Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Publications

  • Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H, De Bundel D, Vermoesen K, Bannai S, Smolders I, Conrad M, Plesnila N, Sato H, Michotte Y. Dopaminergic neurons of system xFormula-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB J. 2011 Apr;25(4):1359-69. Epub 2010 Dec 29. PMID: 21191088
  • Engel T, Plesnila N, Prehn JH, Henshall DC. In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab. 2011 Mar 2. PMID: 1364604
  • Plesnila N. Fluid resuscitation after traumatic brain injury with hypovolemic shock: still a bloody business? Crit Care Med. 2011 Mar;39(3):592-3. PMID: 21330861 Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C. Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 2011 Feb;18(2):282-92. Epub 2010 Aug 6. PMID: 20689558
  • Tsuchiya T, Bonner HP, Engel T, Woods I, Matsushima S, Ward MW, Taki W, Henshall DC, Concannon CG, Prehn JH. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. Eur J Neurosci. 2011 Feb;33(3):401-8. doi: 10.1111/j.1460-9568.2010.07538.x. Epub 2010 Dec 31. PMID: 21198986
  • Weisová P, Dávila D, Tuffy LP, Ward MW, Concannon CG, Prehn JH. Role of 5'-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons. Antioxid Redox Signal. 2011 Feb 18. [Epub ahead of print] PMID: 20712420
  • Schöller K, Feiler S, Anetsberger S, Kim SW, Plesnila N. Contribution of Bradykinin Receptors to the Development of Secondary Brain Damage After Experimental Subarachnoid Hemorrhage. Neurosurgery. 2011 Jan 13. [Epub ahead of print]PMID: 21242838
  • Behan ÁT, van den Hove DL, Mueller L, Jetten MJ, Steinbusch HW, Cotter DR, Prickaerts, J. Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. Eur Neuropsychopharmacology 2011 Jan; 21(1):71-9. PMID: 20702067
  • Foley NH, Bray I, Watters KM, Das S, Bryan K, Bernas T, Prehn JH, Stallings RL. MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2. Cell Death Differ. 2011 Jan 7. PMID: 21212796
  • Tuffy LP, Concannon CG, D'Orsi B, King MA, Woods I, Huber HJ, Ward MW, Prehn JH. Mol Cell Biol. 2010 Dec;30(23):5484-501. Epub 2010 Oct 4. Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition. PMID: 20921277
  • O'Tuathaigh CM, Hryniewiecka M, Behan ÁT, Tighe O, Coughlan C, Desbonnet L, Cannon M, Karayiorgou M, Gogos JA, Cotter DR, Waddington JL. Chronic Adolescent Exposure to ?-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes. Neuropsychopharmacology. 2010 35(11):2262-73. PMID: 20631688
  • McMorrow C, Fredsted A, Carberry J, O'Connell RA, Bradford A, Jones JFX, O'Halloran KD. Chronic hypoxia increases rat diaphragm muscle endurance and Na+-K+ pump content. Eur Respir J. 2010; Dec 9[Epub ahead of print]PMID: 21148231
  • Engel T, Caballero-Caballero A, Schindler CK, Plesnila N, Strasser A, Prehn JH, Henshall DC. BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor. J Neurochem. 2010 Oct;115(1):92-101. doi: 10.1111/j.1471-4159.2010.06909.x. Epub 2010 Jul 30. PMID: 20646170
  • Engel T, Tanaka K, Jimenez-Mateos EM, Caballero-Caballero A, Prehn JH, Henshall DC. Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis. 2010 Oct 7;1(10):e79. PMID: 21368852
  • Thal SC, Thal SE, Plesnila N. Characterization of a 3-vessel occlusion model for the induction of complete global cerebral ischemia in mice. J Neurosci Methods. 2010 Oct 15;192(2):219-27. Epub 2010 Aug 3. PMID: 20688105
  • Zhdanov AV, Ward MW, Taylor CT, Souslova EA, Chudakov DM, Prehn JH, Papkovsky DB. . Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.
  • Biochim Biophys Acta. PMID: Biochim Biophys Acta. (Sep 2010)
  • Bunk EC, König HG, Bonner HP, Kirby BP, Prehn JH. NMDA-induced injury of mouse organotypic hippocampal slice cultures triggers delayed neuroblast proliferation in the dentate gyrus: an in vitro model for the study of neural precursor cell proliferation. Brain Res. 2010 Nov 4;1359:22-32. Epub 2010 May 15. PMID: 20478273
  • Feiler S, Friedrich B, Schöller K, Thal SC, Plesnila N. Standardized induction of subarachnoid hemorrhage in mice by intracranial pressure monitoring. J Neurosci Methods. 2010 Jul 15;190(2):164-70. Epub 2010 May 10. PMID: 20457182
  • Bonner HP, Concannon CG, Bonner C, Woods I, Ward MW, Prehn JH. Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability. J Neurochem. 2010 Jul;114(2):606-16. Epub 2010 Apr 30. PMID: 20477911
  • Grohm J, Plesnila N, Culmsee C. Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 2010 Jul;24(5):831-8. Epub 2009 Dec 2. PMID: 19961923
  • Carberry J, Bradford A, O'Halloran KD. Antioxidant treatment does not prevent chronic hypoxia-induced respiratory muscle impairment in developing rats. Adv Exp Med Biol. 2010;669:263-6.PMID: 20217362
  • Skelly JR, Bradford A, O'Halloran KD. Intermittent hypoxia impairs pharyngeal dilator muscle function in male but not female rats. Adv Exp Med Biol. 2010;669:285-7.PMID: 20217367 Skelly JR, Bradford A, Jones JF, O'Halloran KD. Superoxide Scavengers Improve Rat Pharyngeal Dilator Muscle Performance. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):725-731 [Epub 2009 Jul 27] PMID: 19635929
  • Ward MW, Concannon CG, Whyte J, Walsh CM, Corley B, Prehn JH. The amyloid precursor protein intracellular domain (AICD) disrupts actin dynamics and mitochondrial bioenergetics. J Neurochem. 2010 Apr;113(1):275-84. PMID: 20405578
  • Engel T, Hatazaki S, Tanaka K, Prehn JH, Henshall DC. Deletion of Puma protects hippocampal neurons in a model of severe status epilepticus. Neuroscience. 2010 Jun 30;168(2):443-50. Epub 2010 Apr 1. PMID: 20362645
  • Concannon CG, Tuffy LP, Weisová P, Bonner HP, Dávila D, Bonner C, Devocelle MC, Strasser A, Ward MW, Prehn JH. AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis. J Cell Biol. 2010 Apr 5;189(1):83-94. Epub 2010 Mar 29.PMID: 20351066
  • Klinkenberg M, Thurow N, Gispert S, Ricciardi F, Eich F, Prehn JH, Auburger G, Kögel D. Enhanced vulnerability of PARK6 patient skin fibroblasts to apoptosis induced by proteasomal stress. Neuroscience. 2010 Mar 17;166(2):422-34. Epub 2010 Jan 4. PMID: 20045449
  • Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC. Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB J. 2010 Mar;24(3):853-61. Epub 2009 Nov 4. PMID: 19890018
  • Murphy BM, Engel T, Paucard A, Hatazaki S, Mouri G, Tanaka K, Tuffy LP, Jimenez-Mateos EM, Woods I, Dunleavy M, Bonner HP, Meller R, Simon RP, Strasser A, Prehn JH, Henshall DC. Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. Cell Death Differ. 2010 Mar;17(3):459-68. Epub 2009 Sep 25. PMID: 19779495
  • Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Strieth S, Deppe C, Mees K. Level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig depend on the stimulus frequency. Eur Arch Otorhinolaryngol. 2010 Mar;267(3):351-5. Epub 2009 Jul 21. PMID: 19629511
  • Cardoso AL, Costa P, de Almeida LP, Simões S, Plesnila N, Culmsee C, Wagner E, de Lima MC. Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo. J Control Release. 2010 Mar 19;142(3):392-403. Epub 2009 Nov 11. PMID: 19913061
  • van den Maagdenberg AM, Pizzorusso T, Kaja S, Terpolilli N, Shapovalova M, Hoebeek FE, Barrett CF, Gherardini L, van de Ven RC, Todorov B, Broos LA, Tottene A, Gao Z, Fodor M, De Zeeuw CI, Frants RR, Plesnila N, Plomp JJ, Pietrobon D, Ferrari MD. High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice. Ann Neurol. 2010 Jan;67(1):85-98. PMID: 20186955
  • Schwarzmaier SM, Kim SW, Trabold R, Plesnila N. Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice. J Neurotrauma. 2010 Jan;27(1):121-30. PMID: 19803784
  • Bunk EC, König HG, Bernas T, Engel T, Henshall DC, Kirby BP, Prehn JH. BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis. 2010 Jan;1(1):e15. PMID: 21364616
  • Trabold R, Erös C, Zweckberger K, Relton J, Beck H, Nussberger J, Müller-Esterl W, Bader M, Whalley E, Plesnila N. The role of bradykinin B(1) and B(2) receptors for secondary brain damage after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2010 Jan;30(1):130-9. Epub 2009 Sep 23. PMID: 19773800
  • Terpolilli NA, Zweckberger K, Trabold R, Schilling L, Schinzel R, Tegtmeier F, Plesnila N. The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice. J Neurotrauma. 2009 Nov;26(11):1963-75. PMID: 19514849
  • Thal SC, Sporer S, Klopotowski M, Thal SE, Woitzik J, Schmid-Elsaesser R, Plesnila N, Zausinger S. Brain edema formation and neurological impairment after subarachnoid hemorrhage in rats. Laboratory investigation. J Neurosurg. 2009 Nov;111(5):988-94. PMID: 19425896
  • Sebastià J, Kieran D, Breen B, King MA, Netteland DF, Joyce D, Fitzpatrick SF, Taylor CT, Prehn JH. Angiogenin protects motoneurons against hypoxic injury. Cell Death Differ. 2009 Sep;16(9):1238-47. Epub 2009 May 15. PMID: 19444281
  • Török E, Klopotowski M, Trabold R, Thal SC, Plesnila N, Schöller K. Mild hypothermia (33 degrees C) reduces intracranial hypertension and improves functional outcome after subarachnoid hemorrhage in rats. Neurosurgery. 2009 Aug;65(2):352-9; discussion 359. PMID: 19625915
  • Thal SC, Sporer S, Schmid-Elsaesser R, Plesnila N, Zausinger S. Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome. Crit Care Med. 2009 Jul;37(7):2228-34. PMID: 19487935.
  • Behan ÁT, Byrne C, Dunn M, Cagney G, Cotter DR. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. Molecular Psychiatry 2009 14(6):601-13. PMID: 18268500
  • Zweckberger K, Plesnila N. Anatibant, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury. Neurosci Lett. 2009 Apr 24;454(2):115-7. Epub 2009 Feb 11. PMID: 19429066
  • Weisová P, Concannon CG, Devocelle M, Prehn JH, Ward MW. Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons. J Neurosci. 2009 Mar 4;29(9):2997-3008. PMID: 19261894
  • Kuroki K, Virard I, Concannon CG, Engel T, Woods I, Taki W, Plesnila N, Henshall DC, Prehn JH. Effects of transient focal cerebral ischemia in mice deficient in puma. Neurosci Lett. 2009 Feb 27;451(3):237-40. Epub 2009 Jan 13. PMID: 19159665
  • Cox D, Bradford A. Continuous positive airway pressure and platelet activation in obstructive sleep apnoea. Respiration. 2009;77(1):18-20. Epub 2008 Oct 13. PMID: 18849598
  • Edge D, Skelly JR, Bradford A, O'Halloran KD. Ventilatory drive is enhanced in male and female rats following chronic intermittent hypoxia.Adv Exp Med Biol 2009; 648: 337-344. PMID: 19536497
  • King MA, Goemans CG, Hafiz F, Prehn JH, Wyttenbach A, Tolkovsky AM. Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. J Neurosci. 2008 Dec 31;28(53):14401-15. PMID: 19118173
  • Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JH. Control of motoneuron survival by angiogenin. J Neurosci. 2008 Dec 24;28(52):14056-61. PMID: 19109488
  • Jimenez-Mateos EM, Hatazaki S, Johnson MB, Bellver-Estelles C, Mouri G, Bonner C, Prehn JH, Meller R, Simon RP, Henshall DC. Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways. Neurobiol Dis. 2008 Dec;32(3):442-53. Epub 2008 Sep 4. PMID: 18804535
  • Trabold R, Krieg S, Schöller K, Plesnila N. Role of vasopressin V(1a) and V2 receptors for the development of secondary brain damage after traumatic brain injury in mice. J Neurotrauma. 2008 Dec;25(12):1459-65. PMID: 19118456
  • Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N. Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol. 2008 Dec;173(6):1795-805. Epub 2008 Nov 6. PMID:18988795
  • Olzowy B, von Gleichenstein G, Canis M, Plesnila N, Mees K. Complex level alterations of the 2f (1)-f (2) distortion product due to hypoxia in the guinea pig. Eur Arch Otorhinolaryngol. 2008 Nov;265(11):1329-33. Epub 2008 Apr 4. PMID:1838926
  • Cardoso AL, Simões S, de Almeida LP, Plesnila N, Pedroso de Lima MC, Wagner E, Culmsee C. Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS.J Control Release. 2008 Dec 8;132(2):113-23. Epub 2008 Sep 2. PMID: 18796321
  • Landshamer S, Hoehn M, Barth N, Duvezin-Caubet S, Schwake G, Tobaben S, Kazhdan I, Becattini B, Zahler S, Vollmar A, Pellecchia M, Reichert A, Plesnila N, Wagner E, Culmsee C. Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death Differ. 2008 Oct;15(10):1553-63. Epub 2008 Jun 6. PMID: 18535584
  • Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48. PMID:18762024
  • Ringel F, Plesnila N. Expression and functional role of potassium-chloride cotransporters (KCC) in astrocytes and C6 glioma cells. Neurosci Lett. 2008 Sep 19;442(3):219-23. Epub 2008 Jul 11. PMID: 1863852
  • Hetschko H, Voss V, Senft C, Seifert V, Prehn JH, Kögel D. BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. Neoplasia. 2008 Aug;10(8):873-85. PMID:18670645
  • Murphy N, Bonner HP, Ward MW, Murphy BM, Prehn JH, Henshall DC. Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures. J Neurochem. 2008 Jul;106(2):978-88. Epub 2008 May 2. PMID: 18466333
  • Engel DC, Mies G, Terpolilli NA, Trabold R, Loch A, De Zeeuw CI, Weber JT, Maas AI, Plesnila N. Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol. J Neurotrauma. 2008 Jul;25(7):739-53. PMID: 18627253
  • von Baumgarten L, Trabold R, Thal S, Back T, Plesnila N. Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2008 Jul;28(7):1353-60. Epub 2008 Apr 16. PMID: 18414497
  • Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK. Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol. 2008 Jul;173(1):77-92. Epub 2008 Jun 13. PMID: 18556777
  • Cathcart MC, Tamosiuniene R, Chen G, Neilan TG, Bradford A, O'Byrne KJ, Fitzgerald DJ, Pidgeon GP. Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis. J Pharmacol Exp Ther. 2008 Jul;326(1):51-8. Epub 2008 PMID: 18375790
  • Concannon CG, Ward MW, Bonner HP, Kuroki K, Tuffy LP, Bonner CT, Woods I, Engel T, Henshall DC, Prehn JH. NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner. J Neurochem. 2008 May;105(3):891-903. Epub 2007 Dec 13. PMID: 18088354
  • Hetschko H, Voss V, Seifert V, Prehn JH, Kögel D. Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis. FEBS J. 2008 Apr;275(8):1925-36. Epub 2008 Mar 13. PMID: 18341587
  • Zhdanov AV, Ward MW, Prehn JH, Papkovsky DB. Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission. J Biol Chem. 2008 Feb 29;283(9):5650-61. Epub 2007 Dec 17. PMID: 18086678
  • Kieran D, Woods I, Villunger A, Strasser A, Prehn JH. Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20606-11. Epub 2007 Dec 11. PMID: 18077368
  • Gomez-Lazaro M, Galindo MF, Concannon CG, Segura MF, Fernandez-Gomez FJ, Llecha N, Comella JX, Prehn JH, Jordan J. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem. 2008 Mar;104(6):1599-612. Epub 2007 Nov 6. PMID: 17996028
  • Dunleavy M, Bradford A, O'Halloran KD. Oxidative stress impairs upper airway muscle endurance in an animal model of sleep-disordered breathing.Adv Exp Med Biol 2008; 605: 458-462. PMID: 18085317
  • Hetschko H, Voss V, Horn S, Seifert V, Prehn JH, Kögel D. Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma. J Neurooncol. 2008 Feb;86(3):265-72. Epub 2007 Oct 9. PMID: 17924059
  • Hatazaki S, Bellver-Estelles C, Jimenez-Mateos EM, Meller R, Bonner C, Murphy N, Matsushima S, Taki W, Prehn JH, Simon RP, Henshall DC. Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning. Neuroscience. 2007 Dec 5;150(2):467-77. Epub 2007 Sep 14. PMID: 17935890
  • Behan ÁT, Foy M, Wynne K, Clarke M, Cotter DR, Maguire PB. (2007) Analysis of membrane microdomain-associated proteins in the insular cortex of post-mortem human brain.. Proteomics Clin. Appl. 2007,Oct 1,(10) 1324-1331.PMID 21136629
  • Cronin S, Greenway MJ, Prehn JH, Hardiman O. Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):984-6. PMID: 17702780
  • Ward MW, Huber HJ, Weisová P, Düssmann H, Nicholls DG, Prehn JH. Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. J Neurosci. 2007 Aug 1;27(31):8238-49. PMID: 17670970
  • König HG, Rehm M, Gudorf D, Krajewski S, Gross A, Ward MW, Prehn JH. Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons. BMC Cell Biol. 2007 Feb 27;8:7. PMID: 17326836
  • Gomez-Lazaro M, Galindo MF, Melero-Fernandez de Mera RM, Fernandez-Gómez FJ, Concannon CG, Segura MF, Comella JX, Prehn JH, Jordan J. Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol Pharmacol. 2007 Mar;71(3):736-43. Epub 2006 Dec 15. PMID: 17172466
  • Raza A, Farrell Tl, O'Halloran KD, Bradford A. The effects of breath-holds and Muller manoeuvres on upper airway carbon dioxide concentration in humans. Respiration 2007 Jan 24; 74: 533-6. PMID: 17259692
  • Bradford A. The role of hypoxia and platelets in air travel-related venous thromboembolism. Current Pharmaceutical Design. 2007; 13: 2668-72. Review. PMID: 17897010 Cronin S, Greenway MJ, Ennis S, Kieran D, Green A, Prehn JH, Hardiman O. Elevated serum angiogenin levels in ALS. Neurology. 2006 Nov 28;67(10):1833-6. PMID: 17130418 Copanaki E, Schürmann T, Eckert A, Leuner K, Müller WE, Prehn JH, Kögel D. The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta. 2007 Feb;1773(2):157-65. Epub 2006 Oct 19. PMID: 17113167
  • Müller T, Concannon CG, Ward MW, Walsh CM, Tirniceriu AL, Tribl F, Kögel D, Prehn JH, Egensperger R. Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). Mol Biol Cell. 2007 Jan;18(1):201-10. Epub 2006 Nov 8. PMID: 17093061
  • Kögel D, Svensson B, Copanaki E, Anguissola S, Bonner C, Thurow N, Gudorf D, Hetschko H, Müller T, Peters M, König HG, Prehn JH. Induction of transcription factor CEBP homology protein mediates hypoglycaemia-induced necrotic cell death in human neuroblastoma cells. J Neurochem. 2006 Nov;99(3):952-64. Epub 2006 Aug 29. PMID: 1694259
  • Schultz C, König HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kögel D, Deller T. Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci. 2006 Sep;33(1):68-80. Epub 2006 Jul 27. PMID: 16875840
  • Gerlach R, Demel G, König HG, Gross U, Prehn JH, Raabe A, Seifert V, Kögel D. Active secretion of S100B from astrocytes during metabolic stress. Neuroscience. 2006 Sep 15;141(4):1697-701. Epub 2006 Jun 19. PMID: 16782283
  • Beasley CL, Pennington K, Behan ÁT, Wait R, Dunn MJ, Cotter DR. Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes. Proteomics. 2006 Jun;6(11):3414-25.. PMID:16637010
  • Behan ÁT, Cotter DR. Neuropathology of mood disorders. Psychiatry May 2006;5(5): 180-182.
  • Schindler CK, Pearson EG, Bonner HP, So NK, Simon RP, Prehn JH, Henshall DC. Caspase-3 cleavage and nuclear localization of caspase-activated DNase in human temporal lobe epilepsy. J Cereb Blood Flow Metab. 2006 Apr;26(4):583-9. PMID: 16121124
  • Yamamoto A, Murphy N, Schindler CK, So NK, Stohr S, Taki W, Prehn JH, Henshall DC. Endoplasmic reticulum stress and apoptosis signaling in human temporal lobe epilepsy. J Neuropathol Exp Neurol. 2006 Mar;65(3):217-25. PMID: 16651883
  • Ward MW, Rehm M, Duessmann H, Kacmar S, Concannon CG, Prehn JH. Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis. J Biol Chem. 2006 Mar 3;281(9):5837-44. Epub 2005 Dec 28. PMID: 16407197
  • Gomez-Lazaro M, Galindo MF, Fernandez-Gomez FJ, Prehn JH, Jordán J. Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cells. Exp Neurol. 2005 Nov;196(1):96-103. Epub 2005 Aug 19. PMID: 16112113
  • Bradford A, McGuire M, O'Halloran KD. Episodic hypoxia impairs pharyngeal dilator muscle function: implications for pathophysiology of obstructive sleep apnoea. Respir Physiol Neurobiol. 2005 Jul 28; 147 (2-3): 223-234. PMID:
  • Behan ÁT, Doyle S, Farrell M. Adaptive responses to mitochondrial dysfunction in the rho(O) Namalwa cell. Mitochondrion. 2005 Jun;5(3):173-93. PMID:16050983 König HG, Kögel D, Rami A, Prehn JH. TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol. 2005 Mar 28;168(7):1077-86. Epub 2005 Mar 21. PMID: 15781474
  • Dunleavy M, Dooley M, Cox D, Bradford A. Chronic intermittent asphyxia increases platelet reactivity in rats. Exp Physiol. 2005 Feb 22; 90(3): 411-6. PMID: 15728138
  • Martial FP, Dunleavy M, Nolan P, McNicholas W, O'Regan RG, Bradford A. Simultaneous recording of breathing and respiratory related neuronal activity in the brainstem of conscious rats. Respir Physiol Neurobiol. 2005 Feb 15 ; 145(2-3) : 301-6. PMID : 15705544
  • Kögel D, Schomburg R, Copanaki E, Prehn JH. Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death Differ. 2005 Jan;12(1):1-9. PMID: 15592359
  • Pidgeon GP, Tamosiuniene R, Chen G, Leonard I, Belton O, Bradford A, Fitzgerald D. Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by different cyclooxygenase-2. Circulation. 2004 Oct 26; 110(17): 2701-7. PMID: 15492320
  • Ward MW, Kögel D, Prehn JH. Neuronal apoptosis: BH3-only proteins the real killers? J Bioenerg Biomembr. 2004 Aug;36(4):295-8. Review.PMID: 15377860
  • Bradford A. Effects of chronic intermittent asphyxia on haematocrit, pulmonary arterial pressure and skeletal muscle in rats. Exp Physiol, 2004 Jan; 89(1): 44-52. Review PMID: 15109208
  • Kögel D, Peters M, König HG, Hashemi SM, Bui NT, Arolt V, Rothermundt M, Prehn JH. S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury. Neuroscience. 2004;127(4):913-20. PMID: 15312903
  • Jordán J, Ceña V, Prehn JH. Mitochondrial control of neuron death and its role in neurodegenerative disorders. J Physiol Biochem. 2003 Jun;59(2):129-41. Review. PMID: 14649878 Kögel D, Schomburg R, Schürmann T, Reimertz C, König HG, Poppe M, Eckert A, Müller WE, Prehn JH. The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis. J Neurochem. 2003 Oct;87(1):248-56. PMID: 12969271
  • Martial FP, Dunleavy M, Jones JFX, Nolan P, O'Regan RG, McNicholas W, Bradford A. Activity of dorsal medullary respiratory neurons in awake rats Adv Exp Med Biol. 2003; 536: 445-53. PMID: 14635698
  • O'Halloran KD, McGuire M, O'Hare T, MacDermott, Bradford A. Upper airway EMG responses to acute hypoxia and asphyxia are impaired in streptozotocin-induced diabetic rats. Respir Physiol Neurobiol (formerly Respir Physiol). 2003; 138(2-3): 301-8. PMID : 14609518
  • El-Khoury R, O'Halloran K, Bradford A. Effects of chronic hypobaric hypoxia on contractile properties of rat sternohyoid and diaphragm muscles. Clin Exp Pharmacol Physiol, 2003 Aug; 30(8): 551-4.PMID: 12890176
  • Reimertz C, Kögel D, Rami A, Chittenden T, Prehn JH. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J Cell Biol. 2003 Aug 18;162(4):587-97. Epub 2003 Aug 11. PMID: 12913114
  • Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K. Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2003 Jul 17;46(15):3382-94. PMID: 12852768
  • Rothermundt M, Peters M, Prehn JH, Arolt V. S100B in brain damage and neurodegeneration. Microsc Res Tech. 2003 Apr 15;60(6):614-32. Review. PMID:12645009
  • Hughes K, Pickering M, O'Leary D, Bradford A, O'Regan R, Jones JFX. The paraganglia of the rat superior laryngeal nerve. Adv Exp Med Biol 2003; 536: 239-46. PMID: 14635673
  • McGuire M, MacDermott M, Bradford A.Effects of chronic intermittent asphyxia on rat diaphragm and limb muscle contractility Chest, 2003 Mar; 123 (3): 875-81.PMID: 12628891
  • Gagnon M, McGuire M, MacDermott M, Bradford A.Effects of creatine loading and depletion on rat skeletal muscle contraction. Clin Exp Pharmacol Physiol 2002 Oct; 29(10): 885-90.PMID: 12207567
  • McGuire M, MacDermott M, Bradford A. Effects of chronic episodic hypoxia on rat upper airway muscle contractile properties and fiber type distribution. Chest 2002 Sep; 122(3): 1012-7. PMID: 12226048
  • McGuire M, Bradford A, MacDermott M Contractile properties of the diaphragm in creatine fed rats. Clin Exp Pharmacol Physiol. 2002 Sep; 29(9): 782-3 PMID: 12165042
  • Culmsee C, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JH, Mattson MP, Krieglstein J. Nerve growth factor survival signaling in cultured hippocampal neurons is mediated through TrkA and requires the common neurotrophin receptor P75. Neuroscience. 2002;115(4):1089-108. PMID: 12453482
  • Poppe M, Reimertz C, Münstermann G, Kögel D, Prehn JH. Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression. J Neurochem. 2002 Aug;82(3):482-94. PMID: 12153473
  • O'Halloran KD, McGuire M, O'Hare T, Bradford A Chronic intermittent asphyxiaimpairs rat upper airway muscle responses to acute hypoxia and asphyxia. Chest 2002 Jul; 122(1): 269-275.PMID: 12114369 [PubMed - indexed for MEDLINE]
  • Bui NT, König HG, Culmsee C, Bauerbach E, Poppe M, Krieglstein J, Prehn JH. p75 neurotrophin receptor is required for constitutive and NGF-induced survival signalling in PC12 cells and rat hippocampal neurones. J Neurochem. 2002 May;81(3):594-605. PMID: 12065668
  • McGuire M, Cantillon D, Bradford A. Effects of almitrine on diaphragm contractile properties in young and old rats. Resp. 2002 Jan;69:75-80. PMID: 11844967
  • Wang ZH, Bradford A, O'Regan RG. Effects of carbonic anhydrase inhibition on the responsiveness of laryngeal receptors in cats to CO2. Exp Physiol. 2001 Sep;86(Pt 5):641-9. PMID: 11571493
  • McGuire M, Bradford A.Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats. Eur Respir J. 2001 Aug;18(2):279-85. PMID: 11529285
  • McGuire M, Bradford A, MacDermott M. The effects of dietary creatine supplements on the contractile properties of rat soleus and extensor digitorum longus muscles. Exp Physiol. 2001 Mar;86(2):185-90. PMID: 11429633
  • McGuire M, Dumbleton M, MacDermott M, Bradford A. Contractile and electrical properties of sternohyoid muscle in streptozotocin diabetic rats.Clin Exp Pharmacol Physiol. 2001 Mar;28(3):184-7. PMID: 11207673 [PubMed - indexed for MEDLINE]
  • Cantillon D, Bradford A.Effect of almitrine on upper airway muscle contraction in young and old rats.ur J Pharmacol. 2001 Jan 26;412(2):187-94.PMID: 11165230 [PubMed - in process]