Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

PhD: Dr Claire McCoy - Understanding the impact of microRNAs in Immunometabolism

This PhD project will specifically focus on understanding how microRNAs regulate the metabolism of innate immune cells such as macrophages, an area of emerging importance in the field of immunology.

Project description

The discovery of microRNAs has led to a very exciting and rapidly growing area of research. microRNAs are extremely small RNA molecules that regulate all aspects of cellular function in the human body. Importantly, microRNAs are critical for immune cell function and are required for a healthy immune response to infection. However, for reasons that we don’t fully understand, microRNAs are also dysregulated in multiple inflammatory diseases, suggesting that they contribute to and/or trigger disease pathogenesis.

The research focus in Dr Claire McCoy’s laboratory is to understand the molecular mechanisms, functions and impact of microRNAs in immune cells, with the aim to translate these findings into inflammatory diseases such as Multiple Sclerosis. This PhD project will specifically focus on understanding how microRNAs regulate the metabolism of innate immune cells such as macrophages, an area of emerging importance in the field of immunology.

This fully funded four-year PhD project will be undertaken in the newly renovated, state-of-the-art laboratories in the Molecular and Cellular Therapeutics department in the main RCSI building beside St Stephen’s Green.

Aside from the core research project, this four-year studentship will offer excellent training opportunities in biostatistics and health services research. The successful candidate will be supported in attending national and international conferences and developing collaborative skills in a multidisciplinary environment.

  • Research theme: Immunometabolism
  • Department: Molecular and Cellular Therapeutics
  • Tenure: Four years
  • Salary: €18,500 per year 

Specification

The successful candidate should be able to demonstrate the following: 

Essential

  • An Honours Bachelor degree (grade 2.1 or above) in biochemistry, immunology, genetics or related-molecular biology discipline
  • Prior experience in a research laboratory with skills in basic molecular techniques
  • Good communication skills
  • Strong organisational and administrative skills
  • Ability to work on one’s own initiative as well as in a multidisciplinary, team environment
  • Willingness to undertake training and career development
  • English language requirements for candidates who do not speak English as their first language: an IELTS score of 6.5 or above

Desirable

  • Candidates with experience in metabolism-related research are highly encouraged to apply

 

Application process

Please apply with an up-to-date CV, a 500-word statement outlining your interest in and suitability for the position and contact details of two referees to clairemccoy@rcsi.ie

  • Application deadline: Friday, 18 August 2017 at 5pm.
  • Interview date: early September 2017
  • Start date: 1 October 2017

Mentors Dr Claire McCoy