Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Professor Brian Kirby

 

Professor Brian P. Kirby BSc(Pharm), PhD, MSc(LMD), Dip QC, MPSI
Interim Head of School / Associate Professor in Pharmacology
Tel: +353 1 402 5121
Email: bkirby@rcsi.com

Biography
Brian Kirby is a pharmacy graduate and scholar of Trinity College, Dublin and went on to complete a PhD in neuropharmacology with Prof G Shaw in TCD. Following this he undertook post-doctoral research in the University of Oxford, investigating novel treatments for Alzheimer's and Parkinson's diseases with Prof JNP Rawlins (Experimental Psychology) and Prof S Greenfield (Pharmacology).
He joined RCSI in 2003 and established the pharmacology teaching within the School of Pharmacy. In 2007, Prof Kirby was promoted to Senior Lecturer in Pharmacology within the School of Pharmacy and subsequently completed a Masters in leadership and management. Prof Kirby also has close links with the Addiction Services Department of the HSE and has worked in the areas of addiction treatment for many years.
In 2011, Prof Kirby was seconded to Kuala Lumpur, Malaysia as the foundation lead in clinical pharmacology in the new RCSI Medical School at Perdana University. While in Malaysia Prof Kirby contributed to the establishment of the new medical school and developed collaborative research with other research institutes in Malaysia. Prof Kirby returned from Malaysia in 2014 and was promoted to Associate Professor of Pharmacology in the RCSI School of Pharmacy in 2016.
In 2017, Prof Kirby was appointed as Adjunct Professor in the Faculty of Medicine and Health Sciences at Universiti Putra Malaysia, where he has significant research collaboration.
In October 2018, Prof Kirby was appointed the Interim Head of the RCSI School of Pharmacy.

Research Interests
Schizophrenia - Development of novel models for schizophrenia
Neurogenesis
The neural basis of learning and memory
Central drug delivery
Treatment of opiate dependence 

Publications
Careena S, Sani D, Tan SN, Lim CW, Hassan S, Norhafizah M, Kirby BP, Ideris A, Stanslas J, Basri HB, Lim CTS (2018) Effect of Edible Bird's Nest Extract on Lipopolysaccharide-Induced Impairment of Learning and Memory in Wistar Rats. Evidence-Based Complementary and Alternative Medicine, Volume 2018:1-7. DOI: 10.1155/2018/9318789.

Ren Z, Yan P, Zhu L, Yang H, Zhao Y, Kirby BP, Waddington JL, Zhen X (2018) Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation, Psychopharmacology (Berl). 235(1), 233-244.

Shearer JA, Douglas AS, Kirby BP, Tatlisumak T, Doyle KM (2017) Animal Models of Focal Cerebral Ischaemia and Haemorrhagic Transformation: Considerations in Experimental Stroke Study Design. Curr Vasc Pharmacol. Sep 5. doi: 10.2174/1570161115666170906115300. [Epub ahead of print].

Tan SF, Kirby BP, Stanslas J, Basri HB (2017) Characterisation, in-vitro and in-vivo evaluation of valproic acid-loaded nanoemulsion for improved brain bioavailability. J Pharm Pharmacol. 69(11), 1447-1457. 

Petit EI, Michalak Z, Cox R, O'Tuathaigh CM, Clarke N, Tighe O, Talbot K, Blake D, Joel J, Shaw A, Sheardown SA, Morrison AD, Wilson S, Shapland EM, Henshall DC, Kew JN, Kirby BP, Waddington JL (2017) Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes. Neuropsychopharmacology. 42(6), 1349-1360.

Tan SF, Masoumi HRF, Karjiban, RA, Stanslas J, Kirby, BP, Basri M, Basri HB (2016) Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability. Ultrasonics Sonochemistry 29, 299-308.

Kirby BP (2016) Animal Models of Psychotic Disorders: Dimensional Approach Modeling Negative Symptoms. In Modelling Psychopathological Dimensions of Schizophrenia (Eds Pletnikov M and Waddington J), Elsevier, pp 55-67.

Tan SL, Stanslas J, Basri M, Abedi Karjiban RA, Kirby B, Sani D, Basri HB (2015) Nanoemulsion-based parenteral drug delivery system of carbamazepine: Preparation, characterization, stability evaluation and blood-brain pharmacokinetics. Curr Drug Deliv. 12(6), 795-804.

Bailey, D.,Kirby, B.P. , Atkinson, J., Fixon-Owoo, S., Henman, M.C., Shaw, G.G., Doyle, K.M. (2015) Hydroxycinnamic acid amide derivatives of polyamine reverse spermine-induced CNS excitation. Pharmacol Biochem Behav. 133, 57-64.

Mathialagan, A., Nagalinggam, P., Mathialagan, S., Kirby, B.P. (2015) Relationship between performance barriers and pharmacist competency towards the implementation of an expanded public health pharmacy role. Int J Pharm Pract. 23(3), 320-326.

O'Donnell, A., Moollan, A., Baneham, S., Ozgul, M., Pabari, R.M., Cox, D., Kirby, B.P., Ramtoola, Z. (2015) Intranasal and intravenous administration of octa-arginine modified poly(lactic-co-glycolic acid) nanoparticles facilitates central nervous system delivery of loperamide. J Pharm Pharmacol. 67(4), 525-36.

Sani, D., Ramli, N., Kirby, B.P., Sumon, S., Basri, H., Stanslas, J. (2014) Andrographolide downregulates pro-inflammatory cytokines and free radical production to prevent dopaminergic neuro-degeneration induced by lipopolysaccharide. FASEB J, 28(1), 1143.16.

Bunk, E.C., König, H.-G., Prehn J.H., Kirby B.P. (2014) Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus. J Neurosci Res. 92(6), 679-91.

Kirby, B.P., Pabari, R., Chen, C.N., Al Baharna, M., Walsh, J., Ramtoola, Z. (2013) Comparative evaluation of the degree of pegylation of poly(lactic-co-glycolic acid) nanoparticles in enhancing central nervous system delivery of loperamide. J Pharm Pharmacol 65(10), 1473-81.

Solinsky C. & Kirby B.P. (2013) Medial prefrontal cortex lesions in mice do not impair effort-based decision making. Neuropharmacology, 65, 223-31.  

O'Tuathaigh C.M., Desbonnet L., Moran P.M., Kirby B.P., Waddington J.L. (2011) Molecular Genetic Models Related to Schizophrenia and Psychotic Illness: Heuristics and Challenges. Curr Top Behav Neurosci. 7, 87-119.

O'Donnell A. Baneham S., Pabari R., Kirby B.P., Ramtoola Z. (2011) Enhancing Cell Penetration using Surfacemodified Nanoparticles: Enhancing Drug Delivery to the Central Nervous System (CNS) J Pharm Pharmaceut Sci, 14(3) 207s-208s.

Ramtoola, Z., Lyons, P., Keohane, K., Kerrigan, S.W., Kirby, B.P., Kelly, JG. (2011) Investigation of the interaction of biodegradable micro- and nanoparticulate drug delivery systems with platelets J. Pharm. Pharmacol., 63, 26-32.

Bunk, E.C., Konig, H.-G., Bonner, H.P., Kirby, B.P., Prehn, J.H. (2010) NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: An in vitro model for the study of neural precursor cell proliferation. Brain Research, 1359, 22-32.

Kirby, B.P., Waddington, J.L., O'Tuathaigh, C.M. (2010) Advancing a functional genomics for schizophrenia: Psychopathological and cognitive phenotypes in mutants with gene disruption. Brain Res Bull. 83(3-4), 162-176.

O'Tuathaigh, C.M., Kirby, B.P., Moran, P.M., Waddington, J.L. (2010) Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia. Schizophr Bull. 36(2), 271-288.

Bunk, E.C., Konig, H.G., Bernas, T., Engel, T., Henshall, D.C., Kirby, B.P., Prehn, J.H.M (2010) BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death and Disease. 1, e15; doi:10.1038/cddis.2009.13.

Bunk E.C., Prehn J.H.M, Kirby B.P. (2009) Analysis of neuronal stem cell fate in an in vivo model of excitotoxic injury.  Irish Journal of Medical Science, Volume 178 Supplement 1, S11-S12.

Kennedy, M., O'Neill, S., Kirby, B.P. (2008) Water quality in the reconstitution of oral antibiotics.  Irish Pharmacy Journal, 86(Aug-Sept), 196-197.

Ramtoola, Z., Kirby, B. P., Zayed, N. (2006) Polydrug use in methadone patients in the Health Service Executive, Northern Area, Dublin. Irish Pharmacy Journal 84(8/9), 308-311.

Kirby, B. P. & Shaw, G. G. (2005) Effect of Spermine and N1-Dansyl-spermine on spontaneous epileptiform activity in the mouse cortical wedge preparation. Eur. J. Pharmacol. 524(1-3), 53-59.

Doyle, K. M.*, Kirby, B. P.*, Murphy, D., Shaw, G. G. (2005) Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo. Neurosci. Lett. 380(3), 247-251 * Joint first authorship.

Li, J., Henman, M. C., Doyle, K. M., Strbian, D., Kirby, B. P., Tatlisumak, T., Shaw G. G. (2004) The pre-ischaemic neuroprotective effect of a novel polyamine antagonist, N1-dansyl-spermine in a permanent focal cerebral ischaemia model in mice. Brain Res. 1029, 84-92.

Kirby, B. P. & Shaw, G. G. (2004) The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. Brain Res. 1011(1), 74-83.

Kirby, B. P., Ryder, S., Seiler, N., Renault, J., Shaw, G. G. (2004) N1-dansyl-spermine: a potent polyamine antagonist. Brain Res. 1011(1), 69-73.

Kirby, B. P. & Rawlins, J. N. P. (2003) The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behav. Brain Res. 143, 41-48.

Deacon, R. M. J., Bannerman, D. M., Kirby, B. P., Croucher, A., Rawlins, J. N. P. (2002) Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav. Brain Res., 133, 57-68.