Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

FUNDED PhD: Dr James O'Donnell - Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study

This research is part of the Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study, based in the RCSI and St James’s Hospital, Dublin.

Project description

The Irish Personalised Approach to the Treatment of Haemophilia (iPATH) programme is a large translational research study that seeks to make fundamental discoveries in relation to haemophilia biology, thereby enabling novel approaches to patient stratification and ultimately personalised management of haemophilia and haemophiliac arthropathy. The current research strategy is to investigate the molecular mechanisms underpinning the survival of coagulation proteins, including von Willebrand Factor and Factor VIII within the circulation and to investigate how these mechanisms contribute to the inter individual variation in responses to Factor VIII treatment.

Potential applicants should be enthusiastic, driven and willing to work as part of an ambitious multidisciplinary research team. For further information on the group’s research interests and output, see recent relevant publications (Chion et al. Blood 2016, O’Sullivan et al. Journal of Thrombosis and Haemostasis 2016, O’Regan et al. Blood 2016).

  • Research area: Vascular biology
  • Department: MCT-Irish Centre for Vascular Biology
  • Tenure: Four years
  • Salary: €18,000 per year (plus fees) up to a maximum of four years


The successful candidate should be able to demonstrate the following: 


  • An Honours Bachelor degree (grade 2.1 or above) in biomedical science/biochemistry or biology-related discipline
  • Highly motivated with good problem-solving skills
  • Good communication skills
  • Strong organisational and administrative skills with ability to meet deadlines
  • Ability to work on one’s own initiative as well as in a multidisciplinary, team environment
  • Willingness to undertake training and career development
  • Attention to detail and thoroughness in work practices is essential
  • English language requirements for candidates who do not speak English as their first language: an IELTS score of 6.5 or above


  • A Higher Degree or Masters in a related field would be an advantage
  • Prior experience in a research laboratory with skills including tissue culture and basic molecular and cellular techniques would be advantageous.


Application process

Please apply here with the following:

  • An up-to-date CV
  • A completed application form (available from the application portal
  • A 500-word cover letter outlining your interest in and suitability for the position
  • Scanned transcripts (preferred), or detailed degree grade breakdown
  • Contact details of two referees
  • Application deadline: Friday, 27 October 2017 at 5pm.

Mentors Dr James O'Donnell