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RCSI Advancing Patient Care
39
Impact & Breakthrough - Selected Publications 20122013
RCSI investigators published 177 peer reviewed papers during the
period covered by this annual report. Below is a selection of work
published in high impact journals. We regret that due to space
limitations we could not highlight all of the published works of RCSI
staff.
Professor Mary Cannon (Psychiatry) and colleagues at RCSI
demonstrate that exposure to childhood trauma (physical assault
and bullying) is linked to psychotic experiences, (such as hearing
voices), and in turn, the cessation of traumatic experiences, leads
to a significant reduction in the incidence of psychotic experiences.
These findings were published in the July edition of the American
Journal of Psychiatry. Professor Cannon and her colleagues
also published a paper in the Archives of General Psychiatry,
demonstrating that psychotic symptoms are strongly associated with
increased risk for suicidal behavior in adolescents.
Dr. Susan Smith and colleagues in the HRB Centre for Primary Care
Research in the Department of General Practice published a paper
in the prestigious British Medical Journal on the management of
patients with multimorbidity.
PhD student Catherine Coughlan (Medicine) examined the effects
of aspergillus fumigates infection on vitamin D receptor expression
in cystic fibrosis, providing a rationale for the therapeutic effect
of itraconazole. Her work was published in the American Journal
of Respiratory and Critical Care Medicine, with Professor Gerry
McElvaney as senior author.
Raquel Fernandez, Isabella Bray and Professor Ray Stallings
(MCT) participated in an international collaboration involving
colleagues in the Academic Medical Centre, Amsterdam, and the
Children's Hospital, Essen, which led to the identification of a novel
neuroblastoma oncogene. This work was published in the October
issue of Nature Genetics.
Professors Kieran Murphy (Psychiatry) and John Waddington (MCT)
participated in an international collaboration on the genetics of
schizophrenia, involving colleagues across the globe. The findings
of this study, published in Biological Psychiatry, provided further
support for involvement of MHC class I molecules in schizophrenia.
A team led by Professor Jochen Prehn (Physiology) have developed
a new method of predicting which patients with colorectal cancer will
respond effectively to chemotherapy. The results of this study were
published in the prestigious Cancer Research journal.
Research carried out by Dr Eoghan McCarthy under the supervision
of Professor Caroline Jefferies (MCT) identified disease types in
Irish systemic lupus erythematosus sufferers that are associated with
high levels of BLyS. The research, carried out in collaboration with
the Rheumatology departments of both Beaumont and St James's
hospitals, was published in Rheumatology. The authors concluded
that patients with high levels of BLyS at baseline were more likely
to have active disease and suffer increased organ damage from
their lupus as the disease progressed, suggesting that the use of
Belimumab in these patients may improve their long-term outcomes.

Dr Tidi Hassan (Medicine) and colleagues published a paper in
Nucleic Acids Research. The work describes a novel microRNA
affinity capture technology, which is also the subject of the group's
recent European PCT patent filing (PCT/EP2012/070037).
Dr Catherine Green is the senior author.
The implementation of our
research plan will enhance
RCSI competitiveness through
multi-disciplinary research,
will offer greater professional
development opportunities for
research staff, and will enhance
internal communication.
Pictured at the 3U Neuroscience Meeting
are (l-r) Professors John Waddington and
David Cotter,Ms Ruth Davis, 3U Director; and
Professors David Henshall and Jochen Prehn.
Professor David Whitford and Dr Frances
Meagher at Research Day 2013.
Professor Brian Harvey speaks to the crowd at
Michigan State University (MSU) where he was
awarded an honorary degree for his dedication
to molecular medicine and improving others'
lives through higher education.