Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Professor Kevin B. Nolan

Staff Photo KBN 

Professor Kevin B. Nolan PhD, DSc(NUI), FRSC

(Retired 2013)

email: kbnolan@rcsi.ie  Tel: +353-1-4022155

 

Biography

BSc(NUI) in Chemistry, University College Galway,1969
PhD (NUI) in Inorganic Chemistry, University College Galway, 1972
DSc (NUI) for research in Bio-inorganic Chemistry, 2004

Post-doctoral Fellow, University of Stirling,1972-1973
Lecturer in Chemistry, University of Stirling, 1973-1974;  University College London, 1974-1975; University of Surrey, 1975-1987
Visiting Professor in Chemistry, University of California San Diego,1981-1982

Vice-dean of the RCSI Medical Faculty and Chairman of the RCSI Research Committee, 1997-2002

Recipient of NAIRTL National Award for Excellence in Teaching 2012
RCSI President's Teaching Award, 2012
RCSI Students' Union Award for best Pre-clinical Teacher, 1999

Author of 102 publications
Co-editor of Perspectives in Bioinorganic Chemistry, Vols 1-4 (JAI Press)
Chapter contributor (with Marmion CJ) on Hydroxamic Acids - an Important Class of Metalloenzyme Inhibitors in  ‘Comprehensive Inorganic Chemistry’, eds Reedijk J, Poeppelmeier K, Elsevier; in press Chapter contributor on ‘Chromium’ to Comprehensive Coordination Chemistry eds Wilkinson G, Gillard RD, McCleverty JA, (Pergamon, 1987) 
Chapter contributor on ‘Metal Complexes of Amino Acids, Peptides and Proteins’ in Royal Society of Chemistry Specialist Periodical Reports Amino Acids, Peptides and Proteins; Vols 15-27 ed Jones J

Have supervised 20 PhD and 5 MSc (by research) graduates

Chairman of the Royal Society of Chemistry, Ireland Section, 2003-2006
Management Committees of EU COST Action D8, D21, D34, 1996-2010
Co-founder and current Chairman of the Irish Institute for Metal- based Drugs

 

Research Interests

Bioinorganic, bioorganic and medicinal chemistry
Design and synthesis of hydroxamic acids as enzyme inhibitors and as structurally diverse bioligands
Synthesis of hydroxamic acid analogues of aspirin as inhibitors of cyclooxygenase
Hydroxamic acids as nitric oxide donors and as structurally diverse ligands 
Metal complexes as possible antitumour drugs


Selected Publications

1. Alagha A, Parthasarathi L, Gaynor D, Müller-Bunz H,  Starikova ZA, Farkas E, O’Brien EC, Gil MJ, Nolan KB.  Metal complexes of cyclic hydroxamates. Synthesis and crystal structures of  3-hydroxy-2- methyl- 3H-quinazolin-4-one (ChaH) and of its Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) complexes.  Inorg Chim Acta., 2011, 368, 58-66.  

2. Dorschner KV, Toomey D, Brennan MP, Heinemann T, Duffy FJ, Nolan KB, Cox D, Adamo MFA, Chubb AJ.  TIN - A Combinatorial Compound Collection of Synthetically Feasible Multicomponent Synthesis Products, J.  Chem. Inf. Model., 2011, 51, 986-995

3. Wangpradit O, Moman E, Nolan KB, Buettner GR, Luthe LWG. Observation of an unusually electronically distorted semiquinone radical of PCB metabolites in the
active site of prostaglandin H synthase-2. Chemosphere, 2010, 81, 1501-1508.

4. Alagha ABM, Gaynor D, Müller-Bunz H, Nolan KB,  Parthasarathi L.  
fac-Tris(4-aminobenzohydroxamato)iron(III) ethanol solvate., Acta Cryst, 2010, E66, m853-m854.

4. Griffith D, Krot K, Comiskey J, Nolan KB, Marmion CJ.  Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(III) and as nitric oxide donors: syntheses, speciation studies and nitric oxide releasing investigation. Dalton Trans., 2008, 137-147.

6. Krot K, Llamas-Saiz AL, Vembu N, Nolan KB.
The first crystal structures of mercury(II) complexes of tetra-amides (L1 and L2) and tetramethyl-amides (L3 and L4) of EDTA and PDTA. Formation of distorted octahedral and  distorted capped octahedral mercury(II) complexes and of a trinuclear complex containing HgCl2-bridged [Hg(L3)Cl]+ Moieties.  Zeit. für Anorg. Allg. Chem.,  2007, 633,1900–1910.

7. Chubb AJ, Fitzgerald DJ, Nolan KB, Moman E. The Productive Conformation of PGG2 at the Peroxidase Site of Prostaglandin Endoperoxide H Synthase. Biochemistry, 2006, 45, 811-820.

8. Krot KA, Danil de Namor AF, Aguilar-Cornejo A, Nolan KB.  Speciation, stability constants and structures of complexes of copper(II), nickel(II), silver(I) and mercury(II) with PAMAM dendrimer and related tetraamide ligands. Inorg Chim Acta, 2005, 358, 3497-3505.

9. Lee J, Chubb AJ, Moman E, McLoughlin BM, Sharkey CT, Kelly JG, Nolan KB, Fitzgerald DJ, Devocelle M.   Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the Prostaglandin H2 Synthase peroxidase activity. Org. Biomol. Chem., 2005, 3, 3678 – 3685.

10. Danil de Namor AF, Aguilar-Cornejo A, Soualhi R, Shehab M, Nolan KB, Ouazzani N, Mandi L.. Calix(4)arene Pyridine Derivative and Its Monomeric Component: Structural and Thermodynamic Aspects of Their Complexatio n with Metal Cations. J. Phys. Chem., 2005, 109, 14795 -14799.

11. Marmion CJ, Griffith D, Nolan KB.  Hydroxamic acids - an intriguing family of bioligands and enzyme inhibitors., Eur. J. Inorg. Chem., 2004, 15, 3003-3016.

12. Comiskey J, Farkas E, Krot-Lacina KA, Pritchard RG,  McAuliffe CA (the late), Nolan KB. Synthesis, structures and speciation studies of ruthenium(III)-hydroxamate/ hydroximato complexes. Crystal and molecular structure of hydrated [Ru(H2edta)(2 methoxyphenylhydroxamate)], the first structurally characterised ruthenium (III)-hydroxamate complex. Dalton Trans., 2003, 4243 - 4249.

13. Dooley CM, Devocelle M, McLoughlin B, Nolan KB, Fitzgerald DJ.  A novel family of hydroxamate based acylating inhibitors of cyclooxygenase. Mol. Pharmacol., 2003, 63, 450-455.

14. Devocelle M, McLoughlin BM, Sharkey CT, Fitzgerald DJ, Nolan KB.  A convenient parallel synthesis of low molecular weight hydroxamic acids using polymer-supported hydroxybenzotriazole. Org. Biomol. Chem., 2003, 1, 850 - 853.

15. Cornejo AA, Castineiras A, Yanovsky AI, Nolan KB. Gold(III) complexes of amides of EDTA (L, L1) and PDTA (L2, L3) as model systems for gold(III)-peptide/protein interactions. Synthesis of [AuLCl][AuCl4], [AuL2Cl]Cl and related complexes and the crystal and molecular structures of [Au(LH-1)Cl][AuCl4] containing a deprotonated amide ligand and of (LH2)2[AuCl4].3.5 [AuCl2]0.5.2H2O. , Inorg. Chim. Acta., 2003, 349, 91-96.

16. Gaynor D, Starikova ZA, Ostrovsky S, Haase W, Nolan KB. Synthesis and structure of a heptanuclear nickel(II) complex uniquely exhibiting four distinct binding modes, two of which are novel, for a hydroxamate ligand. , Chem. Commun., 2002, 506-507.

17. Marmion CJ, Murphy T, Nolan KB. Ruthenium(III) readily abstracts NO from L-arginine, the physiological precursor to NO, in the presence of H2O2. A remarkably simple model system for NO synthases, Chem. Commun., 2001, 1870-1871.

18. Gaynor D, Starikova ZA, Haase W, Nolan KB. Copper(II) complexes of isomeric aminophenylhydroxamic acids. A novel 'clam-like' dimeric metallacrown and polymeric helical structure containing interlinked unique copper(II) sites. Dalton Trans., 2001, 1578-1581.

19. Loll PJ, Sharkey CT,  O'Connor  SJ, Dooley CM, O'Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ. O-Acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H-2 -synthase: Structural and functional characterization of enzyme-inhibitor interactions. Mol. Pharmacol., 2001, 60, 1407-1413.

20. Jolley JN, Yanovsky AI, Kelland LR, Nolan KB.  Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substitutents. Crystal and molecular structure of [PtL4Cl2]•H2O where L4 is ethylenediamine-N,N' -diacetate. J. Inorg. Biochem., 2001, 83, 91-100.

21. Jolley JN, Cross WI, Pritchard RG, McAuliffe CA, Nolan KB.  Synthesis and characterisation of mercaptoimidazole, mercaptopyrimidine and mercaptopyridine complexes of platinum(II) and platinum(III). The crystal and molecular structures of tetra(2-mercaptobenzimidazole)- and tetra(2-mercaptoimidazole) platinum(II) chloride. Inorg. Chim. Acta., 2001, 315, 36-43.

22. Marmion CJ, Murphy T, Docherty JR, Nolan KB.  Hydroxamic acids are nitric oxide donors. Facile formation of ruthenium(II)-nitrosyls and NO-mediated activation of guanylate cyclase by hydroxamic acids. Chem. Commun., 2000, 1153-1154. 

For a full list of publications see:
https://research1.rcsi.ie/pi/kbnolan/pubs.asp