- Study With Us
- Student Life
- Faculties & Departments
- Faculty of Medicine & Health Sciences
- School of Medicine
- School of Pharmacy
- School of Physiotherapy
- School of Nursing & Midwifery
- School of Postgraduate Studies
- Institute of Leadership
- Student, Academic & Regulatory Affairs
- Health Professions Education Centre (HPEC)
- Academic Departments
- Faculty of Nursing & Midwifery
- Faculty of Sports and Exercise Medicine
- Faculty of Dentistry
- Faculty of Radiologists
- Surgical Affairs
- Research & Innovation
- Strategic Academic Recruitment Programme
- Research News & Events
- Research Areas
- Principal Investigators
- Research Networks & Centres
- Technology Cores & Research Facilities
- Research Office
- Employment Opportunities
- PhD Projects and Postgraduate Training Opportunities
- Research Ethics
- Technology Transfer Office & Management of Intellectual Property
- Research by Faculty
- Research by Academic Department
- Research by School
- Human Resources Strategy for Researchers (HRS4R)
- About RCSI
- CEO & Senior Management
- Annual Report
- 3U Partnership
- Contact Us & Location
- Venue Hire
- RCSI and the wider community
- Quality Enhancement Office
- Academic Health Centre
- RCSI Corporate Videos
- Freedom of Information (FOI)
- Faculty of Medicine & Health Sciences Strategy 2013 - 2017
- Medical Validation Ireland
- RCSI International
New RCSI research demonstrates how cannabis use during adolescence affects brain regions associated with schizophrenia
New research from the Royal College of Surgeons in Ireland (RCSI) published in Nature Publishing Groups Neuropsychopharmacology has shown physical changes to exist in specific brain areas implicated in schizophrenia following the use of cannabis during adolescence.
The COMT gene provides instructions for making enzymes which breakdown a specific chemical messenger called dopamine. Dopamine is a neurotransmitter that helps conduct signals from one nerve cell to another, particularly in the brains reward and pleasure centres. Adolescent cannabis use and its interaction with particular forms of the COMT gene have been shown to cause physical changes in the brain as well as increasing the risk of developing schizophrenia.
Dr Áine Behan, Department of Psychiatry, RCSI and lead author on the study said ‘This is the first study to show that the combined effects of the COMT gene with adolescent cannabis use cause physical changes in the brain regions associated with schizophrenia.. It demonstrates how genetic, developmental and environmental factors interact to modulate brain function in schizophrenia and supports previous behavioural research which has shown the COMT gene to influence the effects of adolescent cannabis use on schizophrenia-related behaviour's.'
The three areas of the brain assessed in this study were found to show changes in cell size, density and protein levels.
‘Increased knowledge on the effects of cannabis on the brain is critical to understanding youth mental health both in terms of psychological and psychiatric well-being,' Dr Behan continued.
The research was funded by the Health Research Board and Science Foundation Ireland.
Senior authors include Professor David Cotter and Professor Mary Cannon, Department of Psychiatry and Professor John Waddington, Department of Molecular and Cellular Therapeutics, RCSI. Additional authors in the study included Magdalena Hryniewiecka, Department of Psychiatry, RCSI, Dr Colm O'Tuathaigh and Dr Anthony Kinsella, Department of Molecular and Cellular Therapeutics, RCSI as well as collaborators Professor Maria Karayiorgou and Professor Joseph Gogos from the Department of Neuroscience, Columbia University, New York.