- Student Life
- Faculties & Departments
- Faculty of Medicine & Health Sciences
- School of Medicine
- School of Pharmacy
- School of Physiotherapy
- School of Nursing & Midwifery
- School of Postgraduate Studies
- Institute of Leadership
- Student, Academic & Regulatory Affairs
- Health Professions Education Centre (HPEC)
- Academic Departments
- Faculty of Nursing & Midwifery
- Faculty of Sports and Exercise Medicine
- Faculty of Dentistry
- Faculty of Radiologists
- Surgical Affairs
- Research News & Events
- Research Areas
- Principal Investigators
- Research Networks & Centres
- Technology Cores & Research Facilities
- Research Office
- Employment and Studentship Opportunities
- Research Ethics
- Technology Transfer Office & Management of Intellectual Property
- Research by Faculty
- Research by Academic Department
- Research by School
- Human Resources Strategy for Researchers (HRS4R)
- About RCSI
- CEO & Senior Management
- Annual Report
- 3U Partnership
- Contact Us & Location
- Venue Hire
- RCSI and the wider community
- Quality Enhancement Office
- Academic Health Centre
- RCSI Corporate Videos
- Freedom of Information (FOI)
- Class of 2013 Commemorative Video
- Faculty of Medicine & Health Sciences Strategy 2013 - 2017
- RCSI International
RCSI scientists discover new method of predicting response to chemotherapy in bowel cancer
Study published in ‘Cancer Research'
Scientists at the Royal College of Surgeons in Ireland (RCSI) and Beaumont Hospital have developed a new method of predicting which patients with bowel (colorectal) cancer will respond effectively to chemotherapy. The results of this study are published in the current issue of the prestigious Cancer Research journal.
The discovery could, in the future, help identify individuals who will not respond to chemotherapy, before they commence treatment, and may therefore require additional therapies. The new tool measures the amount of drug required for a cancer cell to die without harming healthy tissue. This prediction tool may also be used in clinical trails to develop new drugs to treat bowel cancer.
Commenting on the results, lead researcher, Professor Jochen Prehn, Director of the Centre for Systems Medicine at RCSI said: "Our study has enabled us to predict which patients are likely to be resistant to chemotherapy by examining how certain proteins in their cancer cells interact. We hope that the clinical decision-making tool that we have designed will enable doctors to develop personalised therapies for patients to ensure the best outcomes and potentially avoiding unnecessary chemotherapy and the negative side effects that go with it."
Professor Jochen Prehn, Director of the Centre for Systems Medicine at RCSI
Chemotherapy destroys cancer cells by bringing on a process of programmed cell death, known as apoptosis. However, sometimes mutations in cancer cells alter the levels of certain proteins and prevent this process of cell death occurring which results in chemotherapy being ineffective in some individuals with bowel cancer. In other patients, mutations in cancer cells have the opposite effect and promote the destruction of the cancer cells.
"The prediction tool also has the potential to be used in clinical trials so that new drugs can be developed for bowel cancer patients who are resistant to chemotherapy. The model we developed in this study could eventually be applied in other cancers." Professor Prehn concluded.
The first author on the study is Andreas Lindner, a PhD researcher who carried out the research with Professor Prehn and RCSI colleagues (Dr. Caoimhin Concannon, Dr. Gerhardt Boukes, Dr. Suzanne Hector, Dr. Heinrich Huber) in collaboration with clinicians (Deborah Ryan, Mary Cannon, Karen Boland, Ms. Deborah McNamara, Professor Elaine Kay, Prof Frank Murray) and research nurse Joan Kehoe at Beaumont Hospital, Dublin, and collaborators at St. Jude's Children's Research Hospital, Memphis, Tennessee (Dr Fabien Llambi and Professor Douglas Green).
Bowel cancer is the second most common cancer in Ireland. In 2009, 2,271 people were diagnosed with the disease. It is also the second most common cause of cancer death in Ireland. (1)
The research was funded by grants from the Health Research Board, Science Foundation Ireland, European Union FP7 and a Higher Education Authority PRTLI Cycle 4- Clinician Scientist Fellowship Award.
(1) Source: Irish Cancer Society