Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Dr. Marco P. Monopoli


Dr. Marco P Monopoli PhD
StAR Researcher Lecturer at the Department of Pharmaceutical & Medicinal Chemistry
email: Tel: +353-1-402 2760


Master Degree in Pharmaceutical Biotechnology in Universita' degli Studi di Modena and Reggio Emilia, 2004
PhD in the Applied Neurotherapeutics Research Group, School of Pharmacy, Conway Institute, University College Dublin, 2009
Post Doctoral fellow at the Centre for BioNano Interactions (CBNI), University College Dublin. 2009-2013
Principal Research Scientist at the Centre for BioNano Interactions (CBNI), University College Dublin. 2013-2015


Research Interests

Dr Marco Monopoli is StAR Research Lecturer in the department of Pharmaceutical and Medical Chemistry in the RCSI where he is estalbishing a multi-disciplinary centre focused on obtaining a complete understanding of the mechanisms of interaction between nanomaterials and living systems essential for Nanomedicine, Nanotoxiciolgy applications and to evaluate their Environmental Impact.
Dr Monopoli's studies have been focused in revealing the forces that govern bio-nano interactions and in understanding the biological implications of the protein corona.
Dr Monopoli has developed a variety of methods to isolate and characterise these nanoparticle protein corona complexes combining physico-chemical and proteomic techniques. Dr Monopoli is author of several high impact publications related to breakthroughs in the understanding and implications of the protein corona and further to this his work has been featured on the cover of Nature Nanotechnology (December 2012 Volume 7 No 12).

Representative Publications:

Wan S, Kelly PM, Mahon E, Stockmann H, Rudd P, Caruso F, Dawson KA, Yan Y, Monopoli MP*. The "Sweet" Side of the Protein Corona: Effects of Glycosylation on Nanoparticle-Cell Interactions. ACS Nano. 2015. First paper that highlights the role of glycosilation in the corona.
Monopoli MP, Aberg C, Salvati A, Dawson KA. Biomolecular coronas provide the biological identity of nanosized materials. Nature Nanotechnology. 2012;7:779-86. (388 citations; listed as top cited paper in the arena August 2013-2014 and therefore recongized as ‘Hot Paper' by Web of Science, Featured of Nature Nanotechnology cover December 2012).
Maiolo D, Bergese P, Mahon E, Dawson KA, Monopoli MP*. Surfactant Titration of the Nanoparticle-Protein Corona. Analytical Chemistry. 2014.?[4] Monopoli MP, Walczyk D, Campbell A, Elia G, Lynch I, Baldelli Bombelli F, et al. Physical-Chemical Aspects of Protein Corona: Relevance to in Vitro and in Vivo Biological Impacts of Nanoparticles. J Am Chem Soc. 2011;133:2525-34. (431 citations).
Salvati A, Pitek AS, Monopoli MP, Prapainop K, Bombelli FB, Hristov DR, Mahon E, Dawson KD. Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nature Nanotechnology. 2013;8:137-43. (288 citations. listed as top cited paper in the arena August 2013-2014 and therefore recongized as ‘Hot Paper' by Web of Science )


Awards and Distinctions

January 2016 StAR starting up funding;
April 2016 SFI industry fellowship