Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Our research

DSC staff members conduct research in a range of health research areas, including:

  • Cancer
  • Cardiovascular disease
  • Health psychology
  • Health services research
  • Obstetrics and gynaecology
  • Overweight/obesity
  • Pharmacoepidemiology
  • Psychiatry
  • Public health

DSC staff members have particular methodological strengths in:

  • Design and analysis of randomised controlled trials
  • Design and analysis of observational studies
  • Causal inference and comparative effectiveness research
  • Clinical Prediction Rule development
  • Analysis of incomplete data
  • Analysis of 'omics' data (genomics, proteomics, transcriptomics)
  • Data integration
  • Multivariate statistics
  • Scale development
  • Systematic reviews and meta-analysis

Interest groups

The DSC coordinates a number of College-wide interest groups in specific methodological approaches, including:

Grants awarded (2016 - )

DSC researchers have collaborated on grant applications to all major funding bodies, including SFI, HRB, IRC, Wellcome Trust and EU H2020. Recent grants awarded include:

2017

  • Breast Cancer Now Catalyst Grant: ~€250,000; co-applicant.
  • Research Collaborative for Quality and Patient Safety (RCQPS) Award: ~€260,000; collaborator.

2016

  • RCSI Seed Fund Award: €50,000; co-applicant.
  • HRB Health Research Award: ~ €790,000; co-applicant

Publications (2016 - )

2017

  • Synnott NC, Bauer NR, Madden SF, Murray AM, Klinger R, O' Donovan N, O'Connor D, Gallagher WM, Crown J, Bauer AR, and Duffy MJ. Mutant p53 as a therapeutic target for the treatment of triple-negative breast bancer: Preclinical investigation with the anti-p53 Drug, PK11007. Cancer Lett. 2017 Oct 22. pii: S0304-3835(17)30622-5. [Epub ahead of print] PMID: 29069577.
  • Collins DM, Gately K, Hughes C, Edwards C, Davies A, Madden SF, O'Byrne KJ, O'Donovan N, Crown J. Tyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines. Cell Immunol. 2017 Sep;319:35-42. PMID: 28735814.
  • O'Shea J, Cremona M, Milewska M, Holmes F, Espina V, Liotta L, O'Shaughnessy J, Toomey S, Morgan C, Madden SF, Carr A, Elster N, Hennessy B. A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib. Oncotarget, in press.
  • Toomey S, Eustace AJ, Fay J, Sheehan KM, Carr A, Milewska M, Madden SF, Teiserskiene A, Kay EW, O’Donovan N, Gallagher W, Grogan L, Breathnach O, Walshe J, Kelly C, Moulton B, Kennedy MJ, Gullo G, Hill AD, Power C, Duke D, Hambly N, Crown J, Hennessy BT. Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies. Breast Cancer Res. 2017 Jul 27;19(1):87. PMID: 28750640.
  • Li B, Ní Chonghaile T, Fan Y, Madden SF, Klinger R, O'Connor AE, Walsh L, O'Hurley G, Mallya Udupi G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn SC, Jirstrom K, Caldas C, O'Connor D, Gallagher WM. Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer. Cancer Res. 2017 Jul 15;77(14):3834-3845. PMID: 28455421.
  • McDermott MSJ, Canonici A, Ivers L, Browne BC, Madden SF, O'Brien NA, Crown J, O'Donovan N. Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells. Int J Oncol. 2017 Jun;50(6):2221-2228. PMID: 28498399.
  • Madden SF, Connolly C, Buggy DJ, Gallagher HC. Expression of anaesthetic and analgesic drug target genes in excised breast tumour tissue: Association with clinical disease recurrence or metastasis. PLOS One. 2017 May 30;12(5):e0177105. PMID: 28558008.
  • Madden SF, Murray A, Synnott NC, Klinger R, O'Connor D, O'Donovan N, Gallagher W, Crown J, Duffy MJ. Vitamin D receptor as a target for breast cancer therapy. Endocr Relat Cancer. 2017 Apr;24(4):181-195. PMID: 28213567.
  • Rapetti-Mauss R, Bustos V, Thomas W, McBryan J, Harvey H, Lajczak N, Madden SF, Pellissier B, Borgese F, Soriani O, Harvey BJ. Bidirectional KCNQ1:ß-catenin interaction drives colorectal cancer cell differentiation. Proc Natl Acad Sci U S A. 2017 Apr 18; 114(16):4159-4164. PMID: 28373572. 
  • Lundon DJ, Boland A, Prencipe M, Hurley G, O'Neill A, Kay E, Aherne ST, Doolan P, Madden SF, Clynes M, Morrissey C, Fitzpatrick JM, Watson RW. The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation. BMC Cancer. 2017 Mar 1;17(1):163. PMID: 28249598.
  • Hayden JC, Dawkins I, Breatnach C, Leacy FP, Foxton J, Healy M, Cousins G, Gallagher PJ, Doherty DR. Effectiveness of a2 agonists for sedation in paediatric critical care: study protocol for a retrospective cohort observational study. BMJ Open. 2017 May 30;7(5):e013858. PMID: 28566361. 
  • Leacy FP, Floyd S, Yates TA, White IR. Analyses of sensitivity to the missing-at-random assumption using multiple imputation with delta adjustment: application to a tuberculosis/HIV prevalence survey with incomplete HIV-status data. Am J Epidemiol. 2017 Feb 15;185(4):304-315. PMID: 28073767. 
  • Boland F, Quirke F, Gannon B, Plunkett S, Hayden J, McCourt J, O'Sullivan R, Eustace J, Deasy C, Wakai A. The Penicillin for the Emergency Department Outpatient treatment of CELLulitis (PEDOCELL) trial: update to the study protocol and detailed statistical analysis plan (SAP). Trials. 2017 Aug 24;18(1):391. PMID: 28836993. 
  • Murphy ME, Byrne M, Galvin R, Boland F, Fahey T and Smith S. Improving risk factor management for patients with poorly controlled type 2 diabetes: A systematic review of healthcare interventions in primary care and community settings. BMJ Open. 2017 Aug 4;7(8):e015135. PMID: 28780542. 
  • McCarthy C, Clyne B, Corrigan D, Boland F, Wallace E, Moriarty F, Fahey T, Hughes C, Gillespie P, Smith SM. Supporting prescribing in older people with multimorbidity and significant polypharmacy in primary care (SPPiRE): a cluster randomised controlled trial protocol and pilot. Implement Sci. 2017 Aug 1;12(1):99. PMID: 28764753. 
  • Sulaiman I, Seheult J, Sadasivuni N, MacHale E, Killane I, Giannoutsos S, Cushen B, Mokoka MC, Bhreathnach AS, Boland F, Reilly RB, Costello RW. The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler. J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):247-255. PMID: 28277810. 
  • Quirke M, Ayoub F, McCabe A, Boland F, Smith B, O'Sullivan R, Wakai A. Risk factors for non-purulent leg cellulitis: a systematic review and meta-analysis. Br J Dermatol. 2017 Aug;177(2):382-394. PMID: 27864837.
  • Kelly M, Feeley I, Boland F and O'Byrne JM. (2017). Undergraduate Clinical Teaching in Orthopedic Surgery: A Randomized Control Trial Comparing the Effect of Case-Based Teaching and Bedside Teaching on Musculoskeletal OSCE Performance. J Surg Educ. 2017 Jul 15. pii: S1931-7204(16)30388-9. [Epub ahead of print] PMID: 28720423. 
  • Walsh ME, Galvin R, Boland F, Williams D, Harbison JA, Murphy S, Collins R, Crowe M, McCabe DJH, Horgan F. Validation of two risk-prediction models for recurrent falls in the first year after stroke: a prospective cohort study. Age Ageing. 2017 Jul 1;46(4):642-648. PMID: 28104593. 
  • Clyne B, Cooper JA, Boland F, Hughes CM, Fahey T, Smith SM. Beliefs about prescribed medication among older patients with polypharmacy: A mixed methods study in primary care. Br J Gen Pract. 2017 Jul;67(660):e507-e518. PMID: 28533200. 
  • Mokoka MC, Lombard L, MacHale EM, Walsh J, Cushen B, Sulaiman I, Carthy DM, Boland F, Doyle F, Hunt E, Murphy DM, Faul J, Butler M, Hetherington K, Mark-Fitzgerald J, Van Boven JFM, Heaney LG, Reilly RB, Costello RW. In patients with severe uncontrolled asthma, does knowledge of adherence and inhaler technique using electronic monitoring improve clinical decision making? A protocol for a randomised controlled trial. BMJ Open. 2017 Jun 15:7(6):e015367. PMID: 28619778. 
  • Sulaiman I, Cushen B, Greene G, Seheult J, Seow D, Rawat F, MacHale E, Mokoka M, Moran CN, Bhreathnach AS, MacHale P, Tappuni S, Deering B, Jackson M, McCarthy H, Mellon L, Doyle F, Boland F, Reilly RB, Costello RW. Objective Assessment of Adherence to Inhalers by COPD Patients. Am J Respir Crit Care Med. 2017 May 15;195(10):1333-1343. PMID: 27409253. 
  • Stevens, NT, McDermott H, Boland F, Pawlikowska T, Humphreys H. A comparative study: Do "clickers" increase student engagement in multidisciplinary clinical microbiology teaching? BMC Med Educ. 2017 Apr 8;17(1):70. PMID: 28390400. 
  • Cousins G, Boland F, Barry J, Lyons S, Keenan E, O’Driscoll D, Bennett K, Fahey T. J-shaped relationship between supervised methadone consumption and retention in methadone maintenance treatment (MMT) in primary care: National cohort study. Drug Alcohol Depend. 2017 Apr 1;173:126-131. PMID: 28232249. 
  • Jabakhanji SB, Pavlova M, Groot W, Boland F, Biesma R. Social class variation, the effect of the economic recession and childhood obesity at 3 years of age in Ireland. Eur J Public Health. 2017 Apr 1;27(2):234-239. PMID: 28108592. 
  • Ward M, McAuliffe E, Wakai A, Geary U, Browne J, Deasy C, Schull M, Boland F, McDaid F, Coughlan E, O’Sullivan R. Study protocol for evaluating the implementation and effectiveness of an emergency department longitudinal patient monitoring system using a mixed-methods approach. BMC Health Serv Res. 2017 Jan 23;17(1):67. PMID: 28114987. 
  • Farrelly L, Rosato-Siri MV, Föcking M, Codagnone M, Reines A, Dicker P, Wynne K, Farrell M, Cannon M, Cagney G, Pasquini JM, Cotter DR. The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis. Proteomics. 2017 Sep;17(17-18). PMID: 28762254. 
  • Monteith C, McSweeney L, Breatnach CR, Doherty A, Shirren L, Tully EC, Dicker P, Malone FD, El-Khuffash A, Kent E. Non-invasive cardiac output monitoring (NICOM®) can predict the evolution of uteroplacental disease-Results of the prospective HANDLE study. Eur J Obstet Gynecol Reprod Biol. 2017 Sep;216:116-124. PMID: 28753499. 
  • Harrington CM, Kavanagh DO, Ryan D, Dicker P, Lonergan PE, Traynor O, Tierney S. Objective scoring of an electronic surgical logbook: Analysis of impact and observations within a surgical training body. Am J Surg. 2017 Jul 21. pii: S0002-9610(16)30832-7. [Epub ahead of print] PMID: 28781101. 
  • Levine TA, Grunau RE, Segurado R, Daly S, Geary MP, Kennelly MM, O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD, Alderdice FA, McAuliffe FM. Pregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction. BMJ Open. 2017 Jun 21;7(6):e015326. PMID: 28637734. 
  • Harrington CM, Bresler R, Ryan D, Dicker P, Traynor O, Kavanagh DO. The correlation between fundamental characteristics and first-time performance in laparoscopic tasks. Am J Surg. 2017 Jun 8. pii: S0002-9610(17)30047-8. [Epub ahead of print] PMID: 28624230. 
  • Burke N, Burke G, Breathnach F, McAuliffe F, Morrison JJ, Turner M, Dornan S, Higgins JR, Cotter A, Geary M, McParland P, Daly S, Cody F, Dicker P, Tully E, Malone FD; Perinatal Ireland Research Consortium. Prediction of cesarean delivery in the term nulliparous woman: results from the prospective, multicenter Genesis study. Am J Obstet Gynecol. 2017 Jun;216(6):598.e1-598.e11. PMID: 28213060. 
  • Hehir MP, Breathnach FM, Hogan JL, Mcauliffe FM, Geary MP, Daly S, Higgins J, Hunter A, Morrison JJ, Burke G, Mahony R, Dicker P, Tully E, Malone FD. Prenatal prediction of significant intertwin birthweight discordance using standard second and third trimester sonographic parameters. Acta Obstet Gynecol Scand. 2017 Apr;96(4):472-478. PMID: 28052317. 
  • Monteith C, Flood K, Mullers S, Unterscheider J, Breathnach F, Daly S, Geary MP, Kennelly MM, McAuliffe FM, O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD. Evaluation of normalization of cerebro-placental ratio as a potential predictor for adverse outcome in SGA fetuses. Am J Obstet Gynecol. 2017 Mar;216(3):285.e1-285.e6. PMID: 27840142. 
  • Harrington CM, Kavanagh DO, Quinlan JF, Ryan D, Dicker P, O'Keeffe D, Traynor O, Tierney S. Development and evaluation of a trauma decision-making simulator in Oculus virtual reality. Am J Surg. 2017 Feb 10. pii: S0002-9610(17)30040-5. [Epub ahead of print] PMID: 28262203.

2016

  • Madden SF, Toomey S, Furney SJ, Fan Y, McCormack M, Stapleton C, Cremona M, Cavalleri GL, Milewska M, Elster N, Carr A, Fay J, Kay EW, Kennedy S, Crown J, Gallagher WM, Hennessy BT, Eustace AJ. The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer. Oncotarget. 2016 Nov 15;7(46):75518-75525. PMID: 27776352.
  • Caiazza F, Murray A, Madden SF, Synnott NC, Ryan EJ, O'Donovan N, Crown J, Duffy MJ. Preclinical evaluation of the AR inhibitor enzalutamide in triple-negative breast cancer cells. Endocr Relat Cancer. 2016 Apr;23(4):323-34. PMID: 26932782.
  • Robles-Espinosa CD, Roberts N, Chen S, Leacy FP, Alexandrov LB, Pornputtapong N, Halaban R, Krauthammer M, Cui R, Bishop DT, Adams DJ. Germline MCR1 status influences somatic mutation burden in melanoma. Nat Commun. 2016 Jul 12;7:12064. PMID: 27403562.
  • Sulaiman I, Seheult J, MacHale E, Boland F, O'Dwyer S, Rapcan V, D'Arcy S, Cushen B, Mokoka M, Killane I, Ryder SA, Reilly RB, Costello RW. A Method to Calculate Adherence to Inhaled Therapy That Reflects the Changes in Clinical Features of Asthma. Ann Am Thorac Soc. 2016 Nov;13(11):1894-1903. PMID: 27467125.
  • Sulaiman I, Seheult J, MacHale E, D'Arcy S, Boland F, McCrory K, Casey J, Bury G, Al-Alawi M, O'Dwyer S, Ryder SA, Reilly RB Costello RW. Irregular and Ineffective: A Quantitative Observational Study of the Time and Technique of Inhaler Use. J Allergy Clin Immunol Pract. 2016 Sept-Oct;4(5):900-909.e2. PMID: 27587321.
  • Clyne B, Smith SM, Hughes CM, Boland F, Cooper JA, Fahey T. Sustained effectiveness of a multifaceted intervention to reduce potentially inappropriate prescribing in older patients in primary care (OPTI-SCRIPT study). Implement Sci. 2016 Jun 2;11(1):79. PMID: 27255504.
  • O’Dwyer SM, MacHale E, Sulaiman I, Holmes M, Hughes C, D’Arcy S, Rapcan V, Taylor T, Boland F, Bosnic-Anticevich S, Reilly RB, Ryder SA, Costello RW. The effect of providing feedback on inhaler technique and adherence from an electronic audio recording device, INCA®, in a community pharmacy setting: Study protocol for a randomised controlled trial. Trials. 2016 May 4;17(1):226. PMID: 27142873.
  • Redmond P, Carroll H, Grimes T, Galvin R, McDonnell R, Boland F, McDowell R, Hughes C, Fahey T. GPs’ and community pharmacists’ opinions on medication management at transitions of care in Ireland. Fam Pract. 2016 Apr;33(2):172-8. PMID: 26984995.
  • Föcking M, Dicker P, Lopez LM, Hryniewiecka M, Wynne K, English JA, Cagney G, Cotter DR. Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. Transl Psychiatry. 2016 Nov 29;6(11):e959. PMID: 27898073.
  • Husarova V, Macdarby L, Dicker P, Malone FD, McCaul CL. The use of pain relief during labor among migrant obstetric populations. Int J Gynaecol Obstet. 2016 Nov;135(2):200-204. PMID: 27663486.
  • O'Hare T, McDermott M, O'Sullivan M, Dicker P, Antao B. A Retrospective Cohort Study of Total Colonic Aganglionosis: Is the Appendix a Reliable Diagnostic Tool? J Neonatal Surg. 2016 Oct 10;5(4):44. PMID: 27896152.
  • Hehir MP, Breathnach FM, McAuliffe FM, Geary MP, Daly S, Higgins J, Hunter A, Morrison JJ, Burke G, Higgins S, Mahony R, Dicker P, Tully EC, Malone FD. Gestational hypertensive disease in twin pregnancy: Influence on outcomes in a large national prospective cohort. Aust N Z J Obstet Gynaecol. 2016 Oct;56(5):466-470. PMID: 27302243.
  • Föcking M, Dicker P, Lopez LM, Cannon M, Schäfer MR, McGorry PD, Smesny S, Cotter DR, Amminger GP. Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder? BMC Psychiatry. 2016 Sep 20;16(1):326. PMID: 27650124.
  • O'Halloran PJ, Viel T, Murray DW, Wachsmuth L, Schwegmann K, Wagner S, Kopka K, Jarzabek MA, Dicker P, Hermann S, Faber C, Klasen T, Schäfers M, O'Brien D, Prehn JH, Jacobs AH, Byrne AT. Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers. Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1673-83. PMID: 26975402.
  • Corcoran S, Briggs K, O' Connor H, Mullers S, Monteith C, Donnelly J, Dicker P, Franklin O, Malone FD, Breathnach FM. Prenatal detection of major congenital heart disease - optimising resources to improve outcomes. Eur J Obstet Gynecol Reprod Biol. 2016 Aug;203:260-3. PMID: 27359082.
  • Müllers SM, Burke N, Flood K, Cowman J, O'Connor H, Cotter B, Kearney M, Dempsey M, Dicker P, Tully E, Geary MP, Kenny D, Malone FD. Altered Platelet Function in Intrauterine Growth Restriction: A Cause or a Consequence of Uteroplacental Disease? Am J Perinatol. 2016 Jul;33(8):791-9. PMID: 26906182. 
  • Mone F, Mulcahy C, McParland P, Stanton A, Culliton M, Downey P, McCormack D, Tully E, Dicker P, Breathnach F, Malone FD, McAuliffe FM. An open-label randomized-controlled trial of low dose aspirin with an early screening test for pre-eclampsia and growth restriction (TEST): Trial protocol. Contemp Clin Trials. 2016 Jul;49:143-8. PMID: 27394381.
  • Brugha R, McAleese S, Dicker P, Tyrrell E, Thomas S, Normand C, Humphries N. Passing through - reasons why migrant doctors in Ireland plan to stay, return home or migrate onwards to new destination countries. Hum Resour Health. 2016 Jun 30;14(Suppl 1):35. PMID: 27381409. 
  • Dempsey MA, Flood K, Burke N, Murray A, Cotter B, Muellers S, Dicker P, Fletcher P, Geary M, Malone FD, Kenny D. Viable pregnancies beyond 28 weeks gestation in women with a history of unexplained recurrent miscarriage have reduced platelet function. Eur J Obstet Gynecol Reprod Biol. 2016 May;200:76-81. PMID: 26994466.
  • Burke N, Flood K, Muellers S, Murray A, Dunne E, Cotter B, Dempsey M, Dicker P, Geary MP, Kenny D, Malone FD. Reduced spontaneous platelet aggregation: a novel risk factor for adverse pregnancy outcome. Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:132-6. PMID: 26927895.
  • Halling C, Malone FD, Breathnach FM, Stewart MC, McAuliffe FM, Morrison JJ, Dicker P, Manning F, Corcoran JD; Perinatal Ireland Research Consortium. Neuro-developmental outcome of a large cohort of growth discordant twins. Eur J Pediatr. 2016 Mar;175(3):381-9. PMID: 26490567.