox D, Harriott P, Fitzgerald DJ. (2002) Characterization of a ligand-attenuated binding site on glycoprotein IIb/IIIa. Thrombosis and Haemostasis November; 88(5):811-816 PMID: 12428099

3. Eto K, Murphy R, Kerrigan SW, Bertoni A, Stuhlmann H, Nakano T, Leavitt AD Shattil SJ. (2002). Megakaryocytes from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proceedings of the National Academy of Sciences USA October; 99(20):12819-12824 PMID: 12239348

2. Kerrigan SW, Douglas I, Wray A, Heath, J, Byrne, M, Fitzgerald DJ, Cox D. (2002) A role for glycoprotein IbĄ in Streptococcus sanguis induced platelet aggregation. Blood July; 100(2):509-516 PMID: 12091342

1. O'Brein L*, Kerrigan SW*, Kaw G, Hogan M, Fitzgerald DJ, Foster T, Cox, D. (2002) Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: Roles for the clumping factors ClfA and ClfB and the serine-aspartate repeat protein SdrE. Molecular Microbiology May; 44(4):1033-1044 *joint first authors PMID: 12010496