Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Friday, 1st August 2008-RCSI Participates in Ground-breaking Schizophrenia Study Published in Nature

01 August 2008

Important new findings on the genetics of schizophrenia have just been published in the world’s leading scientific journal Nature under the auspices of the International Schizophrenia Consortium, which involves 74 scientists across Europe, USA and Australia. Prof. John Waddington, Molecular & Cellular Therapeutics, has enjoyed a long-standing collaboration with Dr. Aiden Corvin and Prof. Michael Gill, Neuropsychiatric Genetics Research Group, Trinity College Dublin. Dr. Corvin, Prof. Waddington and Prof. Gill and their colleagues are participants in this study under the leadership of Dr. Pamela Sklar of Harvard University.


Important new findings on the genetics of schizophrenia have just been published in the world’s leading scientific journal Nature.

Prof. Waddington said “Accumulation of the large number of subjects necessary for such studies [here, 3,391 patients and 3,181 controls] is achieved most readily by collaboration between individual research groups who pool their resources. The findings indicate that individuals with schizophrenia have a greater burden of structural variation among their genes. Further work will be needed to understand how these genetic variations result in abnormal brain cells, psychiatric symptoms and functional impairment”.