Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Professor Jochen Prehn

Jochen Prehn
 

Prof. Jocehn Prehn

Head, Chairman of Department-jprehn@rcsi.ie ,

Jochen Prehn has been Professor and Chairman, of the Department of Physiology and Medical Physics, at the RCSI since 2003. He was the first recipient of a Science Foundation Ireland Research Professorship award. During his career Prof. Prehn has been awarded research funding exceeding 10 million euro. He has published 123 peer reviewed papers and has been an invited speaker at over 70 conferences and workshops.

Prof. Prehn has been supervising undergraduates in physiology, pharmacology and neuroscience for over 15 years and also has given extensive lectures to medicine and pharmacy students.

Prof. Jochen Prehn leads a research group focusing on cell death mechanisms and their implication for human disease. Apoptosis is critical for the elimination of unwanted cells during development. Defects in apoptosis pathways have been implicated in neurodegenerative, ischemic, me and malignant disorders.
His group focuses on the Bcl-2 family of proteins which contain both pro- and anti-apoptotic proteins and regulate the mitochondrial pathway of apoptosis. The group investigates the role of BH3 only proteins in acute and chronic neurodegeneration, diabetes mellitus, and ER stress, as well as new target structures for the treatment of cancer, using both in vitro and in vivo models of human disease.

A second major research interest lies in real-time imaging of cell death signals in neurons and cancer cells, employing confocal GFP and FRET techniques., and their interaction with cellular bioenergetics. This research includes the development of computational approaches to understand and overcome apoptosis sensitivity and resistance and cellular bioenergetics at a systems level.

All Prof. Prehn's research interests and achievements to date  can be viewed on the research page.

 

In addition Prof. Prehn is the director of the Centre for the Study of Neurological Disorders (CSND)- www.rcsi.ie/csnd and the Centre for Systems Medicine CSM- www.SystemsMedicineIreland.ie .