Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Dr Fiona O'Brien

 Fiona O'Brien

Dr Fiona O'Brien BSc, MSc, PhD
Lecturer in Pharmaceutics / Year 2 Programme Lead - MPharm / Programme Director of the M.Sc in Industrial Pharmaceutical Sciences [2010-2014]
Tel: +353 1 402 8580

Fiona is a graduate of Science in University College Dublin and went on to complete an MSc in Medical Genetics in the University of Newcastle Upon Tyne, UK. She pursued her PhD research in gene therapy in the School of Pharmacy Trinity College Dublin. After completing her PhD she worked as Post-doctoral Research Fellow in Trinity College Dublin and for a number of years in the Pharmaceutical Industry. While in Industry she worked in the area of new and enhanced drug delivery technologies. Fiona was appointed lecturer in Pharmaceutics in the School of Pharmacy, Royal College of Surgeons in Ireland in 2006.

Research Interests
Targeted, non-viral gene delivery systems
Polymer and peptide based drug delivery systems

Selected Publications
Gill SL, O'Neill H, McCoy RJ, Logeswaran S, O'Brien F, Stanton A, Kelly H,
Duffy GP. Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model. Technol Health Care. 2014 Jan 1;22(1):37-51. doi: 10.3233/THC-130772. PubMed PMID: 24398813.

A DNA vaccination regime including protein boost and electroporation protects cattle against foot-and-mouth disease. V. Fowler, L. Robinson, B. Bankowski, S. Cox, S. Parida, C. Lawlor, D. Gibson, F. O'Brien, B. Ellefsen, D. Hannaman, H.-H. Takamatsu, P.V. Barnett. Antiviral Research 94, 2012, 25-34

Screening of siRNA Nanoparticles for Delivery to Airway Epithelial Cells Using High Content Analysis". Alan Hibbitts, Nora Lieggi, Olive McCabe, Warren Thomas, James Barlow, Fiona O'Brien, Sally-Ann Cryan. Therapeutic Delivery Vol. 2, No. 8, August 2011, Pages 987-999.

Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV. Niborski V, Li Y, Brennan F, Lane M, Torche AM, Redmond M, Bonneau M, Riffault S, Stirling C, Hutchings G, Takamatsu H, Barnett P, Charely B, Schwatrz-Cornil I, Vaccine, 24, 2006, 7204 - 7213.

Promoting the Oral Absorption of Drugs in Humans Using Gastro-Intestinal Permeation Enhancement Technology (GIPET). Thomas W. Leonard, Edel O'Toole, Fiona Brennan, and David J. Brayden, Drug Delivery Technology, February 2006, Vol 6 No 2, 40 - 47.

Influence of post-emulsification drying processes on the microencapsulation of Human Serum Albumin, Lane ME, Brennan FS, Corrigan OI, International Journal of Pharmaceutics, 307, (1), 2006, 16 - 22.

Comparison of post-emulsion freeze drying or spray drying processes for the microencapsulation of plasmid DNA, Lane ME, Brennan FS, Corrigan OI, Journal of Pharmacy and Pharmacology, 57, (7), 2005, 831 - 838.