Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Dr Fiona O'Brien

 Fiona O'Brien

Dr Fiona O'Brien BSc, MSc, PhD
Senior Lecturer in Pharmaceutics
Year 2 Lead MPharm
Tel: +353 1 402 8580
Research Gate Profile:


Fiona is a graduate of Science in University College Dublin and went on to complete an MSc in Medical Genetics in the University of Newcastle Upon Tyne, UK. She pursued her PhD research in Gene Therapy in the School of Pharmacy, Trinity College Dublin. After completing her PhD, she worked as Post-doctoral Research Fellow in Trinity College Dublin and for a number of years in the Pharmaceutical Industry with Leo Pharma and Merrion Biopharma. While in Industry she worked in the area of new and enhanced drug delivery technologies and clinical trials. Fiona was appointed lecturer in Pharmaceutics in the School of Pharmacy, Royal College of Surgeons in Ireland in 2006 and was appointed Senior Lecturer in 2018. Since joining RCSI she has been the Programme Director of Studies on the MSc in Industrial Pharmaceutical Science and is currently the Year 2 Lead on the School of Pharmacy's MPharm programme. Her previous experience within pharmaceutical industry and in academia brings extensive knowledge of drug formulation development and delivery.

Her current research focuses on the design and development of medicines for paediatrics and the optimisation of off label use of medications to maximise clinical efficacy and safety in paediatric patients. She is a member of the European Paediatric Formulation Initiative and has collaborations nationally and internationally with Clinical and Industrial partners. She is currently collaborating with Our Lady's Children's Hospital Crumlin and the Rotunda Hospital in Dublin in the area of clinical Paediatric Pharmaceutics.

Research Interests
Investigation of medicines used off label in paediatric patients
Medication safety in neonates
Drug development and acceptability in paediatric patients

Selected Publications
Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine. Fiona O'Brien, David Clapham, Kamelia Krysiak, Hannah Batchelor, Peter Field, Grazia Caivano, Marisa Pertile, Anthony Nunn, Catherine Tuleu. May 2019. International Journal of Molecular Sciences 20(11). DOI: 10.3390/ijms20112688.

Compatibility of sildenafil citrate with noradrenaline and vasopressin during simulated y-site administration. Fiona O'Brien, Monnine Howlett, Cormac Bretnach, Helena Kelly, Fatemah Alsalman. February 2018. Archives of Disease in Childhood 103(2):e1.36-e1 DOI 10.1136/archdischild-2017-314584.41.

Methodologies for Assessing the Acceptability of Oral Formulations among Paediatric and Geriatric Patients: A Systematic Review. S. Ranmal, F. O'Brien, F. Lopez, F. Ruiz, M. Orlu, C. Tuleu, J. Walsh, F. Liu. Drug Discovery Today. 2018 DOI 10.1016/j.drudis.2018.01.038

siRNA-mediated targeting of the RNA-dependent RNA polymerase in the Norovirus genome. Rachel McCann, Sam McConkey, Fiona O'Brien. October 2015. BMC proceedings 9(Suppl 7):A11. DOI 10.1186/1753-6561-9-S7-A11.

Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model. Gill SL, O'Neill H, McCoy RJ, Logeswaran S, O'Brien F, Stanton A, Kelly H, Duffy GP. Technol Health Care. 2014 Jan 1;22(1):37-51. DOI 10.3233/THC-130772. PubMed PMID: 24398813.

A DNA vaccination regime including protein boost and electroporation protects cattle against foot-and-mouth disease. V. Fowler, L. Robinson, B. Bankowski, S. Cox, S. Parida, C. Lawlor, D. Gibson, F. O'Brien, B. Ellefsen, D. Hannaman, H.-H. Takamatsu, P.V. Barnett. Antiviral Research 94, 2012, 25-34.

Screening of siRNA Nanoparticles for Delivery to Airway Epithelial Cells Using High Content Analysis". Alan Hibbitts, Nora Lieggi, Olive McCabe, Warren Thomas, James Barlow, Fiona O'Brien, Sally-Ann Cryan. Therapeutic Delivery Vol. 2, No. 8, August 2011, Pages 987-999.

Efficacy of particle-based DNA delivery for vaccination of sheep against FMDV. Niborski V, Li Y, Brennan F, Lane M, Torche AM, Redmond M, Bonneau M, Riffault S, Stirling C, Hutchings G, Takamatsu H, Barnett P, Charely B, Schwatrz-Cornil I, Vaccine, 24, 2006, 7204 - 7213.

Promoting the Oral Absorption of Drugs in Humans Using Gastro-Intestinal Permeation Enhancement Technology (GIPET). Thomas W. Leonard, Edel O'Toole, Fiona Brennan, and David J. Brayden, Drug Delivery Technology, February 2006, Vol 6 No 2, 40 - 47.

Influence of post-emulsification drying processes on the microencapsulation of Human Serum Albumin, Lane ME, Brennan FS, Corrigan OI, International Journal of Pharmaceutics, 307, (1), 2006, 16 - 22.

Comparison of post-emulsion freeze drying or spray drying processes for the microencapsulation of plasmid DNA, Lane ME, Brennan FS, Corrigan OI, Journal of Pharmacy and Pharmacology, 57, (7), 2005, 831 - 838.